A5100334353- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Moyamoya disease diagnosis and treatment
- Image Retrieval and Classification Techniques
- Phagocytosis and Immune Regulation
- Angiogenesis and VEGF in Cancer
- MRI in cancer diagnosis
- Traditional Chinese Medicine Analysis
- Bioinformatics and Genomic Networks
- Vascular Tumors and Angiosarcomas
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Heat shock proteins research
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- PI3K/AKT/mTOR signaling in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Meningioma and schwannoma management
- Cardiac Ischemia and Reperfusion
- Chronic Lymphocytic Leukemia Research
Capital Medical University
2010-2023
Institute of Computing Technology
2023
Beijing Tian Tan Hospital
2010-2023
University of Chinese Academy of Sciences
2023
Xiamen University
2023
Chinese Academy of Sciences
2023
Shihezi University
2023
Chinese Institute for Brain Research
2016-2022
National Clinical Research
2016-2022
Shanghai Sixth People's Hospital
2020-2022
Brain glioma is the most common primary intracranial tumor characterized by dismal prognosis and frequent recurrence, yet a real-time reliable biological approach to monitor response progression still lacking. Recently, few studies have reported that circulating cells (CTCs) could be detected in glioblastoma multiform (GBM), providing possibility of its application brain monitoring system. But limits exist, because detection rate CTCs low was exclusively limited high- grade gliomas. Here, we...
Abstract Background Tripartite motif-containing proteins (TRIM) play a crucial role in carcinogenesis. Little attention has been focused on the possible functions of TRIM6 Methods The expression levels were assessed colorectal cancer (CRC) samples. was knocked down CRC cell lines, and subjected to Cell counting kit-8 (CCK-8), bromodeoxyuridine (BrdU) incorporation cycle assays. Immunoprecipitation proteomics analysis performed identify potential associated TRIM6. Results up-regulated samples...
Glioblastoma multiforme (GBM) is the most frequently diagnosed intracranial malignant tumor in adults. Clinical studies have indicated that hyperbaric oxygen may improve prognosis and reduce complications glioma patients; however, specific mechanism by which this occurs remains unknown. The present study investigated direct effects of stimulation on constructing an transplanted model congenic C57BL/6J mice. Bioluminescent imaging (BLI) was used to assess growth GL261‑Luc cells vivo, while...
Background/Aims: Acute pancreatitis contributes to high mortality in patients, and miRNAs play a vital role the development of acute (AP), however, its precise biological remains largely elusive. Methods: To clarify potential mechanisms AP, we built mouse models mild (MAP) moderate/ severe (SAP). MiRNA microarray analysis Real-time quantitative PCR (qRT-PCR) were used analyze expression miRNA MAP/SAP. TargetScan software, dual-luciferase gene reporter assays Western blotting assess target...
Intervertebral disc degeneration (IVDD) is a main cause of low back pain that associated with extracellular matrix (ECM) degradation and inflammation. This study aims to investigate the role DNMT3B its regulatory mechanisms in IVDD. IVDD rat models were constructed followed by transfections oe-DNMT3B or oe-YAP order explore development After transfection, nucleus pulposus (NP) cells isolated transfected oe-DNMT3B, oe-TRPA1, si-YAP, oe-COX2 functions NP cells. was poorly expressed tissues...
Objective Hyperbaric oxygen (HBO) is an emerging complementary alternative medical approach in glioma treatment. However, its mode of action unknown, so this was investigated the present study. Methods We constructed intracranial model congenic C57BL/6J mice. Glioma growth under HBO stimulation assessed by bioluminescent imaging and magnetic resonance imaging. Flow cytometry direct effects on reactive species (ROS) signaling transplanted cells organs, quantified mature T subgroups tumors,...
Background This study was performed to investigate the correlation between CT perfusion with acetazolamide challenge and angiogenesis in C6 gliomas. Methods Thirty-two male Sprague-Dawley rats were evaluated. The divided randomly four groups: eight orthotopically implanted gliomas at 10-days old (Group A), 14-days B), 18-days C), injected normal saline served as controls. before after administration of acetazolamide. Changes parameters due calculated analyzed. Results Elevated carbon dioxide...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Cao Y, Chen Wang F, Long J. PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition Ras/JNK signalling pathway. Folia Neuropathologica. 2020;58(1):45-56. doi:10.5114/fn.2020.94006. APA Cao, Y., Chen, Wang, F., & Long, (2020). Neuropathologica, 58(1), 45-56. https://doi.org/10.5114/fn.2020.94006 Chicago Yiqiang, Yu Fei Yonggang and Jiang Long. 2020....
Abstract Background Myeloid Sarcoma with monocytic differentiation is rare and quite likely missed by surgical pathologists. However it frequently misdiagnosed because of its non-specific imaging histological pattern. Case presentation We report the case a 64-year-old woman gastric primary myeloid sarcoma differentiatio. Upper endoscopy revealed neoplastic growth at junction lesser curvature antrum. Except for slightly increased peripheral monocyte count, no abnormalities were found on...
Abstract Background: This study aims to explore the role and underlying mechanism of IDH1 R132H in growth, migration, glycolysis glioma cells. Methods: The alternation IDH1, HIF-1α, LDHA genes 283 LGG sample (TCGA database) was analyzed on cBioportal. expression these three tissues with mutation or wild type (IDH1-WT) normal brain also assessed using immunohistochemistry assay. In addition, U521 cells were transfected IDH1-WT proliferation migration vitro . Cell growth curve, Transwell...
Abstract Purpose: Accurate differentiation between glioma recurrence and radiation necrosis is crucial for the management of patients suspected after therapy. This study aims to develop a deep learning methodology automated discrimination using routine magnetic resonance imaging (MRI) scans. Method: We investigated 234 who underwent radiotherapy following resection presented with recurrent lesions during follow-up MRI examinations retrospectively. Routine 3D-MRI scans, including T1, T2, T1ce...
Abstract Purpose : The conventional examination of molecular characteristics for glioma requires surgical removal and could not be used in the surgery planning. aim is to develop a method previewing malignancy with regular structural MRI images. Methods: 52 patients frontal lobe (mean age 43.2±9.3 years, 34 male) 117 healthy controls 32.6±9.8 83 participated study. All underwent neurocognitive test examinations, including 1p/19q co-deletion, isocitrate dehydrogenase (IDH) mutation,...
Abstract Although every glioma patient varies in tumor size, location, histological grade and molecular biomarkers, structural abnormalities are commonly conducted a group-level, leading to the miss of individual atrophy. In this study, we introduced an individual-level abnormality detection method for patients proposed several novel indexes depict atrophy pattern. Forty-five frontal lobe fifty-two age-matched healthy controls participated study. All underwent neurocognitive test...