A5100725290- Circadian rhythm and melatonin
- Inflammatory mediators and NSAID effects
- Dietary Effects on Health
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cardiac Fibrosis and Remodeling
- Genetics, Aging, and Longevity in Model Organisms
- Cholesterol and Lipid Metabolism
- Climate Change and Health Impacts
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Sleep and Wakefulness Research
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Lung Cancer Treatments and Mutations
- Macrophage Migration Inhibitory Factor
Dalian Medical University
2016-2025
East China Normal University
2022-2025
Guizhou Provincial People's Hospital
2025
Fujian Medical University
2011-2024
Mengchao Hepatobiliary Hospital
2014-2024
Union Hospital
2020-2024
Shaanxi Provincial People's Hospital
2020-2024
Shanxi Medical University
2020-2024
Wuhu Fourth People Hospital
2024
Shanghai Jiao Tong University
2024
The absence of Bmal1, a core clock gene, results in loss circadian rhythms, an acceleration aging, and shortened life span mice. To address the importance rhythms aging process, we generated conditional Bmal1 knockout mice that lacked BMAL1 protein during adult found wild-type variations wheel-running activity, heart rate, blood pressure were abolished. Ocular abnormalities brain astrogliosis conserved irrespective timing deletion. However, span, fertility, body weight, glucose levels,...
The response to an innate immune challenge is conditioned by the time of day, but molecular basis for this remains unclear. In myeloid cells, there a temporal regulation induction lipopolysaccharide (LPS) proinflammatory microRNA miR-155 that correlates inversely with levels BMAL1. BMAL1 in lineage inhibits activation NF-κB and protects mice from LPS-induced sepsis. Bmal1 has two miR-155-binding sites its 3'-UTR, and, LPS, binds these target sites, leading suppression mRNA protein humans....
Abstract Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results cardio-metabolic, immunological neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors humans. Here we integrated data from remote sensors, physiological multi-omics analyses to assess the feasibility of detecting time dependent signals - chronobiome – despite “noise” attributable behavioral differences free-living...
GSK-1614235 and KGA-2727 are potent, selective inhibitors of the SGLT1 sodium-dependent glucose transporter. Nonclinical (KGA-2727) clinical (GSK-1614235) trials assessed translation inhibitor effects from rats to normal human physiology. In rats, (0.1 mg/kg) or vehicle was given before oral administration 3- O-methyl-α-d-glucopyranose (3- O-methylglucose, 3-OMG) containing 3-[ 3 H]OMG tracer. Tracer absorption distribution were plasma, urine, fecal samples. inhibition reduced urine 3-OMG...
Prostaglandin E2 (PGE2) plays an important role in vascular homeostasis. Its receptor, E-prostanoid receptor 4 (EP4) is essential for physiological remodeling of the ductus arteriosus (DA). However, EP4 pathological remains largely unknown. We found that chronic angiotensin II (AngII) infusion mice with smooth muscle cell (VSMC)-specific gene knockout (VSMC-EP4-/-) frequently developed aortic dissection (AD) severe elastic fiber degradation and VSMC dedifferentiation. AngII-infused...
Clinical use of prostaglandin synthase-inhibiting NSAIDs is associated with the development hypertension; however, cardiovascular effects antagonists for individual receptors remain uncharacterized. The present studies were aimed at elucidating role E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure. Oral administration EP1 antagonist SC51322 reduced pressure spontaneously hypertensive rats. To define whether this antihypertensive effect was caused by inhibition, an...
Background— Microsomal (m) prostaglandin (PG) E 2 synthase (S)-1 catalyzes the formation of PGE from PGH , a cyclooxygenase product that is derived arachidonic acid. Previous studies in mice suggest targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2–selective inhibition deletion vivo. Indeed, retards atherogenesis and angiotensin II–induced aortic aneurysm formation. The role response vascular injury unknown. Methods Results— Mice were subjected...
Although the molecular components of circadian rhythms oscillate in discrete cellular vasculature and many aspects vascular function display diurnal variation, connections between clock inflammatory cardiovascular diseases remain to be elucidated. Previously we have shown that pre- versus postnatal deletion Bmal1 (brain muscle aryl hydrocarbon receptor nuclear translocator-like 1), nonredundant core gene has contrasting effects on atherogenesis. Here investigated effect myeloid cell...
SUV39H1 is a histone H3K9-specific methyltransferase important for heterochromatin formation, regulation of gene expression, and induction senescence in premalignant cells. forms complex with SirT1, its activity stimulated by SirT1 binding. Here we present evidence that the product DBC1 (deleted breast cancer 1) disrupts SUV39H1-SirT1 complex. Furthermore, binds to catalytic domain inhibits ability methylate H3 vitro vivo. Knockdown endogenous increased level cellular H3K9 methylation. As...
Multiple types of responses, such as displacements, ground water level, pore pressures, contents, etc., are usually measured in comprehensive monitoring programmes for rainfall-induced landslide prevention. In this study, a probabilistic calibration method coupled hydro-mechanical modelling slope stability is presented with integration multiple measurements. A numerical example soil under rainfall infiltration illustrated to compare the effects single and responses on parameter estimation...
The present studies aimed at elucidating the role of prostaglandin E(2) receptor subtype 3 (E-prostanoid [EP] 3) in regulating blood pressure.Mice bearing a genetic disruption EP3 gene (EP(3)(-/-)) exhibited reduced baseline mean arterial pressure monitored by both tail-cuff and carotid catheterization. pressor responses induced agonists M&B28767 sulprostone were markedly attenuated EP3(-/-) mice, whereas reduction was comparable genotypes. Vasopressor effect acute or chronic infusion...