A5106233220- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Heart Failure Treatment and Management
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Cardiac Arrest and Resuscitation
- Lipoproteins and Cardiovascular Health
- Peptidase Inhibition and Analysis
- Pharmaceutical Practices and Patient Outcomes
- Pharmacology and Obesity Treatment
- Tissue Engineering and Regenerative Medicine
- Cardiac Health and Mental Health
- Sleep and related disorders
- Healthcare Technology and Patient Monitoring
- Viral Infections and Immunology Research
- Cardiovascular and Diving-Related Complications
- Diabetes Treatment and Management
Chang Gung Memorial Hospital
2013-2024
Chang Gung University
2007-2024
Weatherford College
2023
Linkou Chang Gung Memorial Hospital
2016-2022
Montreal Heart Institute
2012-2014
Université de Montréal
2012-2014
University of Groningen
2013
University Medical Center Groningen
2013
Ankara University
2013
Biotechnology Institute
2013
Atrial fibrillation (AF) is characterized by structural remodeling, contractile dysfunction, and AF progression. Histone deacetylases (HDACs) influence acetylation of both histones cytosolic proteins, thereby mediating epigenetic regulation influencing cell proteostasis. Because the exact function HDACs in unknown, we investigated their role experimental clinical models.Tachypacing HL-1 atrial cardiomyocytes Drosophila pupae hearts significantly impaired (amplitude Ca(2+) transients heart...
Introduction Fibroblasts are important in the atrial fibrillation (AF) substrate resulting from congestive heart failure (CHF). We previously noted changes vivo indices of fibroblast function a CHF dog model, but could not detect isolated cells. This study assessed CHF-induced phenotype fibroblasts freshly control versus dogs, and examined effects cell culture on these differences. Methods/Results Left-atrial were dogs (ventricular tachypacing 240 bpm×2 weeks). Freshly-isolated compared to...
Aims The ratio of transmitral early filling velocity (E) to diastolic tissue (E′) is a key function parameter. strain rate (E′sr) has been proposed as substitute for E′ in the E/E′ better estimation left ventricular (LV) pressure. This study aims assess predictive value combined E/E′sr and global longitudinal (GLS) prognosis systolic heart failure (SHF). Methods results We retrospectively analysed 330 SHF patients with an LV ejection fraction (LVEF) ≤ 40%. Study end points were defined...
In patients with heart failure (HF), anxiety or insomnia is prevalent and associated poor clinical outcomes. Benzodiazepines (BZDs) are one of the most commonly prescribed medications for in Taiwan. Evidence regarding effects BZDs on reduced ejection fraction (HFrEF) inconclusive.To evaluate whether can mitigate adverse prognosis HFrEF.Patients HFrEF were identified from Chang Gung Research Database between January 1, 2007 December 31, 2018. Those who received BZD prescriptions defined as...
According to recent literatures, myocarditis is an uncommon side effect of mRNA vaccines against COVID-19. On the other hand, after adenovirus based vaccine rarely reported. Here we report a middle-aged healthy female who had acute fulminant perimyocarditis onset 2 days first dose ChAdOx1 (AstraZeneca) without any identified etiology. Detailed clinical presentation, serial ECGs, cardiac MRI, and laboratory data were included in report. Possible mechanisms adenoviral was reviewed discussed....
There are several causes for ST segment abnormalities in leads V1 to V3. Hypercalcaemia and Brugada syndrome among them. Both known produce ventricular arrhythmia, albeit only rare cases have been reported with documented evidence of arrhythmias association a hypercalcaemic crisis but none when coexists syndrome. We describe patient primary hyperparathyroidism who presented fibrillation, the ECG showed changes similar The provocation test flecainide was conducted twice. This positive, both...
The impact of door-to-balloon (DTB) time on patient outcomes is unclear in a Taiwanese population receiving primary percutaneous coronary intervention (PCI). study aimed to investigate the relationship between stratified DTB times and through analysis database from Taiwan acute syndrome full spectrum registry.Relevant data were collected case report forms patients PCI who categorized as group 1, 2, 3, 4 according < 45, 45-90, 91-135, > 135 minutes, respectively. differences analyzed by using...
In-hospital cardiac arrest is a serious issue for hospitalized patients. The documented initial rhythm and detected medical events have been reported to influence the survival of cardiopulmonary resuscitation. This study aimed identify effect continuous real-time electrocardiogram (ECG) monitoring on prognosis resuscitated patients in general ward. We conducted this retrospective using records cardiovascular ward who experienced an in-hospital received resuscitation from February 2015...
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a serious disease with high mortality but its management limited. The aim of this study was to investigate specific target sites for therapy in order find potential strategies CPVT. Methods and Results: mutant Ryanodine receptor 2 (RyR2) reduced stored-overloaded-induced Ca2+ release (SOICR) threshold incorporated into the Luo-Rudy dynamic (LRd) cell model elucidate underlying pathologies simulations reveal that...
Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are important risk factors for cardiovascular (CV) diseases. Although treating these simultaneously is recommended by current guidelines, only short-term clinical results available.To examine the longer-term efficacy safety of fixed-dose combination (FDC) versus free amlodipine atorvastatin in patients with concomitant hypertension hypercholesterolemia.Patients hypercholesterolemia were stratified into three groups [FDC 5...
Background Previous studies have shown that global constructive work (CW) and wasted (WW) predict response to cardiac resynchronization therapy (CRT). This study evaluated the predictive value of regional CW WW for reverse remodeling clinical outcomes after CRT. Methods We performed a prospective involving 134 CRT candidates with left bundle branch block ventricular ejection fraction ≤35%. Global were calculated using pressure-strain loop analysis. was defined by as reduction ≥15% in...
Sick sinus syndrome with symptomatic bradycardia is an indication for a permanent pacemaker. Either single (AAIR) or dual-chamber (DDDR) pacemaker can be implanted in these patients normal atrioventricular nodal function. This report presents 92-year-old male right ventricular apical pacing related recurrent acute pulmonary edema and mechanical asynchrony demonstrated by three-dimensional echocardiogram. Although echocardiography has been available many years, it seldom applied to evaluate...
Background: Heart failure (HF) causes differential remodeling of left atrium (LA) vs ventricle (LV), with much more prominent fibrosis in LA. Fibroblasts (FB) are central fibrotic responses, microRNAs (miRs) important regulators. This study determined the profile miR expression changes underlying LA/LV remodeling, as well FB/cardiomyocyte (CM) selectivity during development experimental HF. Methods: HF was induced dogs by ventricular tachypacing (240 bpm) for 0 (CTL), 12, 24 hrs, 1 and 2 wks...