Since African swine fever virus (ASFV) replication is closely related to its host's machinery, codon usage of viral genome can be subject selection pressures. A better understanding give new insights into evolution. We implemented information entropy and revealed that the nucleotide pattern ASFV significantly associated with isolation factors (region time), especially usages thymine cytosine. Despite domination adenine in genome, we found mutation pressure alters overall ASFV, followed by...

Enterovirus A71 (EV-A71) is neurotropic and one of the primary enteric pathogens responsible for severe central nervous system infection in infants young children. Neonatal mice are ideal models studying pathogenesis caused by EV-A71. In this study, we assessed susceptibility neonatal BALB/c, C57BL/6, ICR, Kunming, NIH to a clinically isolated EV-A71 strain. One-day-old were challenged with clinical isolate via intraperitoneal injection, then observed 13 days mortality, body-weight changes,...

The inherent susceptibility to oxidation and poor sinterability significantly limit the practical application of Cu-based conductive inks. Most methodologies employed for inks like organic polymer coatings inorganic metal deposition are generally ineffective. Herein, we report design a novel hierarchical Cu architecture simultaneously improve antioxidative via self-passivation mechanism loose interior structures. was prepared using copper hydroxide, L-ascorbic acid, polyvinylpyrrolidone in...

Human telomerase reverse transcriptase (hTERT) is highly expressed in many tumors and essential for tumorigenesis metastasis multiple cancers. However, the molecular mechanisms underlying its high expression level hepatocellular carcinoma (HCC) remain unclear. In this study, we identified X-ray repair cross-complementing 5 (XRCC5), a novel hTERT promoter-binding protein HCC cells, using biotin-streptavidin-agarose pull-down assay. We found that XRCC5 was which it transcriptionally...

To identify the spectrum of RB1 gene mutations in 114 Chinese patients with retinoblastoma.Genomic DNA was extracted from peripheral blood Rb patients. Polymerase chain reactions (PCRs) followed by direct Sanger sequencing were used to screen for gene, which contains 26 exons flanking intronic sequences, except exon 15. Clinical data, including gender, age at diagnosis, laterality ocular lesions, and associated symptoms, recorded compared.We identified five novel gene. Twenty-five other...

The diffusion of new technology is an important driver agricultural development, especially in the developing world. In this research, we follow persistence major historical events, employing a difference‐in‐differences method to carefully examine long‐term effect China’s 1959–1961 famine on farm households’ current decisions adopt technology. Further, combine mediating regression procedure with bootstrap explore mechanism impact relationship. Overall, study provides strong empirical...

The nonstructural protein 5A (NS5A) of the bovine viral diarrhea virus (BVDV) is a monotopic membrane protein. This can anchor to cell by an in-plane amphipathic ⍺-helix, which participates in replication complex. In this study, effects synonymous codon usage pattern NS5A and overall transfer RNA (tRNA) abundance cells on formation were analyzed, based coding sequences different BVDV genotypes. represent most potential for genotyping. Moreover, nucleotide dominates genotype-specific usage....

Protein is fundamental to life, as it generates protein variants. The maintenance of a dynamic equilibrium in these variants, known homeostasis, crucial for cellular function. Various factors, both endogenous and exogenous, can disrupt homeostasis during synthesis. These factors include translational error, biological functions mediated by regulatory more. When cell accumulate proteins with folding errors, impairs leading the development related diseases. In response multiple monitoring...

This study estimates the impact of 1998 Great Flood on adoption agricultural technology in China and its mechanism using a cross-sectional dataset collected from ERA5-Land, Labor Force Dynamic Survey, Rural Statistical Yearbook, Population Census. The analysis reveals an inverted U-shaped correlation between farmers' exposure to flood event their propensity embrace technological advancements agriculture. Farmers who experienced medium tend be risk lovers exhibit 4.9% higher likelihood...

Abstract Working women's subjective well‐being has raised a growing interest and debate over the last few decades. The present study addresses puzzlement of whether gender ‘neutral’ or ‘matter’ in income‐happiness nexus by shedding new light on rice–wheat system. 9898 married female participants completed interview‐questionnaire from four waves Chinese General Social Survey 2012 to 2017, answering questions about well‐being, time allocation, role attitudes. We find different pattern...

Amidst the escalating loss of global biodiversity, freshwater mussels (family Unionidae) have become one most imperiled animal groups. Acquiring more biological and phylogenetic information on understudied taxa constitutes a pivotal aspect conservation biology. Consequently, comprehensive examination was conducted Koreosolenaia, Parvasolenaia, Sinosolenaia from China encompassing morphology, anatomy, distribution, molecular systematics to provide theoretical support for future species...

The influence of land tenure on agricultural investment has been widely discussed in developing countries, but the results existing studies are mixed. A data set from ancestral Leizhou Peninsula China that differentiates arrangements neighboring villages is used to explore determinants different types investments. Compared with contracted frequent reallocation owned by community, tenure, where farmers assert rights and enjoy long holdings, encourages private enhancing security also increases...

Identification of biomarkers to assist in the clinical management hepatocellular carcinoma represents an urgent requirement. Fibulin-2 is known contribute development and progression various cancer types. This research investigated role fibulin-2 explored possible mechanisms.The expression was measured by bioinformatic analysis confirmed western blot immunohistochemical staining cell lines or patients' samples. The clinicopathologic features patients analyzed. Cell viability assays were used...

Self-employment is a field of special importance to developing countries in view its positive role on socio-economic development. This study exploits unique nationally representative database using the 1949–1985 China Demographic Data, 2016 Labour Force Dynamic Survey, and 1959–1999 Drought Disaster Data. Through difference-in-differences estimation, we reveal that Great Chinese Famine bear significantly upon individuals' self-employment decisions. Specifically, 1% increase famine intensity...

Consider a bandit algorithm that recommends actions to self-interested users in recommendation system. The are free choose other and need be incentivized follow the algorithm's recommendations. While prefer exploit, can incentivize them explore by leveraging information collected from previous users. All published work on this problem, known as exploration, focuses small, unstructured action sets mainly targets case when users' beliefs independent across actions. However, realistic...

China aims to utilize the futures market stabilize agricultural product price fluctuation by quantifying effects of risk transfer and discovery. However, role futurization has been questioned even posited as cause drastic fluctuations in spot prices. This research clarify impact on products provide policy reference for development through research. Here, we examine data apples use Interrupted time-series analysis (ITSA) GARCH models estimate apple volatility Our findings demonstrate that...

The preference for sons transcends many cultures, making it an issue with local and global dimensions. This article explores if how married women’s preferences in relation to their children are influenced by a shift economic status. Our results show that female employment had significant effect on son preference. Specifically, participation the labour market reduces 15.7 per cent, 10 cent increase wages leads further 0.05 reduction having rather than daughters. also support view factors...

Background & Aims: Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction and in severe cases, even life-threatening. In the past few decades, risk factors related to BCS, including inherited acquired hypercoagulable states or other predisposing factors, have been reported. However, a large number of patients no identifiable etiological factors. And, there are different causes for BCS West East. China, segmental membranous inferior vena cava main manifestation BCS....