A5101972223- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- RNA and protein synthesis mechanisms
- Sports injuries and prevention
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Advanced oxidation water treatment
- Water Treatment and Disinfection
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Machine Learning in Bioinformatics
- Environmental Chemistry and Analysis
- Extracellular vesicles in disease
- Acute Lymphoblastic Leukemia research
- Behavioral Health and Interventions
- Protease and Inhibitor Mechanisms
- Kruppel-like factors research
- Environmental remediation with nanomaterials
- Cancer Cells and Metastasis
Sun Yat-sen University
2015-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2017-2024
Second Military Medical University
2017-2024
Changhai Hospital
2017-2024
Chinese Academy of Agricultural Sciences
2023-2024
Jiamusi University
2023
Ministry of Agriculture and Rural Affairs
2023
Huaqiao University
2023
Tobacco Research Institute
2023
State Key Laboratory of Oncology in South China
2014-2021
Abstract Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Elucidating underlying mechanisms this disease could provide new therapeutic strategies for treating HCC. Here, we identified a novel role DEAD-box helicase 24 (DDX24), member protein family, in promoting HCC progression. DDX24 levels were significantly elevated tissues and associated with poor prognosis Overexpression promoted migration proliferation vitro vivo, whereas suppression inhibited both functions....
The aim of this study was to explore the expression and clinical significance miR-494 PTEN (phosphatase tensin homologue deleted on chromosome ten) in non-small cell lung cancer (NSCLC). Immunohistochemistry for situ hybridization (ISH) were performed 92 NSCLC tissues 10 normal detect their expression, correlation between with characteristics prognosis analyzed. significantly higher than (P = 0.004). positive protein carcinoma lower that 0.013), while level negatively correlated (r -0.577, P...
The aim of our study was to assess the medium-term clinical outcomes anterior cruciate ligament (ACL) reconstruction using Ligament Advanced Reinforcement System (LARS) artificial ligament. A total 168 patients who underwent arthroscopic ACL with LARS in department were enrolled research. Only 125 met inclusion/exclusion criteria, and 91 could ultimately be contacted participate mean follow-up 92 ± 19 months. Physical examinations a KT-1000 arthrometer used evaluate knee laxity....
Nuclear receptor coactivator 3 (NCOA3) is a transcriptional that has elevated expression in multiple tumor types, including colorectal cancer (CRC). However, the molecular mechanisms regulate tumorigenic functions of NCOA3 CRC remain largely unknown. In this study, we aimed to discover and identify novel regulatory proteins explore their action. Immunoprecipitation (IP) coupled with mass spectrometry (IP-MS) analysis was used detect, identify, verify interacted cells. The biological...
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted growth of human melanoma cells. knockdown significantly inhibited cell viability migration induced apoptosis, whereas overexpression effectively proliferation in various lines. Further study showed that regulated by targeting hTERT-dependent signal pathway. Knockdown markedly...
// Wenxian Hu 1, * , Yunlu Jia Xiangsheng Xiao 2 Kezhen Lv 3 Yongxia Chen 1 Linbo Wang Luo Tianze Liu Wenbin Li Yixin Changlin Zhang Zhenglong Yu 4 Wenlin Huang 2, 5 Bing Sun Wu-guo Deng Department of Surgical Oncology, Sir Run Shaw Hospital, College Medicine, Zhejiang University, Hangzhou, China Yat-Sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Guangzhou, Breast The First Affiliated Thoracic Surgery, Hospital Dalian Medical...
Limb salvage reconstruction for pelvic tumors, especially periacetabular is challenging. We combined the use of dual mobility bearing and 3D-printed hemipelvic prosthesis to improve function reduce probability complications after hemi-pelvic resection in patients with primary acetabular malignancy. The purpose this study was evaluate efficacy safety combination.Between October 2011 May 2021, 11 malignancies involving acetabulum received replacement a bearing. Follow-up postoperative...
// Yun Tian 1, * , Lijun Qin 3, Huijuan Qiu Dingbo Shi 1 Rui Sun Wenbing Li Tianze Liu Jingshu Wang Tingting Xu 4 Wei Guo Tiebang Kang Wenlin Huang 5 Guowen 2, Wuguo Deng 5, Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China 2 Department Bone and Soft Tissue Tumors, Tianjin Medical Institute Hospital, National Clinical Research for Cancer, Prevention Therapy, Tianjin, 3 Pediatrics, Memorial University,...
Activation of the telomere maintenance mechanism is a key hallmark cancer. Human telomerase reverse transcriptase (hTERT) catalytic subunit telomerase, which highly expressed in more than 80% tumors, including hepatocellular carcinoma (HCC). However, exact mechanisms by hTERT up-regulated HCCs and promotes tumor growth progression not fully understood. The aim this study was to discover novel molecular targets that modulate signaling HCC growth. In study, we pulled down identified RBFOX3...
BACKGROUND Osteoarthritis (OA) affects about 40% of people older than 40 years age, and the mechanism is not well understood. Long non-coding RNA (lncRNA) CAIF a recently identified critical player in myocardial infarction, while its role other human diseases unclear. The present study aimed to investigate OA. MATERIAL AND METHODS Levels synovial fluid OA patients (n=60) healthy controls were measuring by performing quantitative real-time polymerase chain reaction (qRT-PCR). MiR-1246...
Although progress has been made in the treatment of LAUD, survival rate for patients remains poor. An in-depth grasp molecular pathways implicated LUAD progression is vital improving diagnosis and strategies. This study aims to explore novel mechanisms driving identify new potential prognostic biomarkers LAUD patients.
Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting 6024 genes identified as potential therapeutic target melanoma cells. Knockdown significantly suppressed cell proliferation induced apoptosis, well enhanced antitumor effect melatonin vitro vivo. Overexpression Ku80, however, promoted increased insensitivity cells to...
Drug dependence causes an overestimation of drug-related stimuli and underestimation non-drug-related stimuli, such as food. The purpose this study was to investigate the effects acute moderate-intensity dance aerobic exercise on drug craving, appetite, prefrontal neural activation food cues, reward in women with methamphetamine MA dependence.Thirty-nine who met Diagnostic Statistical Manual Mental Disorders, Fifth Edition criteria participated experiment were randomly assigned either a (n =...
RBFOX3, an RNA-binding fox protein, plays important role in the differentiation of neuronal development, but its chemosensitivity hepatocellular carcinoma (HCC) to 5-FU is unknown.In this study, we examined biological functions RBFOX3 and effect on HCC cells vitro a mouse xenograft model.RBFOX3 was found have elevated expression cell lines tissue samples, knockdown inhibited proliferation. Moreover, improved inhibitory 5-fluorouracil (5-FU) proliferation, migration invasion, enhanced...
Cervical cancer is an aggressive cutaneous malignancy, illuminating the molecular mechanisms of tumorigenesis and discovering novel therapeutic targets are urgently needed.KMT2A a transcriptional co-activator regulating gene expression during early development hematopoiesis, but role KMT2A in cervical remains unknown.Here, we demonstrated that regulated growth via targeting VADC1.Knockdown significantly suppressed cell proliferation migration induced apoptosis cells, accompanying with...
// Dingbo Shi 1,* , Xiangsheng Xiao Yun Tian Lijun Qin 3 Fangyun Xie 1 Rui Sun Jingshu Wang Wenbin Li Tianze Liu Yao 2 Wendan Yu Wei Guo Yuqing Xiong Huijuan Qiu Tiebang Kang Wenlin Huang 1,4 Chong Zhao and Wuguo Deng Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China Institute Stem Cell, Dalian Medical University, Dalian, Department Pediatrics, Memorial Hospital, 4 Targeted Drug for Tumors Guangdong...
Recent Clinical trials of administration epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival patients advanced NSCLC, However, the sequential treatment EGFR-TKIs and is expected NSCLC. The aim this study test antiproliferative effect pemetrexed combined icotinib different sequences on non-small cell lung cancer (NSCLC) lines determine optimal schedule, subsequently elaborated potential...
OBJECT This study sought to make a biomechanical comparison of 3 different posterior fixation techniques for 2-level lumbar spinal disorders. METHODS Eight fresh-frozen human cadaver spines (4 from L-1 L-5, 4 S-1) were tested by applying pure moments ± 8 Nm. Each specimen was first intact, and then the left facetectomies L3–4 L4–5 performed establish an unstable condition without removal discs. Three instrumentation systems randomly: unilateral pedicle screw (UPS), UPS with contralateral...