A5102019277- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Healthcare and Venom Research
- Endometrial and Cervical Cancer Treatments
- Neurogenetic and Muscular Disorders Research
- Ureteral procedures and complications
- Amyotrophic Lateral Sclerosis Research
- Cancer-related Molecular Pathways
- Neurological Disease Mechanisms and Treatments
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Food Quality and Safety Studies
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Fungal Biology and Applications
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Lymphoma Diagnosis and Treatment
- Leaf Properties and Growth Measurement
- Cervical Cancer and HPV Research
- Acupuncture Treatment Research Studies
- MicroRNA in disease regulation
- Moyamoya disease diagnosis and treatment
Sun Yat-sen University
2008-2024
First Affiliated Hospital of Zhengzhou University
2009-2024
Zhejiang University of Science and Technology
2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Second Affiliated Hospital of Dalian Medical University
2024
Weatherford College
2024
Southern Medical University
2009-2024
Dalian Medical University
2024
Sun Yat-sen Memorial Hospital
2013-2023
Background Delayed neurocognitive recovery after surgery is associated with poor outcome. Most surgeries require general anesthesia, of which sevoflurane and propofol are the most commonly used inhalational intravenous anesthetics. The authors tested primary hypothesis that patients laparoscopic abdominal under propofol-based anesthesia have a lower incidence delayed than sevoflurane-based anesthesia. A second there were blood biomarkers for predicting to occur. Methods randomized,...
Cytospolides F–Q (6–17) and decytospolides A B (18 19), 14 unusual nonanolide derivatives, were isolated from Cytospora sp., an endophytic fungus Ilex canariensis. The structures elucidated by means of detailed spectroscopic analysis, chemical interconversion, X-ray single crystal diffraction. solution- solid-state conformers compared the combination experimental methods (X-ray, NMR) supported DFT calculations conformers. Absolute configurations assigned using modified Mosher's method TDDFT...
Ketogenic diet (KD) is popular in diabetic patients but its cardiac safety and efficiency on the heart are unknown. The aim of present study to determine effects underlined mechanisms KD function cardiomyopathy (DCM). We used db/db mice model DCM, different diets (regular or KD) were used. Cardiac interstitial fibrosis determined. T‐regulatory cell (Treg) number functions evaluated. ketone body (KB) fatty acid (FA) glucose metabolism, mitochondria‐associated endoplasmic reticulum membranes...
Abstract Background Gliomas are highly refractory intracranial cancers characterized by genetic and transcriptional heterogeneity. However, therapeutic options limited. In the last years, copper‐induced cell death is becoming a prospective treatment strategy for gliomas other solid tumors, but copper metabolism‐related genes associated with cancer development remain unclear. Methods We first collected gene expression data from The Cancer Genome Atlas (TCGA) to identify significantly...
The aim of this study was to examine the pathway and associations among acculturation (ie, language, social interaction lifestyle), psychological adjustment mental health internal migrant adolescents in China.Cross-sectional questionnaire study.Six private junior high schools located Tianhe Baiyun districts Guangzhou were chosen as sites.A total 1122 aged 11-17 years old completed study.Mental measured by using Social Anxiety Scale for Children (SASC) major depression disorder (MDD) a Brief...
Background and Purpose: The management of urolithiasis in patients with a solitary kidney is challenging for endourologists. This study was aimed at evaluating the safety efficacy retrograde intrarenal surgery (RIRS) treatment such renal stones. Patients Methods: Between January 2010 2014, we enrolled 45 who had underwent RIRS holmium:yttrium-aluminum-garnet lithotripsy We collected data pertaining to preoperative patient characteristics, stone dimensions, postoperative outcomes. Results:...
To evaluate the clinical efficacy, safety, and cost of retrograde intrarenal surgery (RIRS) percutaneous nephrolithotomy (PCNL) in treatment for large renal stones patients with a solitary kidney.In this study, 117 kidney who had undergone PCNL or RIRS larger than 2 cm between January 2010 December 2016 were retrospectively evaluated. The patients' demographic data, characteristics, perioperative outcomes collected through review their medical records. Forty-three treated compared to 43 by...
Inappropriately high expression of matrix metalloproteinase 9 (MMP9) in the late stage diabetic foot ulcers suppresses wound healing. The underlying mechanisms are not completely understood. Site-specific demethylation was reported to function regulation genes, causing persistent target genes. Therefore, this study designed determine whether site-specific DNA a key regulatory component MMP9 healing, and further verify crucial CpG site(s). Human keratinocyte cell line (HaCaT) cells were...
Diabetes mellitus is one of the most important risk factors for atherosclerosis. However, mechanisms underlying high-glucose-induced atherosclerosis remain unclear. This study was designed to observe effects high-glucose stimulation on permeability cultured human umbilical vein endothelial cells (HUVECs), and explore RhoA–Rho-associated protein kinase (ROCK) signal transduction pathway activation myosin light chain (MLC) phosphorylation. HUVECs were in conventional M199 medium produce cell...
Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high levels target genes. In present study, order to investigate association between DNA MMP9 promoter and EMT DN, human podocytes were cultured high‑glucose (HG) medium a rat model DN was established by intraperitoneal...
Aim: CD19 chimeric antigen receptor (CAR) T cells have been approved by the US FDA for treatment of relapsed and refractory (R/R) B-cell malignancies. Patients & methods: This study investigated safety efficacy autologous 4-1BB costimulatory domain-engineered CAR-T in R/R lymphoma. Results: After CAR-T-cell infusion, severe cytokine release syndrome occurred 28.6% (4/14) patients. The overall response rate was 77% with complete remission observed 6/14 patients at 3 months. A higher tumor...
The disease outbreak of Chinese perch poses a severe threat to aquaculture industry. To explore the relationship between microbial communities in farming water and those intestine, further reveal fish environmental microbes (internal external environments), 16S rRNA were sequenced. Although composition abundance bacterial phyla varied with month samples, Actinobacteria Proteobacteria always top 2 dominant phyla. Furthermore, most genera not significantly affected by factors seasonal changes,...
Purpose: This study aimed to compare the effectiveness and safety of single-stage bilateral unilateral retrograde intrarenal surgery (RIRS) for treatment patients with renal stones. Patients Methods: undergoing RIRS stones between January 2011 April 2014 were retrospectively reviewed matched at a 1:1 ratio by propensity score based on age, sex, body mass index, American Society Anesthesiologists classification, stone burden, location (involvement lower calix or not). Main outcome measures...
Among patients with Charcot-Marie-Tooth disease (CMT), the X-linked variant (CMTX) caused by gap junction protein beta 1 (GJB1) gene mutation is second most frequent type, accounting for approximately 90% of all CMTX. More than 400 mutations have been identified in GJB1 that encodes connexin 32 (CX32). CX32 thought to form junctions promote diffusion pathway between cells. interfere formation functional channel and impair maintenance peripheral myelin, novel are continually discovered.We...
Highlights•This trial evaluates the efficacy and safety of pyrotinib combined with chemotherapy•Patients luminal/HER2-low (IHC 2+/FISH-negative) early breast cancers are included•Pyrotinib chemotherapy has promising anti-tumor activity in (pre)clinical study•Pyrotinib a manageable toxicity profileSummaryThe prognosis patients luminal/human epidermal growth factor receptor 2 (HER2)-low cancer (EBC) needs to be improved. This preclinical study phase (ChiCTR2100047233) aims explore (a pan-HER...
Nowadays, it is widely known that decremental responses in low-frequency repetitive nerve stimulation (LF-RNS) are frequently observed patients with amyotrophic lateral sclerosis (ALS). The pathological mechanism of this phenomenon remains unknown. This study aimed to illuminate the features RNS Chinese ALS.Clinical and electrophysiological data 146 probable definite ALS who underwent were retrospectively enrolled analyzed. LF-RNS (3 Hz) was performed trapezius, deltoid, abductor digiti...
Carboplatin resistance in ovarian cancer (OV) is a major medical problem. Thus, there an urgent need to find novel therapeutic targets improve the prognosis of patients with carboplatin-resistant OV. Accumulating evidence indicates that gene COL1A1 (collagen type I alpha 1 chain) has important role chemoresistance and could be target. However, have been no reports about This study aimed establish detailed molecular mechanism predict potential drugs for its treatment. We found had pivotal...
The oncoprotein E6 of high-risk human papillomavirus (HPV) types promotes cell proliferation and contributes to carcinogenesis HPV-positive cervical cancer cells. In this study, we used small interfering RNA (siRNA) technology silence the <i>E6</i> gene in HPV-18-transformed line HeLa determined effects knockdown on by using microarray-based expression profiling coupled with functional classification bioinformatics methods. Silencing prepared siRNA cassettes against HPV-18 could...
The study was aimed to observe the morphology of intraepidermal nerve fibre (IENF) and explore relationships between density (IENFD) anatomic sites, age, genders races. Intraepidermal observed using immunohistochemistry. IENFD ages, races were analysed by quantitative analysis IENFD. Five patterns IENFs according morphological classification. A significant difference in different sites (P < 0.05). linear negative correlation age (r = − 0.2931, P 0.01). No found genders. at distal leg Chinese...