A5101738880- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Galectins and Cancer Biology
- Cardiovascular Health and Disease Prevention
- Tryptophan and brain disorders
- Cardiac Fibrosis and Remodeling
- Glycosylation and Glycoproteins Research
- Sodium Intake and Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Gastrointestinal motility and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Nanoplatforms for cancer theranostics
- Complement system in diseases
- Antimicrobial Peptides and Activities
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- Pancreatic function and diabetes
- Extracellular vesicles in disease
- Atrial Fibrillation Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Gut microbiota and health
- Venous Thromboembolism Diagnosis and Management
Sichuan Cancer Hospital
2025
University of Electronic Science and Technology of China
2025
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
First Affiliated Hospital of Zhengzhou University
2019-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Veterans Health Administration
2005
Background IgA nephropathy (IgAN) is the most common primary glomerular disease in world, and specific therapeutic methods for IgAN are limited. Telitacicept a humanized fusion protein composed of transmembrane activator calcium-modulating cyclophilin ligand interactor receptor human IgG.
Abstract Background Atrial fibrillation (AF), a supraventricular arrhythmia that impairs cardiac function, is main source of morbidity and mortality. Serum‐derived extracellular vesicles (EVs) have been identified to carry potential biomarker or target for the diagnosis treatment AF. We intended dissect out role lncRNA MIAT enriched in serum‐derived EVs Methods expression was quantified isolated from serum samples AF patients. Mouse cell models were developed after angiotensin II (Ang II)...
Abstract Aims The DELIVER study demonstrates a significant improvement in cardiovascular death or hospitalization for heart failure among with mildly reduced ejection fraction (HFmrEF) preserved (HFpEF).Cost‐utility of the adjunct use dapagliflozin to standard therapy patients HFpEF HFmrEF remains unclear. Methods and results A five‐state Markov mode was constructed project health clinical outcomes 65‐year‐old HFmrEF. cost‐utility analysis performed based on national statistical database....
Abstract Pancreatic ductal adenocarcinoma (PDAC), a very aggressive tumour, is currently the third leading cause of cancer‐related deaths. Unfortunately, many patients face issue inoperability at diagnostic phase to quite dismal prognosis. The onset metastatic processes has crucial role in elevated mortality rates linked PDAC. Individuals with advances receive only palliative therapy and have grim It essential carefully analyse intricacies process enhance prognosis for individuals Malignancy...
Objectives Complications of intracranial hemorrhage (ICH) after percutaneous coronary intervention (PCI), although rare, have a poor prognosis with high mortality rates. This study aims to provide information on the clinical characteristics and outcomes hospitalized patients ICH PCI. Materials methods retrospective included 24 enrolled from February 2014 September 2023, which occurred during post-PCI hospitalization. We mainly analyzed general, procedural, features subsequent outcomes. In...
The aim of this study was to explore the role IL-6-miR-210 in regulation Tregs function and atrial fibrosis fibrillation (AF). levels interleukin (IL)-6 IL-10 AF patients were detected by using ELISA. Proportions Treg cells fluorescence activated cell sorting analysis patients. expression Foxp3, α-SMA, collagen I III determined western blot. mechanocytes authenticated vimentin immunostaining. miR-210 performed quantitative real-time polymerase chain reaction (qRT-PCR). TargetScan used...
Objective: EMPEROR-Reduced and EMPEROR-Preserved studies showed the benefits of empagliflozin along with a reduction in cardiovascular death or hospitalisation for heart failure (HF). Our aim was to evaluate economics effectiveness adding standard therapy HF reduced ejection fraction (HFrEF) preserved (HFpEF) China. Methods: A multistate Markov model constructed yield clinical economic outcomes 65-year-old patients HFrEF HFpEF. cost-utility analysis conducted, mostly derived from study,...
Introduction: The diagnosis of Fabry disease (FD) with genetic variants unknown significance (VUSs) is relatively difficult. We explored patients novel VUS and concomitant immunoglobulin A nephropathy (IgAN) to improve the understanding VUS. Methods: study retrospectively investigated genetically confirmed FD. Probands were selected from database FD who underwent analysis. Demographic, clinicopathological, laboratory data probands family members collected analyzed. Results: Fourteen their...
We explored whether the nighttime blood pressure (BP) decline predicts renal function in a population-based cohort with primary hypertension. measured baseline ambulatory BP and glomerular filtration rate (GFR) of 1,042 hypertensive patients. repeated GFR measurements calculated after median follow-up 5.8 years. The estimated (eGFR) declined by -0.23 to -0.20 mL/min per year as systolic (SBP), diastolic (DBP), mean rates increased 1% (P < 0.001). In fully adjusted model, SBP, DBP, were all...
Objective To prepare IR780 and vincristine (VCR)-loaded poly(lactic-co-glycolic acid)(PLGA) nanoparticles (IR780-VPN) verify their specific targeting ability anti-proliferative efficiency in vitro. Methods IR780-VPN were prepared to detect basic physical chemical characteristics. SK-NEP1 cells used as a tumor cell model the of IR780-VPN. divided into six groups: group A: PBS; B: free VCR; C: PLGA nanoparticles; D: VCR-PLGA E: IR780-PLGA F: IR780-VPN. Results The average particle...