A5013442403- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Polymer Surface Interaction Studies
- Polydiacetylene-based materials and applications
- Surfactants and Colloidal Systems
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Plant Surface Properties and Treatments
- Advanced Polymer Synthesis and Characterization
- Chemical Synthesis and Analysis
- Molecular Junctions and Nanostructures
- Pesticide and Herbicide Environmental Studies
- Protein purification and stability
- Probiotics and Fermented Foods
- Block Copolymer Self-Assembly
- Analytical Chemistry and Chromatography
- Biochemical and Structural Characterization
- Environmental Chemistry and Analysis
- Supercapacitor Materials and Fabrication
- Dendrimers and Hyperbranched Polymers
- Neuropeptides and Animal Physiology
- Polymer-Based Agricultural Enhancements
- COVID-19 and healthcare impacts
- Aerogels and thermal insulation
University of Manchester
2019-2025
South China University of Technology
2017-2020
Green Chemistry
2017
Harbin Engineering University
2016
AT&T (United States)
1985
Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and outer (OM). Antimicrobial peptides (AMPs) must first permeate through the OM cell wall before attacking IM to cause leakage kill bacteria. The bacterial is asymmetric bilayer with leaflet primarily composed of lipopolysaccharides (LPSs) phospholipids (PLs). Two cationic α-helical AMPs were designed target bacteria, a full peptide G(IIKK)3I-NH2 (G3), hydrophobic lipopeptide C8-G(IIKK)2I-NH2 (C8G2, C8 denoting...
It is widely regarded that antimicrobial peptides (AMPs) kill bacteria by physically disrupting microbial membranes and causing cytoplasmic leakage, but it remains unclear how AMPs disrupt the outer membrane (OM) of Gram-negative (GNB) then compromise inner membrane. We hypothesise different impose structural disruptions, with direct implications to their efficacies. The activities three typical AMPs, including designed short AMP, G3, two natural melittin LL37, against E. coli haemolytic...
can cause various gastric conditions including stomach cancer in an acidic environment. Although early
Molecular dynamics (MD) simulations, stochastic optical reconstruction microscopy (STORM), and neutron reflection (NR) were combined to explore how antimicrobial peptides (AMPs) can be designed promote the formation of nanoaggregates in bacterial membranes impose effective bactericidal actions. Changes hydrophobicity AMPs found have a strong influence on their potency cytotoxicity. G(IIKK)3I-NH2 (G3) achieved low minimum inhibition concentrations (MICs) dynamic kills against both...
Antimicrobial peptides are promising alternatives to traditional antibiotics. A group of self-assembling lipopeptides was formed by attaching an acyl chain the N-terminus α-helix-forming with sequence Cx-G(IIKK)yI-NH2 (CxGy, x = 4–12 and y 2). CxGy self-assemble into nanofibers above their critical aggregation concentrations (CACs). With increasing x, CACs decrease hydrophobic interactions increase, promoting secondary structure transitions within nanofibers. activity, determined minimum...
Epidemics such as pulmonary tuberculosis and pertussis can spread quickly through the air in enclosed or small spaces. Most of these diseases are caused by various bacteria. In hospitals, nursing homes, biology laboratories, requirement for quality is often high. Particulate filters remove infectious bacteria from air, making them a good choice local ventilation systems to capture other pathogenic microbes. With high surface area, electrospun poly(l-lactic acid) (PLLA) fibrous membranes have...
Abstract The formation of dendrites associated with corrosion reactions undermines the cycling stability aqueous zinc‐ion batteries (AZBs). Despite extensive efforts, conventional strategies, e.g., electrolyte modification, and artificial protection layers, often suffer from low stability. Inspired by cell membranes, a series phospholipid analogues C n P m is designed which can spontaneously adsorb onto Zn electrode to form bimolecular protective layer. By tuning head length or tail lipid...
Molecular dynamics simulations are conducted to investigate the underwater oleophobicity of self-assembled monolayers (SAMs) with different head groups. Simulation results show that order SAMs is methyl < amide oligo(ethylene glycol) (OEG) ethanolamine (ETA) hydroxyl mixed-charged zwitterionic. The underwater–oil contact angles (OCAs) <133° for all nonionic hydrophilic SAMs, while zwitterionic superoleophobic (OCA can reach 180°). It appears surfaces stronger have better antifouling...
A facile one‐step hydrothermal strategy has been developed to prepare 3D porous Co 3 O 4 /graphene aerogel (Co /GA). Due the combination of a highly interconnected network GA and nanospheres, resulting /GA electrode exhibits exceptional electrical conductivity pseudocapacitance, making it an excellent material for energy‐storage devices. The composites possess high specific surface area 127 m 2 g –1 broad pore‐size distribution 1–110 nm. presence is found be remarkably effective in enhancing...
Abstract Recent developments in antimicrobial peptides (AMPs) have focused on the rational design of short sequences with less than 20 amino acids due to their relatively low synthesis costs and ease correlation structure‐function relationship. However, gaps remain understanding how cationic AMPs interact bacterial outer inner membranes affect efficacy dynamic killing. The membrane‐lytic actions two designed AMPs, G(IIKK) 3 I‐NH 2 (G ) 4 ), previously‐studied controls GLLDLLKLLLKAAG‐NH...
Cationic biocides have been widely used as active ingredients in personal care and healthcare products for infection control wound treatment a long time, but there are concerns over their cytotoxicity antimicrobial resistance. Designed lipopeptides potential candidates alleviating these issues because of mildness to mammalian host cells high efficacy against pathogenic microbial membranes. In this study, cytotoxic properties de novo designed lipopeptide,...
Surfaces with controlled oil wettability in water have great potential for numerous underwater applications. In this work, we proposed two schemes, alkyl chain length dependent and ionic strength dependent, to achieve controllable oelophobic surfaces. The oil-resistant property of the obtained self-assembled monolayers (SAMs) was evaluated by using an droplet (1,2-dichloroethane) as a detecting probe. oleophobicity SAM surfaces could be modulated from superoleophilic (contact angle ca. 0°)...
The formation of channel membrane polystyrene‐ block ‐poly(4‐vinyl pyridine) copolymer is studied by computer simulations with the nonsolvent induced phase separation (SNIPS) method. Dissipative particle dynamics employed to study microphase process and SNIPS mechanism. Simulation results indicate that polymer concentration has a significant effect on structure. Channel membranes form in range 44–58%. Block ratio plays an important role shaping Solvent exchange rate also affects degree at...
Understanding the interaction mechanism between catechol-cation and inorganic surfaces is vital for controlling interfacial adhesion behavior. In this work, molecular dynamics simulations are employed to study of siderophore analogues (Tren-Lys-Cam, Tren-Arg-Cam Tren-His-Cam) on silica with different degrees ionization effects cationic amino acids ionic strength discussed. Simulation results indicate that onto ionized surface dominated by electrostatic interactions. At ionization, rank...
Understanding the interactions between aromatic compounds and organic surfaces is vital for adhesion applications. In this work, molecular dynamics simulations are employed to study of substituted on graphene hydroxylated surfaces. Effects substituent groups, number position hydroxyl layers adsorbate concentration discussed. Simulation results indicate that both electron-donating electron-withdrawing benzene ring could enhance graphene, groups have a strong effect ring's adsorption graphene....
The antifouling property of exogenous materials is vital for their in vivo applications. In this work, dissipative particle dynamics simulations are performed to study the self-assembled morphologies two copolymer systems containing poly(ethylene glycol) (PEG) and poly(carboxybetaine) (PCB) aqueous solutions. Effects polymer composition concentration on structures copolymers (PLA-PEG PLA-PCB) investigated, respectively [PLA represents poly(lactic acid)]. Results show that whatever is,...
Abstract Zwitterionic materials have attracted increasing attentions in the underwater super‐oleophobic applications for its strong hydration via electrostatic interactions. Herein, molecular dynamics simulations were used to investigate and oleophobicity of sulfobetaine‐terminated self‐assembled monolayers (SB‐SAMs) with different carbon spacer lengths (CSL) between oppositely charged groups SB molecules. Simulation results show that SB‐SAMs is positively dependent on CSL; strengthened then...