A5100426743- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Bacterial Infections and Vaccines
- Psoriasis: Treatment and Pathogenesis
- Infections and bacterial resistance
- Liver physiology and pathology
- Antibiotic Use and Resistance
- Systemic Lupus Erythematosus Research
- Enterobacteriaceae and Cronobacter Research
- Glycosylation and Glycoproteins Research
- interferon and immune responses
- Fungal Infections and Studies
- Antimicrobial Peptides and Activities
- Antifungal resistance and susceptibility
- Urinary Tract Infections Management
- Bacterial biofilms and quorum sensing
Chinese PLA General Hospital
2024-2025
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Shenzhen Third People’s Hospital
2024
Wuhan University
2023
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2005-2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2009-2019
Chongqing Medical University
2010-2019
Jinzhou Medical University
2015
General Hospital of Shenyang Military Region
2015
Adaptation to selective pressures is crucial for clinically important pathogens establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat public health. In this study we analyzed genome sequences 794 CRKP bloodstream isolates collected in 40 hospitals China between 2014 and 2019. We uncovered subclonal replacement predominant clone ST11, where previously prevalent...
In this first national bloodstream infection (BSI) surveillance program in China, we assessed the composition of pathogenic bacteria and trends for antimicrobial susceptibility over a 6-year period China.Blood bacterial isolates from patients at hospitals participating Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected January 2014 to December 2019. Only isolate species per patient was eligible full study period. Antibiotic-susceptibility testing conducted by...
Background Simultaneous resistance to aminoglycosides and fluoroquinolones in carbapeneme non-susceptible (CNS) isolates will inevitably create problems. The present study was performed characterize the prevalence of plasmid-mediated quinolone determinants (QRDs) aminoglycoside (ARDs) among CNS Enterobacter cloacae (E. cloacae) a Chinese teaching hospital, acquire their molecular epidemiological characteristics. Methods β-lactamases genes (including class A carbapenemase blaKPC blaSME,...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated phenotypes and MDR CRKP identified their clonal characteristics.PCR sequencing were utilized to identify antibiotic determinants. Integron gene cassette arrays determined by restriction fragment length polymorphism (RFLP) analysis. Multi-locus sequence typing (MLST) pulsed-field gel electrophoresis...
Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with (PLWH) fail to achieve an optimal recovery CD4 T cells, and precise metabolic regulation underlying immune remained poorly understood. In this cross-sectional study, mass spectrometry was used for quantitative analysis plasma metabolome lipidome 24 treatment-naïve PLWH (TNs), 33 immunological responders (IRs), 35 non-responders (INRs), 16 healthy controls (HCs). The data were...
People living with HIV (PLWH) exhibit accelerated aging, characterized by systemic inflammation, termed "inflammaging." While T-cell expansion is prevalent in PLWH, its connection to inflammaging remains unclear. In this study, we analyzed the TCRβ repertoire of 257 healthy controls (HC) and 228 revealing pronounced T cell clonal PLWH. The was only partially reversed following antiretroviral therapy (ART) closely associated ART duration, CD4+ CD8+ counts CD4/CD8 ratio. TCR-based age modeling...
Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden country and prepare for HPV-based screening program further vaccination of China. This study is a pooled analysis from five years Chongqing China, which cross-sectional design using collecting. The positivity was 26.2% (10542/40311), single type 25.7% (10360/40311), multiple 8.2% (3306/40311), high-risk 30.9% (12490/40311), low-risk 2.9%(1169/40311). most common genotypes...
Cytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients investigated the clinical significance these changes. IL-27 a cellular factor regulates differentiation CD4+ cells, which can secrete interleukin-10 (IL-10) interleukin-17 (IL-17) vivo. Concentrations serum 67 RA patients, 36 sex- age-matched control...
Invasive candidiasis (IC) is the most common cause of invasive fungal infections. Identification risk factors for such infection may help in empirical therapeutic decision-making process. We conducted this study to characterize clinical epidemiology and differentiate between Candida albicans non-albicans species. retrospectively evaluated patients with IC from 2011 2013. Clinical data, antibiotic therapy, underlying condition, procedures were analyzed compared C. was frequently isolated...
We compared the performance of modified Hodge test (MHT), Triton (THT), Carba NP (CNPt), simplified (CNPt-direct), blue-Carba (BCT), and carbapenem inactivation method (CIM) for rapid accurate carbapenemase detection.The methods were evaluated by using 256 gram-negative isolates, including 197 Enterobacteriaceae (79 Enterobacter spp., 74 Klebsiella 33 Escherichia coli, 10 Citrobacter 1 Serratia marcescens), 51 Acinetobacter baumannii, 8 Pseudomonas aeruginosa strains. The collection included...
Sepsis is a devastating condition with high mortality rate and limited treatments. characterized by failed host immune response to contain the infection, resulting in organ dysfunction. Interleukin-34 new cytokine involved infection immunity. Whether interleukin-34 beneficial or deleterious sepsis underlying mechanisms remains unknown.Prospective randomized animal investigation vitro studies.Research laboratory at university hospital.Wild-type C57BL/6 mice were used for vivo studies, septic...
Carbapenem-resistant Enterobacteriaceae (CRE) has been considered a serious global threat, but carbapenem resistance remains relatively uncommon in E. cloacae, especially China. The aim of this study was to characterize carbapenem-resistant cloacae (CR-ECL) isolates from 2012 2016 Southwest Our revealed that 20 (15.2%) the 132 CR-ECL obtained patients were identified as NDM-1, with most carrying IncFIIA plasmids. Notably, we initially observed strain co-harbored NDM-1 and IMP-8...
We report the first occurrence of New Delhi metallo-β-lactamase 5 (NDM-5) in carbapenem-resistant Escherichia coli isolated from blood cultures three leukemia patients northern China. These had at some time been hospitalized hematology department same hospital. All isolates were ST167 with identical pulsed-field gel electrophoresis patterns, suggesting a likely hospital transmission.
Progranulin (PGRN) is an important immunomodulatory factor in a variety of inflammatory diseases. However, its role pulmonary immunity against bacterial infection remains unknown.Pneumonia was induced PGRN-deficient and normal wild-type mice using Pseudomonas aeruginosa or Staphylococcus aureus, we assessed the effects PGRN on survival, burden, cytokine chemokine production, leukocyte recruitment after pneumonia.Patients with community-acquired pneumonia displayed elevated levels. Likewise,...
This study was aimed to identify the determinants of in-hospital mortality in Acinetobacter baumannii (A. baumannii) bacteremia and assess impact carbapenem resistance on mortality.A five-year case-control conducted from January 2011 December 2015 a tertiary teaching hospital with 3200 beds, Southwest China. Clinical outcomes potential patients nosocomial A. carbapenem-resistant (CRAB) were evaluated using Cox logistic regression analyses.A total 118 included. Seventy-one percent (84/118)...