A5101915987- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Cervical and Thoracic Myelopathy
- Spinal Cord Injury Research
- Bone Tissue Engineering Materials
- Sarcoma Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Analysis
- Cancer-related molecular mechanisms research
- Trauma Management and Diagnosis
- MicroRNA in disease regulation
- Spinal Hematomas and Complications
- Shoulder and Clavicle Injuries
- Nerve injury and regeneration
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Aortic Disease and Treatment Approaches
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Tendon Structure and Treatment
- Land Use and Ecosystem Services
- Scoliosis diagnosis and treatment
- Urban Agriculture and Sustainability
Jilin University
2015-2023
Union Hospital
2018-2023
New York University
2023
Chinese Academy of Sciences
2022
Changchun Institute of Applied Chemistry
2022
Xuzhou Medical College
2022
Second People’s Hospital of Huai’an
2022
Second Affiliated Hospital of Jilin University
2020-2022
Suzhou Traditional Chinese Medicine Hospital
2022
Nanjing University of Chinese Medicine
2021
Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)-mediated neurovascular unit formation. However, effects of central nerve system-derived MECs on neovascularization and neurogenesis, potential signaling involved therein, are unclear. Here, we established a primary cord-derived (SCMECs) isolation with high yield purity describe differences brain-derived (BMECs) their therapeutic SCI. Transcriptomics proteomics revealed...
Bone Repair In article number 2202044, Jiayong Dai, Jianxun Ding, Huanghao Yang, and co-workers develop an osteoimmunity-regulating biomimetically hierarchical scaffold to improve large-scale bone-defect regene ration through alleviating inflammation, enhancing neovascularization, stimulating osteogenesis, inhibiting osteoclasts, facilitating the balance of immune system bone metabolism augmenting repair.
The treatment of tendon/ligament-to-bone injury is a long-standing research challenge in orthopedics and bone tissue engineering. Orderly healing the fibrocartilage layer mineralized crucial for treating tendon-bone interface injuries. We designed three-dimensional printed porous titanium scaffold composite system with thermosensitive collagen hydrogel loaded transforming growth factor β3 (TGF-β3), formulated sustained slow release TGF-β3 at constant rate. In vitro, exhibited good...
The purpose of this research is to assess the feasibility poly(lactic-co-glycolic) acid (PLGA) incorporating gelatin microspheres (PLGA/GMs scaffold) for enhancing osteogenesis in vitro and at a radius defect rabbits after X-ray radiation vivo. After microspheres, PLGA scaffold demonstrated improved mechanical properties. Moreover, sustained release property recombinant human bone morphogenetic protein-2 (BMP-2) was achieved BMP-2-releasing PLGA/GMs scaffold. also enhanced proliferation...
Osteosarcoma (OS) is the most common primary bone malignancy derived from primitive bone-forming mesenchymal cells. Long noncoding RNA (lncRNA) expression profiles have been intensively studied for their involvement in OS. Herein, we clarify whether lncRNA CEBPA-AS1 a regulator of NCOR2 OS Microarray-based analysis identified OS-related differentially expressed and predicted microRNAs (miRs) binding to mRNA. were found be weakly tissues Next, functional investigation revealed that lncRNAs...
The development of effective treatment for the infection and bone defect resulting from advanced osteomyelitis is an urgent task in orthopedic clinic. To simultaneously address issues defect, multifunctional electrospun scaffolds composed polylactide (PLA), nano-hydroxyapatite-graft-polylactide (nHA-g-PLA), antibiotic vancomycin (VAN) were developed present study. composite PLA/nHA/VAN could sustainably release VAN exhibited excellent antibacterial activity toward S. aureus. rough surface...
Abstract During the human bone formation, event of osteogenic differentiation mesenchymal stem cells (hBMSCs) is vital, and recent evidence has emphasized important role microRNAs (miRNAs) in hBMSCs. This study aims to examine potential effects miR‐200c hBMSCs understand their underlying mechanisms. HBMSCs were obtained via marrow. induction differentiation, transfected with different plasmids intention investigating roles on calcium salt deposition, alkaline‐phosphatase (ALP) activity,...
The overarching goal of our research was to compare the clinical and radiological outcomes with different sizes cages implantation in anterior cervical discectomy fusion (ACDF), evaluate effects on surgical adjacent segmental intervertebral foramina.The data 61 patients were analyzed retrospectively. included disk space height before (H0) after surgery (H), preoperative mean segments (Hm), area segment foramen, Cobb angle (α1), C2-7Cobb (α2). calculation conducted by Japanese Orthopaedic...
Abstract Background Osteosarcoma (OS) is the most frequent primary malignancy of bone with a high incidence in adolescence. This study aimed to construct publicly available, integrated database human OS, named HOsDb. Methods Microarray data, current databases, and literature search PubMed were used extract information relevant OS-related genes their transcription factors (TFs) single nucleotide polymorphisms (SNPs), as well methylation sites microRNAs (miRNAs). was collated for constructing...
As an irreplaceable ecological barrier, conservation developing area (ECDA) is vital for the integrated construction of urban and rural areas optimization adjustment industrial structures. However, few empirical studies have been conducted on spatiotemporal variations agricultural green development (AGD) in ECDAs large cities. Based traits Beijing accessible data, we evaluated AGD analyzed its spatial temporal heterogeneity Beijing’s by constructing a framework with 13 indicators. The...
The aim was to explore the effect of lateral recess decompression by percutaneous transforaminal endoscopic spine system (Tessys) technique combined with discectomy (PTED) on pain medium, nerve function and stress response in patients suffering from contralateral symptoms lumbar disc herniation. A total 96 herniation treated our hospital February 2015 April 2017 were randomly divided into control group study group, 48 cases each group. underwent PTED, Tessys PTED. visual analogue scale (VSA)...
According to 73 patients with middle clavicle fracture treated conservatively, a new classification of was proposed, and the clinical effect plastic splint in treatment observed.Total from September 2018 August 2020 were analyzed retrospectively. All divided into 4 types according degree displacement. There 16 cases typeⅠ, including 7 males 9 females, ranging age 18 37 years old, mean (28.6±7.8) old;12 mild disease, 3 moderate disease 1 case severe disease. type Ⅱ, 6 10 25 49 (37.3±9.4)...
Spinal cord injury (SCI) is still a difficult problem because of its complex pathophysiology. Stem cell transplantation are considered as the most promising treatment for SCI due to their nerve regeneration and neuroprotective effect. The methods human umbilical mesenchymal stem (HUC-MSC) culture differentiation have been improved. Moreover, mechanism neural repair has preliminarily clarified. Combination therapy other comprehensive improved effect transplantation. In addition, several...
Abstract 2-(2-benzofu-ranyl)-2-imidazoline (2-BFI) is a drug that has attracted much attention in recent years. It therapeutic effect on brain diseases such as Alzheimer’s disease and cerebral infarction. However, whether 2-BFI affects the proliferation of cells exposed to fluoride not known. We investigated apoptosis SH-SY5Y fluoride, was used protect against effects fluoride. found could enhance upon fluorosis by maintaining stability endoplasmic reticulum–mitochondria contact sites...
Abstract Background : On the basis of conservative treatment 81 midshaft clavicle fractures, a new type fracture was proposed and clinical effect plastic splinting in these fractures observed. Methods Eighty-one patients with treated splints from January 2018 to July 2020 were retrospectively analyzed. The divided into four types according their displacement. All underwent splint fixation for 4 weeks. visual analog scale score, Constant–Murley shoulder joint patient satisfaction...