A5036793590- Bone fractures and treatments
- Mental Health and Patient Involvement
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Primary Care and Health Outcomes
- Radiation Therapy and Dosimetry
- Receptor Mechanisms and Signaling
- Health Policy Implementation Science
- Hip and Femur Fractures
- Diversity and Career in Medicine
- Asthma and respiratory diseases
- Mental Health Treatment and Access
- Boron Compounds in Chemistry
- Chronic Disease Management Strategies
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Nuclear Physics and Applications
- Cardiac electrophysiology and arrhythmias
- Respiratory and Cough-Related Research
- Radiation Detection and Scintillator Technologies
- Child and Adolescent Health
- Hemoglobinopathies and Related Disorders
- Clinical practice guidelines implementation
Bournemouth University
2025
Tibor Rubin VA Medical Center
2025
University of California, Irvine
2004-2024
Queen Elizabeth Hospital Birmingham
2004-2024
University of Birmingham
2014-2024
Royal North Shore Hospital
2024
University Hospitals Birmingham NHS Foundation Trust
2018-2024
Imperial College London
2012-2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2006-2023
North West London Pathology
2023
We have recently delineated three naturally occurring polymorphisms of the human beta 2-adrenergic receptor caused by missense mutations encoding for amino acids 16 and 27 extracellular N-terminus receptor. studied functional consequences these site-directed mutagenesis recombinant expression receptors in Chinese hamster fibroblasts. The consist substitutions Gly Arg at acid (Arg16-->Gly), Glu Gln (Gln27-->Glu), a combination both substitutions. All mutated displayed normal agonist binding...
The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates actions of catecholamines sympathetic nervous system. A polymorphism intracellular cytoplasmic tail near seventh transmembrane-spanning segment human beta1AR has been identified cohort normal individuals. At amino acid position 389, Gly or Arg can be found (allele frequencies 0.26 0. 74, respectively), former previously considered as wild-type beta1AR. Using...
External skeletal fixators (ESF) have a reputation for causing problems. Effective solutions exist some of these Delayed union can be avoided by accurate reduction, early bone grafting, and removal the ESF. Nerve vessel injury special attention to anatomy lateral arm forearm, upper medial thigh, junction third fourth quarters leg. Pin tract infections continue haunt ESF systems but are minimized necrosis tissue at pin-skin pin-bone interfaces. Undue soft or motion reduced bulky pin wraps...
Seventeen patients with segmental skeletal defects were managed the Ilizarov intercalary bone transport method, whereby an osseous defect is eliminated by elongating one fragment. On average, regenerate new length measured 5.14 cm, corresponding to creation of tissue equaling 13.7% bone's original (range, 4.2%-35%). The average time in fixation was 9.6 months, including 4.8 months fragment throughout limb. Numerous complications encountered, most commonly wire-site sepsis and fixator...
To evaluate two different methods of managing segmental skeletal defects, 15 patients treated with the open bone graft (Papineau) technique were compared 17 who had intercalary transport (Ilizarov) management. The treatment time was identical for both groups: 1.9 months in fixation each centimeter defect reconstructed. Both techniques shared several fixator-associated problems such as implant site sepsis and patient discomfort. Each method treatment, however, its own unique problems. For...
Many patients with acute asthma do not respond adequately to currently accepted therapy, including oxygen, beta-agonists, and corticosteroids. Leukotriene receptor antagonists such as montelukast have demonstrated efficacy in chronic asthma, but their is unknown. In this randomized, double-blind, parallel-group pilot study, adults moderate severe received standard therapy plus either intravenous (7 or 14 mg) matching placebo. A total of 201 were 194 had complete data available for analysis....
<h3>Abstract</h3> <h3>Rationale</h3> Several randomised controlled trials support the provision of early pulmonary rehabilitation (PR) following hospitalisation for acute exacerbation chronic obstructive disease (AECOPD). However, there is little real-world data regarding uptake, adherence and completion rates. <h3>Methods</h3> An audit was conducted to prospectively document referral, rates post-hospitalisation outpatient PR in Northwest London over a 12-month period. <h3>Results</h3> Out...
Abstract Mutations of the human B-RAF gene are detected in ∼8% cancer samples, primarily cutaneous melanomas (70%). The most common mutation (90%) is a valine-to-glutamic acid at residue 600 (V600E; formerly V599E according to previous nomenclature). Using Cre/Lox approach, we have generated conditional knock-in allele V600EB-raf mice. We show that widespread expression V600EB-Raf cannot be tolerated embryonic development, with embryos dying ∼7.5 dpc. Directed mutant somatic tissues using...
Kiwifruit vines rely on bees for pollen transfer between spatially separated male and female individuals require synchronized flowering to ensure pollination. Volatile terpene compounds, which are important cues insect pollinator attraction, were studied by dynamic headspace sampling in the major green-fleshed kiwifruit (Actinidia deliciosa) cultivar 'Hayward' its 'Chieftain'. Terpene volatile levels showed a profile dominated sesquiterpenes alpha-farnesene germacrene D. These two compounds...
An inherent therapeutic limitation of many G protein-coupled receptor agonists is a short duration action due to rapid dissociation from receptors. Salmeterol modified beta-adrenergic (betaAR) agonist that has long at the beta2AR (but not beta1AR) both in vitro and vivo persistent despite extensive washout agonist. It been proposed salmeterol binds only active site (localized transmembrane spanning domains (TMDs) 3 5) but also another (termed "exosite") anchors it provides for repetitive...
Abstract Background Prior optical coherence tomography (OCT) studies of schizophrenia have identified thinning retinal layers. However, findings varied across reports, and most had serious methodological limitations. To address unresolved issues, we determined whether: (1) in occurs independently comorbid medical conditions that affect the retina; (2) is independent antipsychotic medication dose; (3) optic nerve parameters are abnormal schizophrenia; (4) OCT indices related to visual...
Aim This study aimed to evaluate a pilot cross-sector initiative - bringing together public health, community group, primary mental health teams and patients in using co-production approaches deliver service meet the needs of black minority ethnic communities.Black communities continue face inequalities access provision. They are under-represented low-level interventions as they less likely be referred, more disengage from mainstream services. Effective models that lead improved better...
Surgical treatment of supracondylar fractures the femur has become commonplace. A variety surgical implants are available. In carefully chosen patients treated with appropriate technique, early motion and good knee function can be obtained open reduction internal fixation. However, morbidity (and mortality) substantial following complications fixation femur. We present a series 30 consecutive referred to Rancho Los Amigos Medical Center for fractures. Three septic pseudarthrosis underwent...
Urge urinary incontinence is the involuntary leakage of urine commonly occurring in older adults, particularly women. Preclinical evidence suggests that urge may occur due to up-regulation tachykinin mediated bladder/spinal reflex signaling. This study tested hypothesis aprepitant, a neurokinin-1 receptor antagonist, be efficacious treatment incontinence.This was double-blind, randomized, placebo controlled, parallel group pilot which postmenopausal women with history or mixed (with...
Introduction: Femoral/tibial lengthening with a telescopic, magnetically-powered, intramedullary nail is an alternative to external fixation.
In the UK, life expectancy for people living with a serious mental illness, such as schizophrenia and bipolar disorder, is reduced by 15–20 years compared general population. recent years, evidence based guidelines/policies designed to improve their physical health have been published, yet gap remains between recommendations practice. This case study describes how guidelines support were implemented using quality improvement approach. A quasi-experimental explored systems processes assessing...
Fifteen patients with actively draining septic nonunions were treated by a two-stage protocol consisting of (1) thorough and, if necessary, repeated debridement nonviable bone, necrotic soft tissue, and dense scar tissue followed stabilization an external skeletal fixator; (2) transplantation cancellous bone into the exposed after it had become lined granulation tissue. The graft, only fresh autogenous is kept moist physiologic irrigating solution throughout stages healing. fractures...
Sickle cell disease (SCD) is a cause of frequent emergency readmissions. We examined trends in SCD readmissions and inpatient mortality England relation to socio-economic status. Data from Hospital Episode Statistics were extracted for all patients admitted 2005/06. The financial year 2005/06 was taken as the index analysis. calculated readmission rates with primary or secondary diagnosis sickle anaemia crisis without during subsequent 5 years (2006/07–2010/11). Charlson Score used measure...