A5101981251- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Nitrogen and Sulfur Effects on Brassica
- Peptidase Inhibition and Analysis
- Pluripotent Stem Cells Research
- Galectins and Cancer Biology
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Glutathione Transferases and Polymorphisms
- Cytokine Signaling Pathways and Interactions
- Ferrocene Chemistry and Applications
- Kruppel-like factors research
- Genomics and Phylogenetic Studies
- Zebrafish Biomedical Research Applications
- Alzheimer's disease research and treatments
- Environmental DNA in Biodiversity Studies
- CRISPR and Genetic Engineering
- Alkaline Phosphatase Research Studies
- RNA modifications and cancer
- FOXO transcription factor regulation
- Protease and Inhibitor Mechanisms
Tianjin Normal University
2023-2025
Peking University
2007-2024
Yueyang Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Center for Life Sciences
2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
Fujian Medical University
2020-2024
Shihezi University
2014-2023
Institute of High Energy Physics
2023
Abstract Background Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and development innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-cancer effects, but action mechanisms are still unclear. Method MTT assays, colony-forming flow cytometry, scratch healing, transwell assays were used to evaluate proliferation, apoptosis, cell cycle, migration, invasion both ER-subtype cells. Xenograft experiments assess...
Invasion and metastasis are the major causes of death in patients with esophageal squamous cell carcinoma (ESCC). Epithelial-mesenchymal transition (EMT) is a critical step tumor progression transforming growth factor-β1 (TGF-β1) signaling has been shown to play an important role EMT. In this study, we investigated how TGF-β1 pathways contributed EMT three ESCC lines as well 100 nomadic ethnic Kazakhs residing northwest Xinjiang Province China. vitro analyses included Western blotting detect...
Abstract Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) prostate and breast cancer cells. However, its role esophageal squamous cell carcinoma (ESCC) not been studied. Here, we investigated the of dissemination ESCC. Expression was detected by immunohistochemistry tissue microarray 88 Kazakh ESCC patients. Western blotting performed to...
Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus intracellular barriers for successful pulmonary mRNA delivery. Apart from low delivery efficiency, nonnegligible toxicity is another common problem that impedes clinical application of many non-viral vectors. PEGylated cationic peptide-based vector a prospective approach enhance efficacy safety...
Chironomidae occupy a pivotal position within global aquatic ecosystems. The unique structural attributes of the mitochondrial genome provide profound insights and compelling evidence, underpinning morphological classification organisms substantially advancing our understanding phylogenetic relationships Chironomidae.
(1) Background: The insect mitogenome encodes essential genetic components and serves as an effective marker for molecular identification phylogenetic analysis in insects due to its small size, maternal inheritance, rapid evolution. morphological of Ablabesmyia is challenging, particularly non-experts. Thus, there increasing need data improve classification accuracy analysis. (2) Methods: Our encompassed eight species Ablabesmyia, a single Conchapelopia, one Denopelopia, Thienemannimyia, all...
Abstract Radiation‐induced heart disease is a serious side effect of radiation therapy that can lead to severe consequences. However, effective and safe methods for their prevention treatment are presently lacking. This study reports the crucial function fullerenols in protecting cardiomyocytes from injury. First, synthesized using simple base‐catalyzed method. Next, as‐prepared applied as an free radical scavenger broad‐spectrum antioxidant protect against X‐ray‐induced cardiomyocyte Their...
In worldwide, lung cancer has a major socio-economic impact and is one of the most common causes cancer-related deaths. Current therapies for are still quite unsatisfactory, urging alternative new treatments. Traditional Chinese Medicine (TCM) currently increasingly popular exhibits complicated intervention in cancers therapy. this study, we evaluated anti-tumor effect explored mechanisms TCM formula Yangyinwenyang (YYWY) non-small cell (NSCLC) models. YYWY induced apoptosis cells vitro....
Abstract Restenosis or occlusion after vascular procedures is ascribed to intimal hyperplasia. Transforming growth factor (TGF)-β1 involved in recruitment of mesenchymal stem cells (MSCs) following arterial injury and its release from latent TGF-binding protein by matrix metalloproteinase (MMP)-14-induced proteolysis contributes neointima formation. However, the relationship between MMP-14 TGF-β1 activation restenosis unknown. This study investigated using a rat model balloon-induced injury....
Non-small-cell lung cancer (NSCLC) is a major cause of worldwide death, posing challenge for effective treatment. Our previous findings showed that Chinese herbal medicine (CHM) QiDongNing (QDN) could upregulate the expression p53 and trigger cell apoptosis in NSCLC. Here, our objective was to investigate mechanisms QDN-induced enhancement. We chose A549 NCI-H460 cells validation vitro, LLC were applied form subcutaneous transplantation tumour model more depth. indicated QDN inhibited...
Various genomic and epigenetic modifications that occur during the development of cancer act as potential biomarkers for early diagnosis treatment. Previous studies have demonstrated abnormal expression claudin (CLDN) tight junction (TJ) proteins in numerous types human cancer. Reverse transcription‑quantitative polymerase chain reaction western blotting were employed to investigate variations CLDN TJ laryngeal non‑neoplastic tissues squamous carcinoma tissues. It was revealed CLDN2, CLDN4,...
Many studies have shown the Na+/K+-ATPase (NKA) might be a potential target for anticancer therapy. Cardiac glycosides (CGs), as family of naturally compounds, inhibited NKA activity. The present study investigates antitumor effect ouabain and elucidates pharmacological mechanisms CG activity in liver cancer HepG2 cell using SILAC coupled to LC–MS/MS method. Bioinformatics analysis 330 proteins that were changed cells under treatment with 0.5 μmol/L showed biological processes are associated...
Immunotoxins are Ab-cytotoxin chimeric molecules with mighty cytotoxicity. Programmed cell death 1-ligand 1 (PD-L1), is a transmembrane protein expressed mainly in inflammatory tumor tissues and plays pivotal role immune escape progression. Although PD-L1 checkpoint therapy has been successful some cases, many patients have not benefited enough due to primary/secondary resistance. In order optimize the therapeutic efficacy of anti-PD-L1 mAb, we used durvalumab as payload CUS245C , type I...
Aim: The aim is to study ANXA2 biomarkers for early diagnosis of cervical cancer. Materials & methods: used bioinformatics analysis and experimental verification expression in Results: was higher cancer tissues than non-cancer (p = 0.002). expressed cell membranes tissues, whereas it both the cytoplasm. Moreover, more pronounced squamous carcinomas. decreased overall survival patients, data suggested that protein associated with invasion migration tumors. Conclusion: has high specificity...
JOURNAL/nrgr/04.03/01300535-202511000-00034/figure1/v/2024-12-20T164640Z/r/image-tiff Previous studies have shown that the compound ( E )-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one (D30), a pyromeconic acid derivative, possesses antioxidant and anti-inflammatory properties, inhibits amyloid-β aggregation, alleviates scopolamine-induced cognitive impairment, similar to phase III clinical drug resveratrol. In this study, we established mouse model of Alzheimer’s disease via...