A5046065699- Diabetic Foot Ulcer Assessment and Management
- Anesthesia and Pain Management
- Ear Surgery and Otitis Media
- Peripheral Artery Disease Management
- Pain Management and Treatment
- Total Knee Arthroplasty Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Sepsis Diagnosis and Treatment
- Pediatric Pain Management Techniques
- Respiratory and Cough-Related Research
- Clinical practice guidelines implementation
- Nerve Injury and Rehabilitation
- Computational Drug Discovery Methods
- Prosthetics and Rehabilitation Robotics
- Dermatologic Treatments and Research
- Neonatal and Maternal Infections
- Radio, Podcasts, and Digital Media
- Interprofessional Education and Collaboration
- Antibiotic Use and Resistance
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Innovations in Educational Methods
- Focus Groups and Qualitative Methods
- Infant Nutrition and Health
- Clinical Reasoning and Diagnostic Skills
Cardiff University
2015-2025
DePaul University
2007-2009
Ludwig Cancer Research
2005
SummaryBackgroundProcalcitonin is a rapid response biomarker specific for bacterial infection, which not routinely used in the UK National Health Service. We aimed to assess whether using procalcitonin-guided algorithm would safely reduce duration of antibiotic therapy compared with usual care, C-reactive protein commonly biomarker.MethodsThe BATCH trial was pragmatic, multicentre, open-label, parallel, two-arm, individually randomised, controlled conducted 15 hospitals England and Wales....
Despite repeated vaccinations against SARS-CoV-2 virus, patients who are immunocompromised remain at very high risk of catching virus and becoming unwell. AZD7442 (Evusheld) is a long-acting monoclonal antibody treatment that has been shown in clinical trials to prevent infection for up year after single dose. Vaccines require healthy immune system generate protective immunity. may individuals not have responded virus. Unlike vaccinations, reaches effective levels within the body few hours...
BackgroundChildren with persistent hearing loss due to otitis media effusion are commonly managed by surgical intervention. A safe, cheap, and effective medical treatment would enhance options. Underpowered, poor-quality trials have found short-term benefit from oral steroids. We aimed investigate whether a short course of steroids achieve acceptable in children loss.MethodsIn this individually randomised, parallel, double-blinded, placebo-controlled trial we recruited aged 2–8 years...
Abstract Background Decision-making when considering major lower limb amputation is complex and requires individualized outcome estimation. It unknown how accurate healthcare professionals or relevant prediction tools are at predicting outcomes 1-year after amputation. Methods An international, multicentre prospective observational study evaluating professional accuracy in 1 year evaluation of identified a systematic search the literature was undertaken. Observed were compared with:...
Procalcitonin (PCT) is a biomarker more specific for bacterial infection and responds quicker than other commonly used biomarkers such as C reactive protein, but not routinely in the National Health Service (NHS). Studies mainly adults show that using PCT to guide clinicians may reduce antibiotic use, hospital stay, with no associated adverse effects increased rates of re-admission, incomplete treatment infections, relapse or death. A review conducted Institute Care Excellence recommends...
Otitis media with effusion (OME) is an accumulation of fluid in the middle ear affecting about 80 % children by age 4 years. While OME usually resolves spontaneously, it can affect speech, behaviour and development. Children persistent hearing loss associated are offered aids or insertion ventilation tubes through tympanic membrane. Oral steroids may be a safe effective treatment for OME, which could delivered primary care. Treatment oral has potential to benefit large numbers reduce burden...
Abstract Background The accuracy with which healthcare professionals (HCPs) and risk prediction tools predict outcomes after major lower limb amputation (MLLA) is uncertain. aim of this study was to evaluate the predicting short-term (30 days MLLA) mortality, morbidity, revisional surgery. Methods PERCEIVE (PrEdiction Risk Communication outcomE following amputation: a collaboratIVE) launched on 1 October 2020. It an international multicentre study, including adults undergoing MLLA for...
Purpose Rehabilitation experiences of lower limb amputees with poorer physical health have not been fully explored. This study aimed to qualitatively explore rehabilitation amongst patients who had recently undergone amputation due complications vascular disease.
Objectives To determine the feasibility of undertaking a randomised controlled effectiveness trial evaluating use perineural catheter (PNC) after major lower limb amputation with postoperative pain as primary outcome. Design Randomised trial. Setting Two vascular Centres in South Wales, UK. Participants 50 patients scheduled for (below or above knee) complications peripheral disease. Interventions The treatment arm received PNC placed adjacent to sciatic tibial nerve at time surgery,...
Pain after major lower limb amputation for peripheral arterial disease (PAD) is a significant problem. A perineural catheter (PNC) can be placed adjacent to the nerve at time of with continuous local anaesthetic infusion given postoperatively try and reduce pain. Although low-quality observational data suggest that PNC usage reduces postoperative opioid requirements, there are limited regarding its effect on The aim PLACEMENT explore feasibility running an effectiveness trial assess impact...
Objectives To explore patient experiences, understanding and perceptions of analgesia following major lower limb amputation. Design Qualitative interview study, conducted as part a randomised controlled feasibility trial. Setting Participants were recruited from two general hospitals in South Wales. Interview participants patients enrolled PLACEMENT (Perineural Local Anaesthetic Catheter aftEr Major lowEr amputatioN Trial): trial comparing the use perineural catheter (PNC) versus standard...
Children with hearing loss associated otitis media effusion (OME) are commonly managed through surgical intervention, aids or watchful waiting. A safe, inexpensive, effective medical treatment would enhance options. Small, poorly conducted trials have found a short-term benefit from oral steroids.To determine the clinical effectiveness and cost-effectiveness of 7-day course steroids in improving at 5 weeks children persistent OME symptoms current bilateral demonstrated by...
Accurate prediction of outcomes following surgery with high morbidity and mortality rates is essential for informed shared decision-making between patients clinicians. It unknown how accurately healthcare professionals predict major lower-limb amputation (MLLA). Several MLLA outcome-prediction tools have been developed. These could be valuable in clinical practice, but most require validation independent cohorts before routine use can recommended. The primary aim this study to evaluate the...
The majority of pre-registration nurse students undertake placements in secondary care, ill-preparing them for an NHS which primary care is taking increasingly important role. To overcome this discrepancy a pathway was developed by London Sothbank University to provide those interested entering nursing gain experience working care. Aim: make formal evaluation students′ perceptions the PCP programme. Method: All were invited evaluate course and 20 responded. Focus group one-to-one discussions...
Introduction Deciding whether to proceed with a major lower limb amputation is life-changing and complex, it crucial that the right decision made at time. However, medical specialists are known poorly predict risk when assessing patients for surgery, there little guidance research regarding decisions about amputation. The process of shared decision-making between doctors during surgical consultations also understood. Therefore, aim this study analyse in depth communication, consent,...
OSTRICH is a randomised controlled trial for otitis media with effusion (OME) in children, to determine the clinical and cost effectiveness of short course oral steroids. The aim describe evaluate factors that have contributed lower than expected recruitment rates.
This discussion paper explores the current drivers of change in Higher Education institutions England. It presents models students and asks you to consider your own institution student engagement within it. will then offer detail a research project that Newman University have begun.
We all need fast, accurate and detailed information when embarking on the process of arranging for a loved one to enter care home. The utility comparison websites in this endeavour is highlighted.