A5050302408- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Soft tissue tumor case studies
- Peripheral Nerve Disorders
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Oral and Maxillofacial Pathology
- Metabolism, Diabetes, and Cancer
- Cervical Cancer and HPV Research
- Meningioma and schwannoma management
- Cancer-related Molecular Pathways
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Genital Health and Disease
- Urologic and reproductive health conditions
- Lymphoma Diagnosis and Treatment
- Advancements in Semiconductor Devices and Circuit Design
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
Nanchang University
2024
First People's Hospital of Chongqing
2022-2023
Soochow University
2021
Second Affiliated Hospital of Soochow University
2021
Xiamen Medical College
2021
Lifetech Scientific (China)
2020
Geisinger Medical Center
2016-2017
Jiangxi Maternal and Child Health Hospital
2014
Guizhou Cancer Hospital
2010-2013
Cytokine release syndrome (CRS) remains to be a major adverse effect of chimeric antigen receptor T (CAR-T) cell therapy in B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. It was urgent explore novel strategy for managing severe CRS. We conducted clinical trial assess the safety efficacy CD19-targeting CAR-T-cells treatment relapsed chemotherapy-refractory B-ALL A 10-year-old boy with who never achieved minimal residual disease (MRD) negative status after 5 courses chemotherapy...
Aim: CD19 chimeric antigen receptor (CAR) T cells have been approved by the US FDA for treatment of relapsed and refractory (R/R) B-cell malignancies. Patients & methods: This study investigated safety efficacy autologous 4-1BB costimulatory domain-engineered CAR-T in R/R lymphoma. Results: After CAR-T-cell infusion, severe cytokine release syndrome occurred 28.6% (4/14) patients. The overall response rate was 77% with complete remission observed 6/14 patients at 3 months. A higher tumor...
Cisplatin, metformin, and quercetin are all reliable anticancer drugs. However, it is unclear how effective their different combination regimens on the growth of nasopharyngeal carcinoma cell line Sune-1 subcutaneous xenograft in nude mice. This study evaluated effects single-drug, two-drug, three-drug simultaneous or sequential combined application these drugs cells tumors The results showed that cisplatin, metformin had significant inhibitory proliferation xenografts mice (P < 0.01),...
Abstract: Despite the prominent effects of BCR-ABL tyrosine kinase inhibitors (TKI) therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) and thus low incidence blastic transformation, blast phase (BP)-CML remains a major therapeutic challenge TKI era. The "gatekeeper" mutation T315I BCR-ABL1 kinase, which often coupled poor prognosis, is quite common resistant to all TKIs except for ponatinib. occurrence BP-CML makes situation more complex. Anti-CD19 chimeric antigen...
Rhabdomyosarcoma (RMS) with TFCP2 rearrangement has been identified recently. This entity a distinctive clinicopathologic features: rapidly aggressive clinical course, preference for the craniofacial bones, spindle and epithelioid histomorphology, positive immunohistochemistry epithelial markers, ALK, myogenic markers. RMS is rare may be misdiagnosed as other cell tumors. Here, we report case of this arising in mandible, which was initially diagnosed ossifying fibroma primary tumor another...
1547 Background: Despite FDA approval of medications for breast cancer risk reduction and professional organizations’ (ASCO, USPSTF & NCCN) chemoprevention recommendations, use has not increased substantially. Barriers facilitators to primary care providers’ (PCP) incorporation could inform efforts increase uptake. Methods: We conducted an online survey PCPs’ regarding awareness chemoprevention, perceived barriers/solutions. All eligible PCPs at Geisinger Health System (family physicians,...
Renal cell carcinoma (RCC) is the most common renal tumor, with lung, bone, and liver being primary sites of metastasis. Thyroid metastasis, on other hand, relatively uncommon. Metastatic tumors in thyroid gland typically manifest as multiple or isolated nodules, which can be easily overlooked due to lack specific clinical imaging features. However, identification metastasis suggests presence systemic indicative a poor prognosis for patients. In this paper, we present two cases following...
Myofibroblastoma (MFB) of the breast is a rare benign neoplasm that exhibits several morphologic variants and presents diagnostic challenges for pathologists, especially in recognizing intra-operative frozen sections. In order to raise awareness this tumor avoid misdiagnosis, we describe case 38-year-old female patient diagnosed as epithelioid MFB. This painless was well-circumscribed, found left physically examined over period six months. Histologically, predominantly composed cells, which...
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis (LCH) that results in multiorgan involving the skin, bones, lungs, and kidneys. Female reproductive system manifestation of ECD was rare. Herein, we report case left ovary fallopian tube. A 69-year-old woman presented with abdominal pain for 20 days. Magnetic resonance imaging revealed solid cystic mass on pelvic cavity. Histological examination ovarian tube infiltration by abundant histiocytes, single small nuclei...
Objective To compare the therapeutic effects,side effects,and long-term survival between incremental chrono-chemotherapy with Dichlorodiammineplatinum (DDP) + 5-Fluorouracil (5-FU)/Calcium Folinate (CF) plus late course three-dimensional conformal radiotherapy (3D-CRT) and conventional chemotherapy in treatment of nasopharyngeal carcinoma (NPC).Methods Sixty NPC patients were divided randomly by envelope method into 2 equal groups:chrono-chemotherapy group treated radiotherapy,and routine...
Abstract Background: The culture of primary human peritoneal mesothelial cell (HPMC) provides us an in vitro tool to investigate fibrosis and ultrafiltration failure. aim the present study was establish method culturing HPMC explore clinical factors associated with success rate culture. Methods: HPMCs were aseptically harvested by centrifuge from dialysate effluent (PDE) patients end-stage renal disease (ESRD) who underwent dialysis (PD) catheterization for less than 2 weeks cultured . Cells...