A5020090228- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Plant Molecular Biology Research
- Plant Disease Resistance and Genetics
- Cancer-related molecular mechanisms research
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- RNA modifications and cancer
- Higher Education and Teaching Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Traditional Chinese Medicine Studies
- Fungal and yeast genetics research
- Geomechanics and Mining Engineering
- Medical Research and Treatments
- Pregnancy and preeclampsia studies
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
Fourth Hospital of Changsha
2025
Harbin Institute of Technology
2015-2024
Nanjing University
2014-2024
Minhang District Central Hospital
2013-2023
Fudan University
2018-2023
Jiangsu University
2015-2023
Sun Yat-sen University
2023
Southern Medical University
2023
Nanfang Hospital
2023
Heilongjiang Institute of Technology
2023
All eukaryotic cells divide a finite number of times, although the mechanistic basis this replicative aging remains unclear. Replicative is accompanied by reduction in histone protein levels, and cause budding yeast. Here we show that nucleosome occupancy decreased 50% across whole genome during using spike-in controlled micrococcal nuclease digestion followed sequencing. Furthermore, nucleosomes became less well positioned or moved to sequences predicted better accommodate octamers. The...
Genome-wide analyses of changes in gene expression, transcription factor occupancy on DNA, histone modification patterns chromatin, genomic copy number variation, and nucleosome positioning have become popular many modern laboratories, yielding a wealth information during health disease states. However, most these studies overlooked an inherent normalization problem that must be corrected with spike-in controls. Here we describe the reason why controls are so important explain how to...
Translational efficiency correlates with longevity, yet its role in lifespan determination remains unclear. Using ribosome profiling, translation is globally reduced during replicative aging budding yeast by at least two mechanisms: Firstly, Ssd1 induced aging, sequestering mRNAs to P-bodies. Furthermore, overexpression young cells and extended lifespan, while loss of the translational deficit old shortened lifespan. Secondly, phosphorylation eIF2α, mediated stress kinase Gcn2, was elevated...
Abstract Hierarchical carbon nanocages as emerging nanomaterials have a great potential for photothermal therapy due to their unique porous structure, high specific surface area, and excellent property. Herein, hierarchical nitrogen‐doped nanocage (hNCNC) is introduced second near‐infrared agent, then functionalizes it with metal‐organic hydrogel (MOG) form thermal‐responsive switch sensitized therapy. Upon 1064 nm light irradiation, the hNCNCs exhibit remarkable conversion efficiency of...
MicroRNAs may function to promote or suppress tumor development, depending on the cellular context. The important role of microRNAs in regulating molecular pathways underlying tumorigenesis has been emphasized hepatocellular carcinoma (HCC). regulate gene expression via post-transcriptional mechanisms by inhibiting translation degrading mRNA. In this study, we show that microRNA-1 (miR-1) and microRNA-499 (miR-499) are capable repressing ets1 proto-oncogene, which plays a fundamental...
Photodynamic therapy (PDT) is a non-invasive with many advantages over other therapeutic methods, but it restricted to treat superficial cancers due the shallow tissue penetration of visible light. The biological window in near infrared region (NIR) offers hope extend depth, there no natural NIR excited photosensitizer. Here, we report novel photosensitizer: NaYbF4 nanoparticles (NPs). By using 1,3-diphenylisobenzofuran (DPBF) sensor, show that Yb3+ ions can absorb light and transfer energy...
Abstract Although mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, their efficacy reliable lineage markers is hindered by the complex dynamics of mtDNA in somatic tissues. Here, we utilized computational modeling and single-cell genomics to thoroughly interrogate origin clonal across various biological settings. Our findings revealed majority purported “clone informative (CIVs)” were pre-existing heteroplamies first instead de novo...
Diamond holds significant promise for a wide range of applications due to its exceptional physicochemical properties. Investigating the controlled diamond preparation from nanocarbon precursors with varying dimensions is crucial optimize transition conditions and even elucidate daunting transformation mechanism, however, this remains outstanding challenge despite considerable effort. Herein, we report imperative dimension effect on synthesis physical mechanism under high temperature...
Hepatocellular carcinoma (HCC) accounts for 75% of liver cancers and is the second most lethal cancer, associated with its multiple etiologies, poor prognosis resistance to chemotherapy drugs. Chemotherapy treatment on HCC suffers low efficacy drug uptake can produce a range side effects. Here we report an investigation effect combined human hepatocellular BEL-7402 cells using low-intensity ultrasound (US) 5-fluorouracil (5-FU). The 5-FU was measured by high-performance liquid chromatography...
Objective Sonodynamic therapy (SDT) is promising for treatment of cancer, but its effect on osteosarcoma unclear. This study examined the 5-Aminolevulinic Acid (5-ALA)-based SDT growth implanted and their potential mechanisms in vivo vitro. Methods The dose metabolism 5-ALA ultrasound periods were optimized a mouse model induced UMR-106 cells. effects ALA-SDT proliferation apoptosis cells examined. levels mitochondrial membrane (ΔψM), ROS production, BcL-2, Bax, p53 caspase 3 expression...
Abstract Invited for the cover of this issue is group Qiang Wu and Zheng Hu at Nanjing University. The image depicts sulfur nitrogen codoped carbon tubes as bifunctional metal‐free electrocatalysts oxygen reduction hydrogen evolution in acidic media. Read full text article 10.1002/chem.201601535 .
// Lili Pan 1, 2, * , Yang Li Hai-Ying Zhang 2 Yi Zheng Xiao-Li Liu Hu Wang 3 Jing Yuan-Hua Cai Qiao Wan-Ling Chen Ying Guo Yuan-Mao Huang Feng Qian Jin Jiucun and Shao-Yuan 1 Fujian Institute of Hematology, Provincial Key Laboratory on Department Medical University Union Hospital, Fuzhou, PR China Clinical Colleges, University, State Genetic Engineering Ministry Education Contemporary Anthropology, School Life Sciences, Fudan Shanghai, These authors have contributed equally to this work...
Abstract Background & Aims Several studies have shown that miR‐320a induces apoptosis, inhibits cell proliferation, and affects cycle progression as a tumour suppressor in many cancers. However, the involvement of invasion metastasis hepatocellular carcinoma ( HCC ) is still unknown. Methods Endogenous high mobility group box 1 HMGB 1) expressions were assayed by real‐time PCR . Luciferase activities measured using dual‐luciferase reporter assay system. Western blots used to determine...