A5107306637- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- RNA Research and Splicing
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Antifungal resistance and susceptibility
- Colorectal and Anal Carcinomas
- Polyamine Metabolism and Applications
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Actinomycetales infections and treatment
- Immune cells in cancer
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Inflammation biomarkers and pathways
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
- Virus-based gene therapy research
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
University of Science and Technology of China
2020-2024
First Hospital of Jiaxing
2024
Yinchuan First People's Hospital
2023
Wenzhou Medical University
2022
Zhejiang Taizhou Hospital
2022
Anhui Provincial Hospital
2013-2021
Anhui Medical University
2016-2021
Cervical cancer is one of the most common female cancers worldwide. Although therapeutic outcomes patients with early-stage cervical have been significantly improved in past decades, tumor metastasis and recurrence remain major causes cancer-related deaths. In squamous cell carcinoma (SCC), aberrant activation epithelial-mesenchymal transition (EMT), a crucial process invasion epithelial cancer, could promote lymph nodal recurrence, predicts poor prognosis. this study, we show that...
Uterine Corpus Endometrial Carcinoma (UCEC) is one of the most common malignancies female genital tract and there remains a major public health problem. Although significant progress has been made in explaining progression UCEC, it still warranted that molecular mechanisms underlying tumorigenesis UCEC are to be elucidated. The aim current study was investigate key modules hub genes related pathogenesis, explore potential biomarkers therapeutic targets for UCEC. RNA-seq dataset corresponding...
Currently, the commonly used surgical methods for cervical lesions include loop electrosurgical excision procedure (LEEP) and cold knife conization (CKC). However, positive rate of margins after LEEP is relatively high, which leads to disease recurrence places further demand on clinical treatment. This study investigated factors related established a scoring system enhance preoperative risk assessment selection.A retrospective analysis data 411 patients undergoing surgery in First Affiliated...
Abstract Aim To establish a risk‐scoring system for lymph node metastasis (LNM) of early‐stage endometrial carcinoma (EC), and to stratify the preoperative risk LNM. Methods We retrospectively analyzed clinical data 507 patients diagnosed with EC (i.e., confined uterine corpus). determined factors LNM by logistic regression analysis; then constructed simple scoring system, an additive based on coefficient ( β ), odds ratio, each variable, respectively. Results The overall rate was 9.1%...
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Background: The underlying mechanism for post-operative relapse of non-small cell lung cancer (NSCLC) remained poorly understood. There is an urgent need to predict the risk recurrence NSCLC.Methods: We enrolled 57 stage I NSCLC patients with or without and performed whole-exome RNA sequencing on available primary recurrent tumors as well matched tumor adjacent tissues (TATs). LASSO regression was establish a prognostic classifier distinguishing patient high relapse.Findings: Primary from...
The causes of ovarian cancer (OC) have been confirmed to be closely related genetic factors. Identifying sequence variants hereditary (HOC) susceptibility genes can increase clinical surveillance, facilitate early detection, and provide personalized treatment for patients. This study is aimed at investigating the variation frequency HOC in Chinese population providing information etiology genetics OC.118 epithelial OC patients were recruited this study. Variants 18-gene panel detected blood...
Objective: To investigate the effect and clinical significance of myeloid-derived suppressor cells (MDSCs) levels serum miRNA-21 expression in advanced non-small cell lung cancer (NSCLC) patients. Methods: Advanced NSCLC patients treated at First People’s Hospital Tongxiang City, Zhejiang Province, between July 2021 June 2022 were included this study. MDSCs peripheral circulation assessed by flow cytometry, was q-PCR. The effects on MDSC proliferation ARG-1 inducible nitric oxide synthase...
Purpose: To evaluate the possible effects of C1q/tumor necrosis factor (TNF)-associated protein 6 (CTRP6) on postoperative cognitive dysfunction (POCD), including potentially-related signaling pathway.Methods: Behavioral analysis and impairment were assessed in each group. Immunoblots used to determine level CTRP6 following sevoflurane-induced nerve injury. Hippocampal neurons identified using Nissl staining, while inflammatory response neuronal injury was monitored by enzyme-linked...