A5083547752- Ovarian cancer diagnosis and treatment
- Dermatology and Skin Diseases
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Molecular Biology Techniques and Applications
- Diabetic Foot Ulcer Assessment and Management
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Tryptophan and brain disorders
- Online and Blended Learning
- Web and Library Services
- Gut microbiota and health
- Immune Cell Function and Interaction
- Breast Cancer Treatment Studies
- Pressure Ulcer Prevention and Management
- Ichthyology and Marine Biology
- Clinical practice guidelines implementation
- Mobile Learning in Education
- Genetic Mapping and Diversity in Plants and Animals
- Surgical site infection prevention
- Reproductive System and Pregnancy
- Evolution and Paleontology Studies
- Breast Lesions and Carcinomas
- Advancements in Transdermal Drug Delivery
University of Pennsylvania
2017-2025
Children's Hospital of Philadelphia
2024-2025
Translational Therapeutics (United States)
2017-2024
University of Iowa
2024
Oberlin College
2022
University of Glasgow
2018
University College London
2017
University of London
2017
Leeds Beckett University
2016
Medical University of South Carolina
2011-2013
Abstract Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results cardio-metabolic, immunological neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors humans. Here we integrated data from remote sensors, physiological multi-omics analyses to assess the feasibility of detecting time dependent signals - chronobiome – despite “noise” attributable behavioral differences free-living...
Strain-level variation in Staphylococcus aureus is a factor that contributes to disease burden and clinical outcomes skin disorders chronic wounds. However, the microbial mechanisms drive these variable host responses are poorly understood. To identify underlying strain-specific outcomes, we perform high-throughput phenotyping screens on S. isolates cultured from diabetic foot ulcers. Isolates non-healing wounds produce more staphyloxanthin, cell membrane pigment. In murine wounds,...
Chronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, infection. We previously showed that aspects the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial species recovered remain uninvestigated respect wound healing. Here, we focused on
The purpose of this article is to correlate various ultrasound features breast cancer with tumor grade, and estrogen, progesterone, ERRB2 (formerly HER2) receptor status as well assess the predictive value these features.The cancers found by using between January 2010 June 2011 were reviewed for size, margins, posterior acoustic features. margins classified into spiculated, angular, indistinct, lobulated or microlobulated, circumscribed. shadowing, enhancement, mixed pattern, no change....
The availability of genomic and proteomic data from across the tree life has made it possible to infer features genome proteome last universal common ancestor (LUCA). A number studies have done so, all using a unique set methods bioinformatics databases. Here, we compare predictions eight such measure both their agreement with one another consensus among them. We find that some LUCA show strong others, but no individual study shares high or even moderate degree similarity any other study....
Metaplastic carcinoma (MPC), an uncommon but often aggressive breast cancer, can be challenging to differentiate from other types of cancer and even benign lesions based on the imaging appearance. It has a variable pathology classification system. These tumors are generally rapidly growing palpable masses. MPCs present with features similar invasive ductal probably lesions. The purpose this article is review MPC including subtypes, features, correlations. By understanding clinical picture,...
Abstract Background The global spread of methicillin-resistant Staphylococcus aureus (MRSA) is associated with distinct clones predominating in specific geographical regions. Available evidence suggests that the Chilean-Cordobes clone (ChC), an ST5-SCCmecI lineage, has predominated Chilean hospitals ever since its first description 1998. However, we recently reported a gradual decrease this lineage over time, frequencies dropping from 94% (2000) to 52% (2016). To understand clonal...
Objective: Opioid tolerance is a criterion for opioid use disorder, which currently an epidemic in the US. Individuals with open wounds are frequently administered opioids; however, phenomenon of has not been examined context wounds. The purpose this exploratory study was to compare patient/wound factors, wound microbiome and inflammatory mediators between individuals who were opioid-tolerant versus those opioid-tolerant. Method: Patients acute enrolled cross-sectional study. All data...
To determine if ultrasound and/or mammography is helpful in detecting breast cancers patients presenting with focal pain. Patients who presented between February 2008 and April 2011 pain without a lump were included the study. The mammographic US findings retrospectively reviewed. BIRADS 0, 4, 5 considered positive on mammogram while 4 US. efficacy of mammogram-alone, ultrasound-alone, combination to detect cancer was evaluated. performance for any mass lesions that present subsequent also A...
ABSTRACT The microbiota mediate multiple aspects of skin barrier function, including colonization resistance to pathogens such as Staphylococcus aureus . endogenous limits S. via competition and direct inhibition. Novel mechanisms are promising therapeutic targets for drug-resistant infections, those caused by methicillin-resistant (MRSA). Here, we developed characterized a swine model topical microbiome perturbation MRSA colonization. As in other systems, antimicrobial treatment had little...
Abstract Background Decision-making when considering major lower limb amputation is complex and requires individualized outcome estimation. It unknown how accurate healthcare professionals or relevant prediction tools are at predicting outcomes 1-year after amputation. Methods An international, multicentre prospective observational study evaluating professional accuracy in 1 year evaluation of identified a systematic search the literature was undertaken. Observed were compared with:...
Recommendations for enhancing scientific literacy, inclusivity, and the ecosystem innovation call transitioning from teacher-centered to learner-centered science classrooms, particularly at introductory undergraduate level. Yet little is documented about challenges that undergraduates perceive in such classrooms students' ways of navigating them. Via mixed methods, we studied undergraduates' lived experience one form teaching, hybrid project-/problem-based learning (PBL), organismal biology...
The purpose of this study was to determine the efficacy 3D and 4D ultrasound in correlation with hepatoiminodiacetic acid (HIDA) scanning for calculating gallbladder ejection fraction (EF).A prospective conducted 40 adult patients suspected dyskinesia. Cholecystokinin-provoked (99m)Tc-HIDA scintigraphy performed, concurrent images were obtained before cholecystokinin infusion 20, 30, minutes after infusion. EF values calculated from HIDA scan compared.The (mean ± standard error mean) 20...
Abstract Background The accuracy with which healthcare professionals (HCPs) and risk prediction tools predict outcomes after major lower limb amputation (MLLA) is uncertain. aim of this study was to evaluate the predicting short-term (30 days MLLA) mortality, morbidity, revisional surgery. Methods PERCEIVE (PrEdiction Risk Communication outcomE following amputation: a collaboratIVE) launched on 1 October 2020. It an international multicentre study, including adults undergoing MLLA for...
Abstract Background: High-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC in Black individuals and considered whether differences by self-identified race may contribute to poorer survival among versus White individuals. Methods: included newly generated RNA sequencing data from array-based genotyping four existing studies of Japanese used K-means clustering, a method no predefined number clusters or dataset-specific...
Wound dressing changes are essential procedures for wound management. However, ~50% of patients experience severe pain during these despite the availability analgesic medications, indicating a need novel therapeutics that address underlying causes pain. Along with other clinical factors, pathogens and inflammatory immune responses have previously been implicated in To test whether factors could contribute to changes, we conducted an exploratory, cross-sectional analysis patient-reported...
NK cells can co-express inhibitory and activating killer Ig-like receptors (KIR) recognizing the same HLA class I ligand. We present evidence from experiments with expressing both (KIR2DS2) (KIR2DL2 KIR2DL3) that KIR function without apparent interference KIR. These studies used CD158b mAb is equally reactive KIR2DS2, KIR2DL2 KIR2DL3. First, we show using plastic-immobilized KIR2DS2 stimulated, resulting in cell division degranulation. Second, soluble FcRII + P815 high concentrations of...
Controversy exists as to whether a high or low tie ligation of the inferior mesenteric artery (IMA) is preferred technique in surgeries left colon and rectum. This study aims contribute discussion which more beneficial by investigating neurovasculature at each site.Ten embalmed cadaveric donors underwent division level tie. The was subsequently ligated root render section tissue for histological analysis proximal (high tie), mid distal (low tie) segments.Ganglia observed end seven specimens...
SUMMARY The epidermis forms a barrier that defends the body from desiccation and entry of harmful substances, while sensing integrating environmental signals. tightly orchestrated cellular changes required for proper formation maintenance this epidermal occur in context skin microbiome. Using germ free mice, we demonstrate microbiota is necessary differentiation repair barrier. These effects were mediated by aryl hydrocarbon receptor (AHR) keratinocytes, xenobiotic also implicated...
Chronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, infection. We previously showed that aspects the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial species recovered remain uninvestigated respect wound healing. Here we focused on
We investigate new interfaces that allow users to specify topics of interest in streams weblog stories by providing relevance feedback a search algorithm. Noting often contain photographs taken the blogger during course narrated events, we whether these can serve as proxy for whole post when are making judgments post's relevance. developed story annotation interface collecting with three variations: presented either full it appears weblog, an embedded photograph, or only title post. describe...