A5101835461- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and biosynthesis
- FOXO transcription factor regulation
- Plant Pathogens and Resistance
- Sirtuins and Resveratrol in Medicine
- PI3K/AKT/mTOR signaling in cancer
- Cellular transport and secretion
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Digestive system and related health
- Medical and Biological Ozone Research
- Phagocytosis and Immune Regulation
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
Guangxi Medical University
2008-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2019-2024
Nanjing Drum Tower Hospital
2024
First Affiliated Hospital of GuangXi Medical University
2008-2020
Whitehead Institute for Biomedical Research
1993-1995
GPI-linked protein molecules become Triton-insoluble during polarized sorting to the apical cell surface of epithelial cells. These insoluble complexes, enriched in cholesterol, glycolipids, and proteins, have been isolated by flotation on sucrose density gradients are thought contain putative GPI-sorting machinery. As cellular origin molecular components this complex remain unknown, we begun characterize these low-density complexes from MDCK We find that which represent 0.4-0.8% plasma...
A 22-kDa protein, caveolin, is localized to the cytoplasmic surface of plasma membrane specializations called caveolae. We have proposed that caveolin may function as a scaffolding protein organize and concentrate signaling molecules within Here, we show interacts with itself form homooligomers. Electron microscopic visualization these purified homooligomers demonstrates they appear individual spherical particles. By using recombinant expression glutathione S-transferase fusion defined...
Glycosyl-phosphatidylinositol (GPI)-linked proteins are transported to the apical surface of epithelial cells where they undergo cholesterol-dependent clustering in membrane micro-invaginations, termed caveolae or plasmalemmal vesicles. However, sorting machinery responsible for this caveolar-clustering mechanism remains unknown. Using transfected MDCK as a model system, we have identified complex cell molecules (80, 50, 40, 22-24, and 14 kD) that interact pH- fashion with an recombinant...
Although significant progress has been made in the diagnosis and treatment of gastric cancer, overall survival rate disease remains unchanged at approximately 20%‐25%. Thus, there is an urgent need for a better understanding molecular biology aspects hope discovering novel strategies. Recent years have witnessed decisive roles aberrant cancer cell metabolism maintenance malignant hallmarks cancers, regarded as target cancer. CDK 2, cycle‐dependent kinase that usually regulates cycle...
Abstract Pancreatic ductal adenocarcinoma (PDAC), a very aggressive tumour, is currently the third leading cause of cancer‐related deaths. Unfortunately, many patients face issue inoperability at diagnostic phase to quite dismal prognosis. The onset metastatic processes has crucial role in elevated mortality rates linked PDAC. Individuals with advances receive only palliative therapy and have grim It essential carefully analyse intricacies process enhance prognosis for individuals Malignancy...
miR-877-5p has been reported as a tumor suppressor in multiple cancers. Its role gastric cancer, however, remains unclear. Hence, the purpose of this study was to elucidate function, and underlying molecular mechanism, development cancer.We first analyzed expression using Gene Expression Omnibus (GEO) database detected its cancer epithelial cells via real-time quantitative PCR (qRT-PCR). We then assessed proliferation, apoptosis, cell cycling. The gene targeted by predicted bioinformatic...
The inhibitory roles of limonin have been revealed in various tumors. However, the and related mechanism hepatocellular carcinoma (HCC) progression are still confused. Here, we collected non-adherent spheroids formed by HCC cells found that proportion G0 phase was remarkably higher than cells. Additionally, increased EdU incorporation without affecting apoptosis spheroids. Notably, upon treatment, decreased S/G2/M increased. Furthermore, attenuated stemness cells, characterized as ALDH1...
Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor derived from intrahepatic bile duct epithelial cells. Accumulating studies report that microRNAs are widely involved in migration and metastasis by regulation of target genes. miR-7-5p has been confirmed to inhibit be related prognosis for several tumors. Our study investigated the underlying functions ICC.The expression ICC tissues but also cell lines was analyzed real-time PCR. By analyzing relationship between clinicopathological...
Background: International experts have put forward a new definition for metabolic dysfunction-associated fatty liver disease (MAFLD). Nonetheless, sex differences in MAFLD function hepatocellular carcinoma (HCC) survival is still unknown. Therefore, the current work focused on exploring gender-specific association of effect prognosis after radical resection cancer. Methods: The long-term prognostic outcomes 642 HCC patients undergoing hepatectomy were analyzed retrospectively. To calculate...
To investigate the role and underlying mechanisms of intercellular adhesion molecule-1 (ICAM-1) in migration mesenchymal stem cells (MSCs) patients with ankylosing spondylitis (AS).
Tracing new pests has two aims, to determine the entry pathway and potential for dispersal spread.Tracing pathways enables Ministry of Agriculture Forestry target risk goods inspection enhance Import Health Standards.Impatiens necrotic spot virus (INSV) was identified from freesias grown seed in a Christchurch nursery August 2003.INSV is not transmissible survey work tracing discovered link at sites between impatiens imported as tissue culture USA.However, this conclusive, since same tested...
To investigate the effects of interleukin-9 (IL-9) in activation hepatic stellate cells (HSCs) mice infected with Schistosoma japonicum.Primary HSCs were isolated from 7 weeks post-infection S. japonicum using situ liver perfusion and density gradient centrifugation, cultured vitro. randomly assigned to PBS control group IL-9 stimulation (stimulation 20 ng/mL IL-9). harvested 48 h 72 poststimulation, expression α-smooth muscle actin (α-SMA), type I collagen (Col I) III III) was determined...