A5076735785- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Salmonella and Campylobacter epidemiology
- Animal Genetics and Reproduction
- Eosinophilic Esophagitis
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Microscopic Colitis
- Herpesvirus Infections and Treatments
- Chemical Analysis and Environmental Impact
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
First Hospital of Lanzhou University
2018-2024
Lanzhou University
2009-2024
Chinese Academy of Sciences
2024
Jining Medical University
2024
Wuhan Institute of Virology
2024
Louisiana State University in Shreveport
2023
Sichuan Agricultural University
2019-2023
Capital Medical University
2017-2023
Capital University
2021-2023
Gansu Agricultural University
2009-2023
Peptides and proteins encoded by noncanonical open reading frames (ORFs) of circRNAs have recently been recognized to play important roles in disease progression, but the biological functions mechanisms these peptides are largely unknown. Here, we identified a potential coding circular RNA, circTRIM1, that was upregulated doxorubicin-resistant TNBC cells intersecting transcriptome translatome RNA-seq data, its expression correlated with clinicopathological characteristics poor prognosis...
The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is need develop more effective and safer virus (MPXV)-specific vaccines in response epidemic. mRNA vaccine promising platform protect against MPXV infection. In this study, we construct two bivalent vaccines, designated LBA (B6R-A29L) LAM (A35R-M1R), quadrivalent vaccine, LBAAM (B6R-A35R-A29L-M1R). immunogenicity protective efficacy these alone or...
MicroRNAs (miRNAs) are small non-coding RNAs affecting the expression of target genes via translational repression or mRNA degradation mechanisms. With increasing availability and miRNA data, it might be possible to assess functional targets using fact that a down-regulate its mRNAs. In this work we computed correlation profiles between miRNAs mRNAs NCI-60 data. The aim is investigate whether correlations profiles, either positive negative, can used assist identification miRNA-mRNA...
Abstract Triple‐negative breast cancer (TNBC) is the most malignant subtype of cancer. TP53, which has a mutation rate ≈70%–80% in TNBC patients, plays oncogenic roles when mutated. However, whether circRNAs can exert their effects on through regulating mutant TP53 not been well evaluated. In this study, circCFL1, highly expressed cells and tissues prognostic potential identified. Functionally, circCFL1 promoted proliferation, metastasis stemness cells. Mechanistically, acted as scaffold to...
Abstract Background MicroRNAs (miRNAs) are a set of small non-coding RNAs serving as important negative gene regulators. In animals, miRNAs turn down protein translation by binding to the 3' UTR regions target genes with imperfect complementary pairing. The identification microRNA targets has become one major challenges miRNA research. Bioinformatics investigations on have resulted in number prediction tools. Although these tools capable predicting hundreds for given miRNA, many them suffer...
Heat-stress cognate 70 (Hsc70) is a host protein required for hepatitis B virus (HBV) replication, and oxymatrine (1) suppresses Hsc70 expression. Taking as target against HBV, 22 analogues of 1 defined with substituents at position 1, 13, or 14 were synthesized evaluated their activity on mRNA The SAR revealed that (i) the oxygen atom 1-position was not essential, (ii) increasing electron density ring D reduced activity, (iii) introducing proper substituent 13- and/or 14-position(s),...
Abstract An electrochemical sensor utilizing Au-Ni@ etched metal-organic framework (etched MOF) on a glassy carbon electrode (GCE) was constructed for ultrasensitive detection of 3-nitrophenol (3-NP). The Au-Ni@etched MOF in situ nanocomposite synthesized via simple one-step process that combines the etching Ni-hemin with simultaneous electrodeposition Au-Ni bimetallic nanoparticles. not only provides abundant active sites adsorbing 3-NP, but also serves as supporter loading This innovative...
Heat stress cognate 70 (Hsc70) is a host protein associated with hepatitis B virus (HBV) replication. The goal of this study was to investigate whether Hsc70 could be an anti-HBV drug target. Our results showed that introducing increased HBV replication in HBV(+) human hepatocytes (HepG2.2.15 cells). coiled-coil region on (nucleotides 1533 1608; amino acids 511 536) the key sequence for Knockdown expression by RNA interference (RNAi) largely inhibited no cytotoxicity host. Using mRNA...
The aim of the present study was to screen for and identify microRNAs (miRNAs/miRs) that are associated with gastric cancer clarify role these miRNAs in cancer. Thus, differential expression a panel two pairs tissues their matched adjacent healthy investigated by performing microarray analysis. To verify results this screen, 56 were analyzed selected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). association between specific miRNA clinical data relating tissue...
To evaluate the prevalence of Helicobacter pylori infection and risk factors to serotype strains in Wuwei, located north-western China, which has a high incidence gastric cancer. was analysed 21 291 adults by 14 C-urea breath test, H. antibody were detected 9183 serum samples latex immunoturbidimetric method. The correlation with demographic-economic, lifestyle medical history among participants determined questionnaire. antibodies against urease, VacA CagA dot immunobinding assay. rate...
Host cellular factor apolipoprotein B messenger RNA (mRNA)-editing enzyme catalytic polypeptide-like 3G (hA3G) is a cytidine deaminase that inhibits group of viruses including human immunodeficiency virus-1 (HIV-1). In the continuation our research on hA3G, we found hA3G stabilizing compounds significantly inhibited hepatitis C virus (HCV) replication. Therefore, this study investigated role in HCV Introduction external into HCV-infected Huh7.5 hepatocytes replication; knockdown endogenous...