A5045328893- Thyroid Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Medical Imaging Techniques and Applications
- Glaucoma and retinal disorders
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- Prostate Cancer Treatment and Research
- Animal Virus Infections Studies
- Thyroid Disorders and Treatments
- Mycorrhizal Fungi and Plant Interactions
- Cancer Immunotherapy and Biomarkers
- Adrenal Hormones and Disorders
- Marine and coastal plant biology
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Pituitary Gland Disorders and Treatments
- Ophthalmology and Eye Disorders
Fourth Affiliated Hospital of Harbin Medical University
2020-2023
Harbin Medical University
2017-2023
Mae Fah Luang University
2023
Dali University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2020
The phase II/III study of donafenib was initiated when there no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the II study. We aimed to further evaluate antitumor activity safety RAIR-DTC.This multicenter, double-blind, placebo-controlled, III enrolled 191 RAIR-DTC randomized a ratio 2:1 (300 mg twice daily,...
During an investigation into lignicolous freshwater fungi from the plateau lakes in Yunnan Province, China, two fresh collections of Torula taxa were collected and examined morpholgically.Torulaluguhuensis is characterised by: conidiophores which are semi-macronematous mononematous, erect, septate, smooth, slightly flexuous pale brown; conidiogenous cells holoblastic, mono- to polyblastic, integrated, terminal, terminal or intercalary conidial chains, doliiform conidia branched acrogenous,...
Objective Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies and fifth common in women. Circular RNAs (circRNAs) have been shown to play vital functions cancers, but few studies focused on mechanism dysregulated circRNAs PTC. Methods Quantitative reverse transcription PCR was used measure circ-NCOR2 levels PTC tissues cell lines. The were examined by analysis using counting kit-8, clone forming, flow cytometry, Transwell experiments. Bioinformatic dual...
The objective of the present study was to observe therapeutic effect radiation delivered via a 32P source on Graves' ophthalmopathy. A32P solution injected into 10-ml vacuum flask held inside lead container. A window cut in lead, generating treatment beam. Radiation given four areas: upper and lower orbit (covering ~1/3 eyelid) inner outer canthus. Each site received 10 daily doses 20 cGy. Proptosis measured by an exophthalmometer palpebral aperture determined with ruler. Measurements were...
<div>Abstract<p>Purpose: The phase II/III study of donafenib was initiated when there no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the II study. We aimed to further evaluate antitumour activity safety RAIR-DTC patients. Patients Methods: This multicenter, double-blind, placebo-controlled, III...
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
The current study observed the percentage of peripheral blood (PB) CD4+CD25+ regulatory T cells (Tregs) and influence Tregs on proliferation naïve CD4 in patients with hyperthyroidism. Furthermore, preliminary discussions are presented action mechanism hyperthyroidism attacks. present identified that compared PB healthy control subjects, no significant changes were (P>0.05). For hyperthyroidism, exhibited significantly reduced inhibition decreased secretion capacity cytokines cells, those...
Murine double minute 2 (MDM2) is an oncogene that important in tumorigenesis, tumor metastasis and chemotherapy resistance. We aimed to synthesize a molecular imaging probe, 99m Tc-HYNIC-siRNA 1489, which could specifically bind MDM2. The [ Tc]HYNIC-siRNA 1489 probe provided effective way of assessing MDM2 expression via single-photon emission computed tomography.Three siRNAs were designed, their inhibitory efficiencies determined using western blots qRT-PCR. selected siRNA was labeled with...
<div>AbstractPurpose:<p>The phase II/III study of donafenib was initiated when there no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the II study. We aimed to further evaluate antitumor activity safety RAIR-DTC.</p>Patients Methods:<p>This multicenter, double-blind,...
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
<div>Abstract<p>Purpose: The phase II/III study of donafenib was initiated when there no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the II study. We aimed to further evaluate antitumour activity safety RAIR-DTC patients. Patients Methods: This multicenter, double-blind, placebo-controlled, III...
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
<div>AbstractPurpose:<p>The phase II/III study of donafenib was initiated when there no available treatment indicated for Chinese patients with progressive radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Donafenib, an oral tyrosine kinase inhibitor (TKI), showed good efficacy and tolerability in the II study. We aimed to further evaluate antitumor activity safety RAIR-DTC.</p>Patients Methods:<p>This multicenter, double-blind,...
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
<p>Figure S1: Thyroglobulin concentrations changes for individual patients with negative thyroglobulin antibody from baseline to the end of cycle 2.</p>
The Accepted Manuscript version of this article (published on 6 June 2017) was withdrawn 16 November 2017 at the request authors.
Abstract Background Murine double minute 2 (MDM2) is an oncogene that important for tumorigenesis, tumor metastasis and chemotherapy resistance. We aimed to synthesize a molecular imaging probe, 99m Tc-HYNIC-siRNA 1489, which could specifically bind MDM2. The [ Tc]HYNIC-siRNA 1489 probe provides effective way assess MDM2 expression via SPECT. Method: Three siRNAs were designed their inhibitory efficiencies tested using western blots qRT-PCR. selected siRNA was labeled with the radionuclide...