A5055002146- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- High Altitude and Hypoxia
- Rheumatoid Arthritis Research and Therapies
- Genomics, phytochemicals, and oxidative stress
- Plant chemical constituents analysis
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Natural Compounds
- GABA and Rice Research
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Tryptophan and brain disorders
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Anorectal Disease Treatments and Outcomes
- interferon and immune responses
- Eicosanoids and Hypertension Pharmacology
- Sphingolipid Metabolism and Signaling
- Enhanced Recovery After Surgery
- Mitochondrial Function and Pathology
Chengdu University of Traditional Chinese Medicine
2020-2025
High-altitude cerebral edema (HACE) is a disorder caused by low pressure and hypoxia at high altitudes. Nevertheless, as of now, there still scarcity safe effective prevention treatment methods. The active component Ligusticum Chuanxiong, namely Ligustrazine hydrochloride (LH), has shown potential in the HACE due to its anti-inflammatory, antioxidant, neuroprotective effects nervous system disorders. Consequently, protective effect LH on mechanism need be further explored. Prior modeling, 90...
Zanthoxylum bungeanum pericarp is a commonly used herbal medicine in China with effects of anti-inflammatory and analgesic, improving learning memory ability, while hydroxy- α -sanshool (HAS) the most important active ingredient Z. pericarps. The purpose this study was to investigate neuroprotective effect HAS its related possible mechanisms using H 2 O -stimulated PC12 cell model. CCK-8 assay results showed that had significant protective on cells without obvious cytotoxicity normal cells....
Hydroxy-α-sanshool (HAS) improves cognitive dysfunction, but its structural instability has limited clinical application. The present study was conducted to investigate the optimal formulation of hydroxy-α-sanshool liposomes (HAS-LPs) and effect on ameliorating learning memory disorders in an Alzheimer's disease (AD) model.In this study, HAS prepared as HAS-LP using a thin film dispersion method. After selecting preparation conditions, characterized transmission electron microscopy (TEM) by...
Alzheimer's disease (AD) is a typical neurodegenerative disease, which occurs in the elderly population.
This study was designed to evaluate the protective effects of eleutheroside B (EB) in high-altitude-induced myocardial injury (HAMI) and unravel underlying molecular mechanisms. SD rats were used for vivo experiments. Following pretreatment with EB, exposed a hypobaric environment within chamber 48 h. Electrocardiograms, H&E staining, serum biochemical indices measured EB on HAMI. Immunofluorescence Western blotting utilized detect expression associated proteins. In parallel, hypoxic...
Background High altitude cerebral edema (HACE) is a condition where the central nervous system experiences severe impairment as result of sudden oxygen deprivation at high elevations. At present, effective measures for preventing and treating this are still lacking. Eleutheroside B (EB), primary natural active compound found in senticosus , has demonstrated various biological functions. It also shown significant potential addressing acute mountain sickness neurological disorders. However,...
Neurodegenerative diseases are neurological that characterized by neuronal degeneration and apoptosis; they threaten populations around the world place a great burden on social economy. Unfortunately, drugs currently used to treat neurodegenerative have obvious side effects, making them much less effective. Therefore, discovery of new safe effective is urgently needed. Zanthoxylum bungeanum Maxim. (ZBM) has long medicinal history in China can also be as food. ZBM contains many types chemical...
Guizhi-Shaoyao-Zhimu decoction (GSZD) is often applied to control rheumatoid arthritis (RA), gout, osteoarthritis, etc. In this study, bioinformatic analysis and experimental verification were used uncover the integral mechanism profile of GSZD against RA.The chemical compositions identified by UPLC-QTOF-MS/MS. MH7A cell model was established screen active compounds in GSZD, potential targets these predicted through online database retrieval. The differential expression genes (DEGs) synovial...
Background:Yiqi-Tongluo Capsule (YTC) is a Chinese traditional patent medicine that has been used in the treatment of myocardial ischemia (MI). However, its molecular mechanisms against MI have not clear. Methods: Network analysis and experimental verification were to explore potential YTC for treatment. Firstly, main components capsules targets these predicted by online databases. The related genes collected from Genecards Online Mendelian Inheritance Man (OMIM) drug disease intersected,...
Objective: This study was aimed to investigate the potential active components, targets and mechanisms of silkworm excrement (SE) in treatment type 2 diabetes mellitus (T D) based on THE network pharmacology combined with experimental verification. Methods: Firstly, inhibitory effects SE α-glucosidase were measured vitro. Then, components T D collected screened using bioinformatics databases. R language, Cytoscape, Perl software used screen visualize important targets, biological processes...