A5045011649- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- Renal cell carcinoma treatment
- Mycobacterium research and diagnosis
- RNA Interference and Gene Delivery
- Parasite Biology and Host Interactions
- Turtle Biology and Conservation
- Protein Tyrosine Phosphatases
- Nanoplatforms for cancer theranostics
- Burkholderia infections and melioidosis
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- 14-3-3 protein interactions
- Genetic and Kidney Cyst Diseases
- Breast Lesions and Carcinomas
- Viral gastroenteritis research and epidemiology
Chongqing Medical University
2014-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2024
Inner Mongolia University for Nationalities
2019
BC Cancer Agency
2017
National Institute on Deafness and Other Communication Disorders
1997
Abstract Background Nosocomial carbapenemase-producing Enterobacterieceae (CPE) infections constitute a major global health concern and are associated with increased morbidity mortality. Rectal colonization CPE is risk factor for bacterial translocation leading to subsequent endogenous infections. This prospective observational study was aimed investigate the prevalence epidemiology of rectal CPE, carbapenemase genotypes, identify independent factors acquisition in high-risk patients from...
ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that paucity studies referred pediatric BSIs, our study aimed demonstrate the longitudinal distribution adult BSIs Southwest A multicenter retrospective surveillance was launched from 2012 2017. Data China Antimicrobial Resistance Surveillance System (CARSS) analyzed by Whonet 5.6 Graphpad Prism 6 Software....
This study was aimed to identify the determinants of in-hospital mortality in Acinetobacter baumannii (A. baumannii) bacteremia and assess impact carbapenem resistance on mortality.A five-year case-control conducted from January 2011 December 2015 a tertiary teaching hospital with 3200 beds, Southwest China. Clinical outcomes potential patients nosocomial A. carbapenem-resistant (CRAB) were evaluated using Cox logistic regression analyses.A total 118 included. Seventy-one percent (84/118)...
Detoxified-lipooligosaccharide (dLOS)-protein conjugates from nontypeable Haemophilus influenzae (NTHi) elicited a significant rise of anti-LOS antibodies with bactericidal activity in rabbits (X.-X. Gu, C.-M. Tsai, T. Ueyama, S. J. Barenkamp, B. Robbins, and D. Lim, Infect. Immun. 64:4047-4053, 1996). In this study, we evaluated whether vaccination the would protect against NTHi otitis media chinchillas. Fifty-eight chinchillas received three subcutaneous or intramuscular injections...
Abstract Background Clostridium difficile infection (CDI), especially hospital-acquired (HA-CDI), continues to be a public health problem and has aroused great concern worldwide for years. This study aimed elucidate the clinical epidemiological features of HA-CDI characteristics C.difficile isolates in Chongqing, Southwest China. Methods A case-control was performed identify incidence risk factors HA-CDI. C. were characterised by polymerase chain reaction (PCR) ribotyping, multilocus...
Abstract Background PD-1/PD-L1 blockade has become a powerful method to treat malignant tumors. However, large proportion of patients still do not benefit from this treatment, due low tumor immunogenicity and penetration the agents. Recently, neutrophil elastase been shown induce robust immunogenicity, while insufficient enzyme activity at site restricted its anti-tumor application. Here, we designed polyethyleneimine-modified (PEI-elastase) loaded with PD-L1small interfering RNA (PD-L1...
Co-evolution of host and aeromonads has diversified their spectrums diseases antibiograms, while a paucity data was concerning about this diversity in China. To fill gap, study aimed to investigate compare antimicrobial resistance (AMR) patterns clinically important Aeromonas spp. from various clinical sources.A multicenter retrospective surveillance conducted Chongqing 2011 2017. Data strains were retrieved the database China Antimicrobial Resistance Surveillance System (CARSS). Whonet 5.6...
To assess antimicrobial resistance profiles change in uropathogenic Escherichia coli (UPEC) during an 8-year period, especially extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant isolates.A retrospective observational study of urinary tract infections (UTIs) was performed a territory hospital between 2012 2019. Isolates were identified using matrix-assisted laser desorption/ionization time flight mass spectrometry or the VITEK 2 Compact system. The susceptibility testing...
To develop a rapid EDTA-modified carbapenem inactivation method (reCIM) combined with modified (mrCIM) to detect carbapenemase and distinguish metallo-β-lactamases from carbapenemases in Enterobacteriaceae 4 hrs.The sensitivities specificities of mrCIM reCIM were retrospectively evaluated 247 carbapenem-resistant which 107 producers confirmed by PCR sequencing. In addition, prospectively 47 enterobacterial isolates.The sensitivity specificity 96.3% 97.1% at 2.5 hrs post incubation, the...
Abstract Background: Neoadjuvant chemotherapy is a treatment option for breast cancer patients (pts) with locally advanced disease and pts operable who desire conservation. therapy also allows early evaluation of the effectiveness systemic therapy. Pathologic complete response (pCR) has been shown in clinical trials to be associated improved survival. The objective this study was determine if outcomes demonstrated can applied population based setting by comparing achieved pCR (no invasive...
Abstract Background: Data on the Antimicrobial resistance (AMR) trends of important clinical isolates in southwestern China is lacking. This study was conducted to monitor temporal AMR most common pathogens contributing majority human infections. Methods: A multi-center retrospective surveillance from 2012 2018. susceptibility testing carried out according unified protocols using Kirby-Bauer method or automated systems. Results were analyzed Clinical and Laboratory Standards Institute (CLSI)...