A5101732641- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA modifications and cancer
- Neuroscience and Neural Engineering
- Respiratory Support and Mechanisms
- Neurological disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bacterial biofilms and quorum sensing
- Hormonal Regulation and Hypertension
- RNA Interference and Gene Delivery
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and biosynthesis
- Phagocytosis and Immune Regulation
- Cardiac Health and Mental Health
- RNA and protein synthesis mechanisms
- Adrenal and Paraganglionic Tumors
- Nitric Oxide and Endothelin Effects
- Ubiquitin and proteasome pathways
- Heart Failure Treatment and Management
- Ferroptosis and cancer prognosis
- Apelin-related biomedical research
- Emergency and Acute Care Studies
Yanbian University
2025
Shanxi Medical University
2010-2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Kumamoto University
2024
Shanxi Fenyang Hospital
2024
Shanxi Academy of Medical Sciences
2023
Hunan Provincial People's Hospital
2011-2020
Hunan Normal University
2018-2020
First Hospital of Shanxi Medical University
2010-2019
Abstract Increasing evidence suggests that non-coding small RNAs (miRNAs) carried by exosomes (EXOs) play important roles in the development and treatment of polycystic ovary syndrome (PCOS). In this study, we demonstrate PCOS mouse serum-derived EXOs promote granulosa cells (GCs) ferroptosis, induce occurrence a PCOS-like phenotype vivo. Notably, EXO miRNA sequencing combined with vitro gain- loss-of-function assays revealed miR-128-3p, which is absent mice PCOS, regulates lipid...
Cardiac hypertrophy mainly predicts heart failure and is highly linked with sudden loss of lives. MicroRNAs (miRNAs) play essential roles in the development cardiac through binding to corresponding mRNA targets. In this study, order investigate two mature forms miRNA-195, miR-195-3p, miR-195-5p, vitro vivo models were established by applying angiotensin II (Ang II) H9c2 cardiomyocytes infusing chronic Ang mice, respectively. We found that miR-195-5p was evidently equally upregulated studies...
Accumulated studies showed that numerous microRNAs (miRNAs) were aberrantly expressed in human intrahepatic cholangiocarcinoma (ICC) and contributed to the tumorigenic processes. However, whether miR-129-2-3p is implicated ICC initiation progression still limited. Here, results revealed expression was notably decreased tissues cell lines, a low obviously associated with distant metastasis clinical stage. Exogenous evidently repressed proliferative invasive abilities of cells. Mechanistic...
Background/Aims: Acute pancreatitis contributes to high mortality in patients, and miRNAs play a vital role the development of acute (AP), however, its precise biological remains largely elusive. Methods: To clarify potential mechanisms AP, we built mouse models mild (MAP) moderate/ severe (SAP). MiRNA microarray analysis Real-time quantitative PCR (qRT-PCR) were used analyze expression miRNA MAP/SAP. TargetScan software, dual-luciferase gene reporter assays Western blotting assess target...
To elucidate the function of lncRNA RMRP in hypoxia-induced acute myocardial infarction (AMI) vitro and explore its underlying mechanism.Hypoxic injury was confirmed by measurement cell viability, LDH release, migration, invasion, apoptosis H9c2 cells. The interactions between miR-214-5p as well p53 were also investigated.Hypoxia treatment significantly induced damage cells, accompanied with up-regulation expressions. Transfection siRNA remarkably attenuated enhancing migration reducing...
Acute respiratory distress syndrome (ARDS) is the inflammatory disorder of lung most commonly caused by sepsis. It was hypothesized that treating with penehyclidine hydrochloride (PHC), a new type hyoscyamus drug, early in development sepsis could diminish dysfunction.Sprague-Dawley rats were divided into 4 groups: 1) control group; 2) sham-operated 3) cecal ligation and puncture (CLP) 4) PHC-treated group. One hour after CLP surgery, either untreated or treated PHC via intraperitoneal...
The Ankyrin repeat domain 49 (ANKRD49) is an evolutionarily conserved protein, which related to mediate protein–protein interaction. However, the function of ANKRD49 in human glioma remains elusive. Mining through Cancer Genome Atlas (TCGA) database, we found that expression was increased tissues and high strongly associated with disease grade poor overall survival. To investigate role malignant glioma, lentivirus expressing shRNA targetting constructed U251 U87 cells. We demonstrated...
<title>Abstract</title> Background Despite the growing attention towards efficacy of high-intensity interval training (HIIT) on elderly health, a consensus regarding pleiotropic effects HIIT in this population is yet to be reached. Previous studies have predominantly focused specific outcomes or particular groups, lacking comprehensive analysis. Objective We aimed conduct systematic evaluation impact body composition, cardiopulmonary function, and metabolic parameters older adults. Methods...
To investigate the effect of Tip30 on invasion and metastasis hepatoma cells.Recombinant plasmid pAAV-Tip30 was transfected to HepG2 cells by polylactic-coglycolic acid (PLGA) nanoparticles. RT-PCR used detect mRNA expression matrix metalloproteinases (MMP)-2, MMP-9 epidermal growth factor receptor (EGFR). MMP- 2 protein level in tumor tissue detected Western blot. The proliferation, evaluated MTS assay clone formation method. adhesion were Transwell migration assay, respectively.With blot,...
Objective To study the expression characteristics of serum antinuclear antibodies (ANA) in lymphoma patients as well their target antigens cells, and to explore possible relationship between ANA. Methods Indirect immunofluorescence was used detect ANA level 100 cases 200 population-based controls. Then investigated by means 1∶2 matched with logistic regression models. Results The positive rate higher than that control group [28% (28/100) vs. 7% (14/200)], a statistical...
Objective To investigate the changes of learning and memory ability after stimulated by subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's Disease (PD) rats. Methods 55 healthy male SD rats were randomly divided into normal control group (n=10), PD (n=15), sham (n=15) (n=15). Stimulation groups planted unilateral STN‐DBS. STN‐DBS was powered on 7 consecutive days at regular time, while Sham complied with same program except power The apomorphine rotation observed...
Objective To investigate the changes of learning and memory ability after being stimulated by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s Disease (PD) rats. Methods 60 healthy male SD rats were randomly divided into normal control group (n=15), PD sham group(n=15) (n=15). Stimulation groups planted unilateral STN-DBS. STN-DBS was powered on 7 consecutive days at regular time, while Sham complied with same process except power The apomorphine rotation observed...
Abstract Purpose A model for predicting the prognosis of patients with heart failure reduced left ventricular ejection fraction (HFrEF) is currently not available. This study aimed to develop an age-biomarker-clinical history prognostic index (ABC-PI) and validate it assessment individual prognosis. Patients methods total 5,974 HFrEF were enrolled 1,529 included in this after excluding missing values loss follow-up. Variables that significantly contributed prediction all-cause mortality...
Abstract Background Various health‐related quality‐of‐life (HRQOL) tools are used to evaluate patients with chronic respiratory failure (CRF), but there is a relative lack of available for the evaluation social support and treatment in these patients. The present study focused on development systematic patient‐reported outcome measure (PROM) tool use CRF. Methods CRF‐PROM scale conceptual framework item bank were generated after reviewing corresponding literature HRQOL scales, interviewing...