A5101680917- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Coastal and Marine Dynamics
- Coastal wetland ecosystem dynamics
- Marine and coastal ecosystems
- Nutrition and Health in Aging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Oceanographic and Atmospheric Processes
- Delphi Technique in Research
- Geological formations and processes
- Cardiovascular and exercise physiology
- Geology and Paleoclimatology Research
- Osteoarthritis Treatment and Mechanisms
- Frailty in Older Adults
- Obesity and Health Practices
- Body Composition Measurement Techniques
- Cystic Fibrosis Research Advances
- Marine and fisheries research
- Hydrology and Sediment Transport Processes
- Pediatric health and respiratory diseases
- Occupational and environmental lung diseases
- Emergency and Acute Care Studies
- Cardiac Health and Mental Health
- Dysphagia Assessment and Management
- Eating Disorders and Behaviors
The University of Melbourne
2020-2025
Royal Brompton & Harefield NHS Foundation Trust
2012-2024
Imperial College London
2013-2024
University of Illinois Urbana-Champaign
2021-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
The Ohio State University
2021-2024
Pennine Care NHS Foundation Trust
2024
Berkshire Healthcare NHS Foundation Trust
2024
Harefield Hospital
2013-2022
Lung Institute
2020
PURPOSE To determine the cardioprotective effect of dexrazoxane (DZR) used in a doxorubicin-based combination therapy advanced breast cancer. PATIENTS AND METHODS Between November 1988 and January 1991, 534 patients with cancer were randomized to two multicenter, double-blind studies (088001 088006). Patients received fluorouracil, doxorubicin, cyclophosphamide (FAC) either DZR (DZR-to-doxorubicin ratio, 10:1) or placebo (PLA) every 3 weeks monitored serial multiplegated acquisition (MUGA)...
BackgroundThe COPD Assessment Test (CAT) is responsive to change in patients with chronic obstructive pulmonary disease (COPD). However, the minimum clinically important difference (MCID) has not been established. We aimed identify MCID for CAT using anchor-based and distribution-based methods.MethodsWe did three studies at two centres London (UK) between April 1, 2010, Dec 31, 2012. Study 1 assessed score before after 8 weeks of outpatient rehabilitation who were able walk 5 m, had no...
<h3>Background</h3> Age-related loss of muscle, sarcopenia, is recognised as a clinical syndrome with multiple contributing factors. International European Working Group on Sarcopenia in Older People (EWGSOP) criteria require generalised muscle mass and reduced function to diagnose sarcopenia. Both are common COPD but usually studied isolation the lower limbs. <h3>Objectives</h3> To determine prevalence sarcopenia COPD, its impact health status, relationship quadriceps strength response...
<h3>Background</h3> Moving from sitting to standing is a common activity of daily living. The five-repetition sit-to-stand test (5STS) lower limb function that measures the fastest time taken stand five times chair with arms folded. 5STS has been validated in healthy community-dwelling adults, but data chronic obstructive pulmonary disease (COPD) populations are lacking. <h3>Aims</h3> To determine reliability, validity and responsiveness patients COPD. <h3>Methods</h3> Test-retest...
Frailty is an important clinical syndrome that consistently associated with adverse outcomes in older people. The relevance of frailty to chronic respiratory disease and its management unknown.To determine the prevalence among patients stable COPD examine whether affects completion pulmonary rehabilitation.816 outpatients (mean (SD) age 70 (10) years, FEV1% predicted 48.9 (21.0)) were recruited between November 2011 January 2015. was assessed using Fried criteria (weight loss, exhaustion,...
<h3>Abstract</h3> <h3>Rationale</h3> Several randomised controlled trials support the provision of early pulmonary rehabilitation (PR) following hospitalisation for acute exacerbation chronic obstructive disease (AECOPD). However, there is little real-world data regarding uptake, adherence and completion rates. <h3>Methods</h3> An audit was conducted to prospectively document referral, rates post-hospitalisation outpatient PR in Northwest London over a 12-month period. <h3>Results</h3> Out...
In community-dwelling older adults, usual gait speed over 4 m (4MGS) consistently predicts greater risk of adverse health outcomes. The aims the present study were to assess reliability 4MGS and relationship with established outcome measures in chronic obstructive pulmonary disease (COPD). Test-retest interobserver measured 80 58 COPD patients, respectively. 586 4MGS, as well forced expiratory volume 1 s (FEV1), incremental shuttle walk (ISW), Medical Research Council (MRC) dyspnoea scale St...
<h3>Background</h3> The Clinical COPD Questionnaire (CCQ) is a simple 10-item, health-related quality of life questionnaire (HRQoL) with good psychometric properties. However, little data exists regarding the responsiveness CCQ to pulmonary rehabilitation (PR) or minimal clinically important difference (MCID). study aims were assess PR, compare other HRQoL questionnaires and provide estimates for MCID. <h3>Methods</h3> CCQ, St George9s Respiratory (SGRQ), Chronic (CRQ) Assessment Test (CAT)...
Usual gait speed is a consistent predictor of adverse outcomes in community-dwelling elderly people. The reliability and validity the 4-m (4MGS) has recently been demonstrated patients with chronic obstructive pulmonary disease (COPD). aims this study were to assess responsiveness 4MGS estimate minimal clinically important difference (MCID). In 301 COPD patients, incremental shuttle walk (ISW) measured before after rehabilitation. ISW also at baseline 1 year later separate cohort 162...
<h3>Background</h3> Hospitalisation for acute exacerbations of COPD is associated with high risk readmission. However, no tool has been validated to stratify patients at discharge <h3>Aim</h3> To evaluate the ability 4 m gait speed (4MGS), a surrogate marker frailty, predict future readmission in hospitalised an exacerbation (AECOPD). <h3>Methods</h3> 213 AECOPD were recruited prospectively. 4MGS was measured on day discharge. Logistic regression models used assess association between and 90...
Rationale: Increasing physical activity is a key therapeutic aim in chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation (PR) improves exercise capacity, but there conflicting evidence regarding its ability to improve levels.Objectives: To determine whether using pedometers as an adjunct PR can enhance time spent at least moderate-intensity (time expending ≥3 metabolic equivalents [METs]) by people with COPD.Methods: In this single-blind randomized controlled trial,...
Abstract Background Cachexia is an important extra‐pulmonary manifestation of chronic obstructive pulmonary disease (COPD) presenting as unintentional weight loss and altered body composition. Previous studies have focused on the relative importance composition compared with mass rather than dynamic static measures. We aimed to determine prevalence cachexia pre‐cachexia phenotypes in COPD examine associations between its component features all‐cause mortality. Methods enrolled 1755...
The aims of the study were to evaluate responsiveness Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale HADS-Depression (HADS-D) pulmonary rehabilitation (PR) in patients with bronchiectasis compared a matched group chronic obstructive disease (COPD) provide estimates minimal clinically important difference (MCID) HADS-A HADS-D bronchiectasis. Patients at least mild anxiety or depression (HADS-A ≥ 8 or/and 8), as well propensity score-matched control COPD, underwent an 8-week...
Home-based exercise has been proposed as an equivalent treatment strategy to supervised outpatient pulmonary rehabilitation (PR), but it is not known whether its implementation into clinical practice produces similar benefits those observed in trials. We compared the real-world responses of 154 patients with COPD undergoing home-based a matched group attending PR. smaller improvements capacity PR, quality life. propose that PR remains standard care, less effective alternative for unable attend
To compare the perceptions of patients about why they did, or did not, respond to a physical therapist-supported exercise and activity program.This was qualitative study within randomized controlled trial. Twenty-six participants (of 40 invited) with knee osteoarthritis sampled according response (n = 12 responders, 14 nonresponders based on changes in both pain function at 3 9 months after baseline) an intervention. Semistructured individual interviews were conducted. Inductive thematic...
International guidelines recommend pulmonary rehabilitation for patients with bronchiectasis, supported by small trials and data extrapolated from chronic obstructive disease (COPD). However, it is unknown whether real-life on completion rates response to are similar between bronchiectasis COPD. Using propensity score matching, 213 consecutive referred a supervised programme were matched 1:1 control group of Completion rates, change in incremental shuttle walk (ISW) distance Chronic...
Health status is increasingly used in clinical practice to quantify symptom burden and as a trial end-point patients with interstitial lung disease (ILD). The King's Brief Interstitial Lung Disease (KBILD) questionnaire brief, validated 15-item, disease-specific, health-related quality of life that trials, but little data exist regarding the minimum clinically important difference (MCID). Using pulmonary rehabilitation model, we aimed determine responsiveness KBILD provide estimates MCID....
The delivery of physiotherapy via telehealth could provide more equitable access to services for patients. Videoconference-based has been shown be an effective and acceptable mode service exercise-based interventions chronic knee pain; however, specific training in is required physiotherapists effectively consistently deliver care using telehealth. development evaluation programs upskill health professionals the management osteoarthritis (OA) also identified as important priority improve OA...
Purpose Many medical schools require scholarly research projects. However, outcomes data from these initiatives are scarce. The authors studied the impact of Scholarly Research Project (SRP), a four-year longitudinal requirement for all students at University Pittsburgh School Medicine (UPSOM), on productivity and residency match. Method conducted study non-dual-degree UPSOM graduates in 2006 (n = 121, non-SRP participants) versus 2008 118), 2010 106), 2012 132), SRP participants. used...
Rationale: Pulmonary rehabilitation (PR) after hospitalizations for exacerbations of chronic obstructive pulmonary disease (COPD) improves exercise capacity and health-related quality life reduces readmissions. However, posthospitalization PR uptake is low. To date, no trials interventions to increase have been conducted.Objectives: study the effect a codesigned education video as an adjunct usual care on uptake.Methods: The present was assessor- statistician-blinded randomized controlled...