A5059187749- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Animal Behavior and Reproduction
- Ichthyology and Marine Biology
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- Material Properties and Applications
- Marine Biology and Environmental Chemistry
- melanin and skin pigmentation
- Fish Ecology and Management Studies
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Reproductive biology and impacts on aquatic species
- Photoreceptor and optogenetics research
- Fish biology, ecology, and behavior
- Aquaculture Nutrition and Growth
- Genomics and Chromatin Dynamics
University of Virginia
2018-2022
University of Washington
2014-2018
Seattle University
2014-2015
Vanderbilt University
2011-2013
Pigment patterns are useful for elucidating fundamental mechanisms of pattern formation and how these evolve. In zebrafish, several pigment cell classes interact to generate stripes, yet the developmental requirements origins cells remain poorly understood. Using zebrafish a related species, we identified roles thyroid hormone (TH) in development patterning, postembryonic more generally. We show that adult arise from distinct lineages having TH differential dependence can evolve within...
Changes in gene activity are essential for evolutionary diversification. Yet, elucidating the cellular behaviors that underlie modifications to adult form remains a profound challenge. We use neural crest-derived pigmentation of zebrafish and pearl danio uncover bases alternative pattern states. show stripes require novel class thin, fast projection promote Delta-Notch signaling over long distances from cells xanthophore lineage melanophores. Projections depended on microfilaments...
Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding genes and cell behaviors underlying evolution adult form. Among these species, zebrafish D. rerio several dark stripes melanophores with sparse iridophores alternate light interstripes dense xanthophores. By contrast, closely related species nigrofasciatus has an attenuated pattern fewer melanophores, interstripes. Here we demonstrate differences in iridophore development presage fully...
Understanding genetic and cellular bases of adult form remains a fundamental goal at the intersection developmental evolutionary biology. The skin pigment cells vertebrates, derived from embryonic neural crest, are useful system for elucidating mechanisms fate specification, pattern formation, how particular phenotypes impact organismal behavior ecology. In survey Danio fishes, including zebrafish rerio, we identified two populations white cells-leucophores-one which arises by...
Skin color patterns are ubiquitous in nature, impact social behavior, predator avoidance, and protection from ultraviolet irradiation. A leading model system for vertebrate skin patterning is the zebrafish; its alternating blue stripes yellow interstripes depend on light-reflecting cells called iridophores. It was suggested that zebrafish's pattern arises a single type of iridophore migrating differentially to interstripes. However, here we find iridophores do not migrate between but instead...
Abstract Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding genes and cell behaviors underlying evolution adult form. Among these species, zebrafish D. rerio several dark stripes melanophores with sparse iridophores alternate light interstripes dense xanthophores. By contrast, closely related species nigrofasciatus has an attenuated pattern fewer melanophores, interstripes. Here we demonstrate differences in iridophore development presage...
Understanding genetic and cellular bases of adult form remains a fundamental goal at the intersection developmental evolutionary biology. The skin pigment cells vertebrates, derived from embryonic neural crest, are useful system for elucidating mechanisms fate specification, pattern formation, how particular phenotypes impact organismal behavior ecology. In survey Danio fishes, including zebrafish rerio , we identified two populations white cells--leucophores--one which arises by...
Skin color patterns are ubiquitous in nature, evolve rapidly, and impact social behavior 1 , predator avoidance 2 protection from ultraviolet irradiation 3 . A leading model system for vertebrate skin patterning is the zebrafish 4-7 ; its alternating blue stripes yellow interstripes depend on guanine crystal-containing cells called iridophores that reflect light. It was suggested zebrafish’s pattern arises a single type of iridophore migrating differentially to 7-9 When we tracked...