A5073657733- MicroRNA in disease regulation
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Neurobiology and Insect Physiology Research
- Extracellular vesicles in disease
Sun Yat-sen University
2018-2021
Fifth Affiliated Hospital of Sun Yat-sen University
2018-2021
Myocardial infarction (MI) is a severe cardiovascular disease. Some M1 macrophage‐derived extracellular vesicles (EVs) are involved in the inhibition of angiogenesis and acceleration dysfunction during MI. However, potential mechanism phenotype bone marrow‐derived macrophages‐ (BMMs‐) EVs (M1‐BMMs‐EVs) MI largely unknown. This study sought to investigate whether M1‐BMMs‐EVs increased CDC42 expression activated MEK/ERK pathway by carrying lncRNA MALAT1 competitively binding miR‐25‐3p, thus...
Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting 6024 genes identified as potential therapeutic target melanoma cells. Knockdown significantly suppressed cell proliferation induced apoptosis, well enhanced antitumor effect melatonin vitro vivo. Overexpression Ku80, however, promoted increased insensitivity cells to...