A5101574416- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Cytomegalovirus and herpesvirus research
- Reproductive Biology and Fertility
- Cardiovascular Health and Disease Prevention
- Immune Cell Function and Interaction
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetics and Neurodevelopmental Disorders
- Medicinal Plants and Neuroprotection
- RNA modifications and cancer
- HIV Research and Treatment
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Sperm and Testicular Function
First Affiliated Hospital of Zhengzhou University
2015-2025
Fujian Provincial People's Hospital
2025
Fujian University of Traditional Chinese Medicine
2025
Chongqing University
2024-2025
Affiliated Hospital of North Sichuan Medical College
2024
Third Affiliated Hospital of Zhengzhou University
2022-2024
Chongqing Public Health Medical Center
2019-2023
Hainan University
2022-2023
Shaoxing University
2011-2023
Peking University
2023
Salidroside, a natural active ingredient extracted from Rhodiola rosea, has been shown to exert antitumor activity against breast cancer Dong Young et al. [1], colon Sun [2] and bladder Tian [3]. However, the effect of salidroside on apoptosis autophagy in gastric remains unclear. In our research, we observed biological human AGS cells. Our results demonstrated that inhibited growth cells both vivo vitro exerted proapoptotic as confirmed by flow cytometry, Hoechst staining western blot...
Abstract The Solar Upper Transition Region Imager (SUTRI) onboard the Space Advanced Technology demonstration satellite (SATech-01), which was launched to a Sun-synchronous orbit at height of ∼500 km in 2022 July, aims test on-orbit performance our newly developed Sc/Si multi-layer reflecting mirror and 2k×2k EUV CMOS imaging camera take full-disk solar images Ne vii 46.5 nm spectral line with filter width ∼3 nm. SUTRI employs Ritchey–Chrétien optical system an aperture 18 cm. observations...
Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as potential biomarker of acute myocardial infarction. However, the relationship between and severity CAD remains unknown. This study was designed test whether circulating levels are associated with CAD. Methods: The present enrolled 40 patients who had risk factors for without angiographically significant CAD, 110 presenting stable angina...
Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology vast majority remains unclear. Here we describe three with primary multiple morphological abnormalities sperm flagella (MMAF) from two unrelated Han Chinese families. We performed whole-exome sequencing (WES) and Sanger on proband family 1, found that he carried novel compound heterozygous missense mutations in dynein axonemal heavy chain 6 (DNAH6) resulted substitution a...
Angiotensin II (AngII)-induced production of inflammatory factors and proliferation in vascular smooth muscle cells (VSMCs) play an important role the progression atherosclerotic plaques. Growing evidence has demonstrated that activation peroxisome proliferator-activated receptor-γ (PPAR-γ) effectively attenuates AngII-induced inflammation intercellular reactive oxygen species (iROS) production. Curcumin (Cur) inhibits responses by enhancing PPAR-γ activity reducing oxidative stress various...
Metastasis is the leading cause of death in patients with breast cancer and aberrantly expressed microRNAs (miRNAs) are highly associated this process. A previous study has shown that miR-335 downregulated can suppress tumor invasion metastasis. Emerging evidences indicate c-Met implicated cell scattering, migration, invasion. However, little known about relationship between expression alteration cancer. In present study, we found was protein upregulated two human lines. MiR-335 to...
Abstract The purpose of this study was to develop an lncRNA signature improve the prediction prognosis cervical cancer through integration bioinformatics and analysis TCGA RNA sequencing data. In study, we established a set four signatures that significantly associated with recurrence-free survival using Cox regression model. Functionally, screened CC-associated NCK1-AS1 as new candidate regulator which promotes development progression in CC. qRT-PCR situ hybridization (RISH) results showed...
Abstract Background Atrial fibrillation (AF), a supraventricular arrhythmia that impairs cardiac function, is main source of morbidity and mortality. Serum‐derived extracellular vesicles (EVs) have been identified to carry potential biomarker or target for the diagnosis treatment AF. We intended dissect out role lncRNA MIAT enriched in serum‐derived EVs Methods expression was quantified isolated from serum samples AF patients. Mouse cell models were developed after angiotensin II (Ang II)...
The triglyceride and glucose (TyG) index has been considered a simple surrogate marker of insulin resistance, related to high risk mortality. However, few studies have investigated the specific relationship between TyG all-cause mortality among population with cardiovascular diseases.2,072 participants diseases were enrolled from National Health Nutrition Examination Survey (NHANES) 1999-2014. was calculated as log [fasting triglycerides (mg/dL) x fasting (mg/dL)/2]. Outcomes baseline levels...
Background Currently, the clinical evidence regarding prognostic significance of TyG index in acute myocardial infarction (AMI) patients remains unclear. Our research analyzed correlation between and risk mortality with AMI, order to evaluate influence on prognosis this population. Methods 1205 ICU AMI were retrospective cohort analysis, necessary data obtained from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The study conducted Kaplan-Meier analysis compare all-cause...
Enterovirus 68 (EV-D68) is a non-enveloped virus with positive-sense single-stranded RNA genome that causes respiratory diseases and acute flaccid myelitis, posing significant threats to human health. However, an effective vaccine remains undeveloped. SIRT1, nicotinamide adenine dinucleotide (NAD+)-dependent enzyme, plays key role in cellular metabolism, but its interaction NAD+ during viral infections not well understood. In this study, through metabolomics analysis, we demonstrate EV-D68...
The association between the weight-adjusted waist index (WWI) and age-related macular degeneration (AMD) in US adults aged 40 years older is unknown. goal of this study was to ascertain a possible two. Data were obtained from National Health Nutrition Examination Survey (NHANES) 2005 2008. WWI calculated by dividing circumference (WC) square root body weight (kg). AMD diagnosed based on distinctive features observed fundus, using standard classification system. Weighted logistic regression...
Objectives Complications of intracranial hemorrhage (ICH) after percutaneous coronary intervention (PCI), although rare, have a poor prognosis with high mortality rates. This study aims to provide information on the clinical characteristics and outcomes hospitalized patients ICH PCI. Materials methods retrospective included 24 enrolled from February 2014 September 2023, which occurred during post-PCI hospitalization. We mainly analyzed general, procedural, features subsequent outcomes. In...
Objective With the intention of developing a more targeted control strategy for retinal vein occlusion (RVO) in East Asian populations, meta-analysis was conducted to evaluate risk factors associated with RVO this region. Methods PubMed, Web Science, Cochrane Library, CNKI, Wanfang and VIP databases were searched studies that reported Asia, published from establishment database May 2024. To further filter articles, Newcastle-Ottawa Scale (NOS) evaluation method utilized assess quality...
Background: Women infected with HIV are more likely to have aggressive cervical cancer, and patients infection often severely ill than those without infection.However, the underlying mechanism for progression of cancer is not yet fully understood requires further research.Methods: Exosomes were isolated from cell culture supernatants using differential ultracentrifugation.Confirmation exosome isolation was based upon identification by electron microscopy NanoSight particle tracking analysis...
The long non-coding RNA (lncRNA) SNHG3 has been shown to play oncogenic roles in several cancer types, but the mechanisms underlying its activity are poorly understood. In this study, we aimed explore clinical relevance and mechanistic role of gastric (GC). We found that expression GC cell lines tissues was significantly increased, upregulation lncRNA correlated with tumor stage decreased patient survival. Knocking down cells impaired proliferative, migratory, invasive vitro constrained vivo...
In humans, TDRD7 (tudor domain containing 7) mutations lead to a syndrome combining congenital cataracts (CCs) and non-obstructive azoospermia (NOA), characterized by abnormal lens development spermiogenesis. However, the molecular mechanism underlying TDRD7's functions in eye testicular are still largely unknown. Here, we show that depletion of this gene mice humans resulted accumulation autophagosomes disruption macroautophagic/autophagic flux. The disrupted autophagic flux tdrd7-deficient...
Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood. In this study, we examined of myricetin lipid accumulation macrophage atherosclerosis-prone low density lipoprotein receptor-deficient (Ldlr-/- ) mice.Ldlr-/- mice were fed an atherogenic diet supplemented with (0.15% diet, v/v) for 8 weeks. Body weight, adipose tissue food intake, serum biochemical parameters...