A5036964722- Mosquito-borne diseases and control
- Gut microbiota and health
- Dermatology and Skin Diseases
- Malaria Research and Control
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Salmonella and Campylobacter epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
- Clostridium difficile and Clostridium perfringens research
- Toxoplasma gondii Research Studies
Duke University
2022-2024
Duke University Hospital
2023
Duke Medical Center
2023
University of Pennsylvania
2022-2023
Gettysburg College
2018
Salmonella enterica is the leading bacterial cause of foodborne illness in United States and represented by over 2,600 distinct serovars. Some these serovars are pathogenic humans, while others not. Current surveillance for this pathogen limited detection only most abundant serovars, due to culture-based approaches that used. Thus, present a minority remain undetected. By exploiting serovar-specific differences CRISPR arrays spp., we have developed high-throughput sequencing tool be able...
ABSTRACT The microbiota mediate multiple aspects of skin barrier function, including colonization resistance to pathogens such as Staphylococcus aureus . endogenous limits S. via competition and direct inhibition. Novel mechanisms are promising therapeutic targets for drug-resistant infections, those caused by methicillin-resistant (MRSA). Here, we developed characterized a swine model topical microbiome perturbation MRSA colonization. As in other systems, antimicrobial treatment had little...
Little is known about how microbiota regulate innate-like γδ T cells or these restrict their effector functions within mucosal barriers, where provide chronic stimulation. Here, we show that microbiota-mediated regulation of γδ17 binary, instruct in situ interleukin-17 (IL-17) production and concomitant expression the inhibitory receptor programmed cell death protein 1 (PD-1). Microbiota-driven PD-1 IL-17 preferential adoption a PD-1high phenotype are conserved for across multiple barriers....
ABSTRACT The apicomplexans Toxoplasma gondii and Plasmodium are intracellular parasites that reside within a host-derived compartment termed the parasitophorous vacuole (PV). During infection, must acquire critical host resources transport them across their PV for development. However, mechanism by which trafficked to remains uncertain. Here, we investigated ADP ribosylation factors (Arfs), class of proteins involved in vesicular trafficking may be exploited T. berghei nutrient acquisition....
ABSTRACT The microbiota mediates multiple aspects of skin barrier function, including colonization resistance to pathogens such as Staphylococcus aureus. endogenous limits S. aureus via competition and direct inhibition. Novel mechanisms are promising therapeutic targets for drug-resistant infections, those caused by methicillin-resistant (MRSA). Here, we developed characterized a swine model topical microbiome perturbation MRSA colonization. As in other systems, antimicrobial treatment had...