A5100402080- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Lymphoma Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Vitamin D Research Studies
- Cardiac electrophysiology and arrhythmias
- Multiple Sclerosis Research Studies
- Acupuncture Treatment Research Studies
- Acute Myocardial Infarction Research
- Lung Cancer Treatments and Mutations
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Pharmacological Effects of Natural Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Cardiac Arrhythmias and Treatments
- Healthcare and Venom Research
- Extracellular vesicles in disease
- Gastrointestinal motility and disorders
- Alcohol Consumption and Health Effects
- Cardiomyopathy and Myosin Studies
- Cytokine Signaling Pathways and Interactions
- Spinal Cord Injury Research
Henan University of Technology
2025
University of Electronic Science and Technology of China
2017-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Peking University
2024
Peking University International Hospital
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2017-2023
Shanghai Sixth People's Hospital
2020-2023
Shanghai Jiao Tong University
2020-2023
Nanjing University of Chinese Medicine
2023
We assessed CSF levels of the light chain subunit neurofilaments (NfL) at baseline and after fingolimod therapy or placebo in patients with relapsing-remitting multiple sclerosis (RRMS). Changes NfL were also correlated relapse MRI outcomes.CSF samples available, 12 months treatment initiation, from a subset 36 RRMS (fingolimod 0.5 mg: n = 9; 1.25 15; placebo: 12) participating 2-year, phase 3 Fingolimod (FTY720) Research Evaluating Effects Daily Oral Therapy Multiple Sclerosis (FREEDOMS)...
The absorption characteristics and oral bioavailability of three tea catechins, namely (-)-epicatechin (EC), gallate (ECG), (-)-epigallocatechin (EGCG), were assessed in this study. Male Sprague Dawley rats (210 - 230 g) received either an intravenous (i.v. 50 mg/kg) or (5000 dose decaffeinated catechin-fraction containing EC (5 %), EGCG (50 ECG (13 %). Concentrations the compounds plasma, urine, feces measured using HPLC. A non-compartmental approach was employed for pharmacokinetic...
Left-atrial (LA) fibrosis is an important feature of many atrial fibrillation (AF) substrates. The JAK-STAT system contributes to cardiac remodelling, but its role in AF unknown. Here we investigated changes AF-model and their potential contributions LA-fibrosis.LA-remodelling was studied dogs with heart failure (HF) induced by ventricular tachypacing (VTP, 240 bpm), mice left-ventricular (LV) dysfunction due myocardial infarction (MI). selective STAT-3 inhibitor S3I-201 administered...
Abstract Background/Aim Interpreting an electrocardiogram (ECG) is a vital skill for nurses in cardiology. This study aimed to evaluate the efficacy of bridge-in, objective, preassessment, participatory learning, post-assessment, and summary (BOPPPS) model, when combined with case-based learning (CBL), enhancing nursing students’ ECG interpretation capabilities. Materials & methods Nursing students were randomly divided into two groups: one utilizing BOPPPS model CBL (BOPPPS-CBL), other...
Aqueous enzymatic extraction (AEE) can simultaneously separate oil and protein. However, a stable O/W emulsion is present in the AEE process, which not favorable for extracting oils. This study optimized use of heptanoic octanoic acids demulsification aqueous extraction. The optimal condition demulsification, including fatty acid ratio 1:3 (heptanoic to acid) with 1.00% addition, reaction time 40 min, temperature 70 °C, solid-to-liquid 1:5, resulted rate 97.95% ± 0.03%. After particle size...
Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate effects Epac1-signalling on LA fibroblast (FB) function its potential role in HF-related remodelling.HF was induced adult male mongrel dogs ventricular tachypacing (VTP). Epac1-expression decreased LA-FBs within 12 h...
Irritable bowel syndrome (IBS) is a common functional disease characterized by chronic abdominal pain and changes in movements. Effective therapy for visceral hypersensitivity IBS patients remains challenging. This study investigated the roles of brain-derived neurotrophic factor (BDNF) tyrosine kinase receptor B (TrkB) effect ANA-12 (a selective antagonist TrkB) on an IBS-like rat model.An model was established through neonatal maternal separation (NMS), assessed electromyographic (EMG)...
Lumbar disc herniation (LDH) is a common cause for low back pain. In this study, we aimed to explore the effects of specific Lactobacillus paracasei ( L. ), S16 , on symptoms LDH using mouse model LDH. The results showed that treatment improved behavior, increased cell proliferation, and decreased apoptosis in mice. Moreover, alleviated aberrant inflammation response mice, which characterized by anti-inflammatory cytokines, pro-inflammatory percentage Th1 Th2 cells Th17/Treg ratio. 16S rRNA...
Detergent-resistant membranes contain signaling and integral membrane proteins that organize cholesterol-rich domains called lipid rafts. A subset of these detergent-resistant (DRM-H) exhibits a higher buoyant density (∼1.16 g/ml) because association with skeleton proteins, including actin, myosin II, 1G, fodrin, an actin- membrane-binding protein supervillin (Nebl, T., Pestonjamasp, K. N., Leszyk, J. D., Crowley, L., Oh, S. W., Luna, E. (2002) Biol. Chem. 277, 43399-43409). To characterize...
Abstract Myocardial infarction (MI) is the most common heart disease, and also, it one of leading causes death from cardiovascular disease. It well known that MI additional injury during blood flow restoration in ischaemic myocardium. Boeravinone B (BB) a well‐known antioxidant anti‐inflammatory drug. We investigated cardioprotective effect BB drug against isoproterenol (ISO)‐induced rats this experimental study, along with we analysed its underlying mechanism. Adult Sprague Dawley (SD) were...
Among circulating tumor cell enrichment strategies, immunomagnetic beads (IMBs) have received great attention due to their excellent performance. However, traditional strategies using IMBs normally require an additional mechanical stirring device fully mix the and specimens, this step may cause cellular damage. In study, by changing architecture motion trajectory control strategy of IMBs, floating microspheres (FIMMs) matching rotary magnetic manipulation were proposed achieve highly...
Abstract Background This study aimed to explored the effects of Cardiac Rhythm Identification for Simple People (CRISP) method with flipped classroom approach arrhythmia interpretation in electrocardiogram (ECG) by trainee nurses. Methods A total 120 nurses were enrolled and randomly divided into experimental group control using lecture-based learning method. We observed two methods ECG training investigated students’ attitudes toward teaching practices. Results After training, test scores...
Recent studies point to important interactions between proinflammatory cytokines and neurohumoral mediators in heart failure. Here we investigate the influence of beta-adrenergic system on factors sequelae viral myocarditis. In an experimental model with virus-infected BALB/c mice, studied acute chronic effects epinephrine propranolol myocardial morphology, cytokine gene expression, survival. mice were inoculated encephalomyocarditis virus (EMCV) or sham saline followed for 30 days....
Background: ECM proteins are instrumental for angiogenesis, which plays momentous roles during development and repair in various organs, including post cardiac insult. After a screening based on an open access RNA-seq database, we identified Nephronectin (NPNT), extracellular protein, might be involved myocardial infarction (MI). However, the specific impact of nephronectin MI remains elusive. Methods Results: In present study, established system overexpressing NPNT locally mouse heart by...
Objectives: During the pandemic, quarantine has led to lockdown of many physical educational institutions. Thus, massive open online courses (MOOCs) have become a more common choice for participants. MOOCs are often flagged as supplemental methods disparities caused by regional socioeconomic distribution. However, dissenters argue that can exacerbate digital divide. This study aimed compare participants' performance before and after outbreak COVID-19, analyze impact epidemic on education...
Background:Yiqi-Tongluo Capsule (YTC) is a Chinese traditional patent medicine that has been used in the treatment of myocardial ischemia (MI). However, its molecular mechanisms against MI have not clear. Methods: Network analysis and experimental verification were to explore potential YTC for treatment. Firstly, main components capsules targets these predicted by online databases. The related genes collected from Genecards Online Mendelian Inheritance Man (OMIM) drug disease intersected,...
Cardiac fibroblasts are crucial for scar formation and cardiac repair after myocardial infarction (MI).Collagen triple helix repeat containing 1 (CTHRC1), an extracellular matrix protein, is involved in the pathogenesis of vascular remodeling, bone formation, tumor progression.However, role underlying mechanism CTHRC1 post-MI wound not fully clear.Bioinformatics analysis demonstrated up-regulation ischemic injury.Serum levels were increased MI mice expression was up-regulated MI.In vitro...