A5009822694- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- Vascular Malformations Diagnosis and Treatment
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Biosensors and Analytical Detection
- Caveolin-1 and cellular processes
- Gut microbiota and health
- Mesenchymal stem cell research
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Intracerebral and Subarachnoid Hemorrhage Research
- Mast cells and histamine
- CAR-T cell therapy research
- COVID-19 diagnosis using AI
Sun Yat-sen University
2015-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2017-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Tianjin University
2024
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2024
National University of Singapore
2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Key Laboratory of Guangdong Province
2020-2021
Guangdong Province Special Equipment Testing and Research Institute Zhuhai Testing Institute
2017
Third Affiliated Hospital of Sun Yat-sen University
2008-2016
Treating COVID-19 with Chloroquine A novel coronavirus disease 2019 (COVID-19) emerged around December in Wuhan, China and has spread rapidly worldwide (Lu et al., 2020).Until March 27, 2020, the Chinese health authorities had reported 82082 confirmed cases 3298 deaths 381443 20787 outside China.The World Health Organization (WHO) named virus SARS-CoV-2, which belongs to a distinct clade from human severe acute respiratory syndrome CoV (SARS-CoV) Middle East (MERS-CoV) (Zhu 2020).At present,...
Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500 mg, orally, once (half dose) or twice (full...
Abstract Serological tests play an essential role in monitoring and combating the COVID-19 pandemic. Recombinant spike protein (S protein), especially S1 protein, is one of major reagents used for serological tests. However, high cost S production possible cross-reactivity with other human coronaviruses pose unavoidable challenges. By taking advantage a peptide microarray full coverage, we analyzed 2,434 sera from 858 patients, 63 asymptomatic patients 610 controls collected multiple...
Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), is associated with a loss or an imbalance of host-microorganism interactions. However, such interactions at protein levels remain largely unknown. Here, we applied depletion-assisted metaproteomics approach to obtain in-depth host-microbiome association networks IBD, where the core host proteins shifted from those maintaining mucosal homeostasis in controls involved inflammation, proteolysis, intestinal...
To investigate the survival benefit of transarterial chemoembolization (TACE) plus Iodine125 seed implantation (TACE-Iodine125) in hepatitis B-related HCC patients with portal vein tumour thrombus (PVTT) and underlying prognostic factors.A retrospective matched cohort study was performed on consecutive PVTT from January 2011 to June 2014. Seventy (TACE-Iodine125 group) who underwent TACE-Iodine125 were compared a historical case-matched control group 140 (TACE received TACE alone. The...
Abstract Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. Method multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500mg, orally, once...
RNA interference (RNAi) has significant therapeutic promise for the genetic treatment of hepatocellular carcinoma (HCC). Targeted vectors are able to deliver small interfering (siRNA) into HCC cells with high transfection efficiency and stability. The tripeptide arginine glycine aspartic acid (RGD)-modified non-viral vector, polyethylene glycol-grafted polyethylenimine functionalized superparamagnetic iron oxide nanoparticles (RGD-PEG-g-PEI-SPION), was constructed as a magnetic resonance...
Gastric varices (GVs) are a major cause of gastrointestinal bleeding in patients with portal hypertension. Few studies have evaluated GVs multidetector row computed tomography (MDCT).To assess the diagnostic performance MDCT detecting and revealing variceal hemodynamic changes cirrhosis.A total 127 consecutive cirrhotic who underwent both liver esophagogastroduodenoscopy (EGD) were analyzed retrospectively. Two independent radiologists reviewed images for detection GVs. The assessed by 2...
Our previous study showed that in vivo magnetic resonance (MR) imaging is effective tracking superparamagnetic iron oxide (SPIO)‐labeled bone marrow mesenchymal stem cells (BMSCs) rats with liver fibrosis. SPIO‐labeling‐induced signal reduction on MR images was completely reversed within 15 days after transplantation. It still unclear whether the changes could reflect number of transplanted liver. In present study, BMSCs male were doubly labeled enhanced green fluorescent protein (EGFP) and...
The neural ganglioside GD2 has recently been reported to be a novel surface marker that is only expressed on human bone marrow mesenchymal stem cells within normal marrow. In this study, an MRI-visible, targeted, non-viral vector for effective gene delivery was first synthesized by attaching targeting ligand, the single chain antibody (scAbGD2), distal ends of PEG-g-PEI-SPION. targeted then used condense plasmid DNA form nanoparticles showing stable small size, low cytotoxicity, and good...
Non-small cell lung cancer (NSCLC) is a leading cause of death, and metastasis crucial determinant increased mortality. DDX24 has garnered attention due to its correlation with tumorigenesis malignant progression. However, the between NSCLC remains unclear.DDX24 expression in tissues survival rate patients was analyzed using bioinformatic analysis. Transwell assays, wound-healing tail vein colonization models were employed determine role migration invasion vitro vivo. We searched for...
This study centers on the use of superparamagnetic iron oxide nanoparticles coated with polyethylene glycol-grafted polyethylenimine (PEG-g-PEI-SPION) as an MRI-visible and efficient nanovector for gene modification in vivo MRI tracking rat bone marrow-derived mesenchymal stem cells (rBMSCs). PEG-g-PEI-SPION was first condensed plasmid DNA to form nanoparticles, demonstrating low cytotoxicity good biocompatibility rBMSCs. Based a reporter assay, PEG-g-PEI-SPION/pDNA had highest transfection...
Endovenous microwave ablation (EMA) is a recently developed thermal technique used in the treatment of lower limb varicose veins. However, its efficacy and safety have been largely understudied. In present study, we sought to explore clinical results EMA radiofrequency (RFA) treating Patients who underwent (n = 65) or RFA 46) at our institute from September 2018 2020 were included this retrospective investigation. The complications evaluated 1, 3, 6, 12 months after procedure. effects on...
Accurate prediction of the risk progression coronavirus disease (COVID-19) is needed at time hospitalization. Logistic regression analyses are used to interrogate clinical and laboratory co-variates from every hospital admission an area 2 million people with sporadic cases. From a total 98 subjects, 3 were severe COVID-19 on admission. remaining 24 developed severe/critical symptoms. The predictive model includes four co-variates: age (>60 years; odds ratio [OR] = 12 [2.3, 62]); blood oxygen...
Vascular malformations present diagnostic and treatment challenges. In particular, of vessels to the viscera are often diagnosed late or incorrectly due insidious onset deep location disease. Therefore, a better knowledge genetic mutations underlying such diseases is needed. Here, we evaluated four‐generation family carrying vascular major that affect multiple organs, which named “multiorgan venous lymphatic defect” (MOVLD) syndrome. Genetic analyses identified an association between...
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel called severe acute respiratory syndrome 2 (SARS-CoV-2). spike protein (S) of SARS-CoV-2 major target for diagnosis and vaccine development because its essential role in viral infection host immunity. Currently, time-dependent responses humoral immune system against various S epitopes are poorly understood. In this study, enzyme-linked immunosorbent assay (ELISA), peptide microarray, antibody binding epitope mapping...
Human telomerase reverse transcriptase (hTERT) is highly expressed in many tumors and essential for tumorigenesis metastasis multiple cancers. However, the molecular mechanisms underlying its high expression level hepatocellular carcinoma (HCC) remain unclear. In this study, we identified X-ray repair cross-complementing 5 (XRCC5), a novel hTERT promoter-binding protein HCC cells, using biotin-streptavidin-agarose pull-down assay. We found that XRCC5 was which it transcriptionally...
Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and second leading cause cancer-associated mortality worldwide.Hepatitis C virus (HCV) infection primary hepatic fibrosis cirrhosis, which in turn, notably increase risk developing HCC.The systematic immune response plays a vital role protecting eukaryotic cells from exogenous antigens.In present study, to determine association between T miRNAs HCV-induced HCC (HCV-HCC), bulk mRNA miRNA sequencing data HCV-HCC tissues...