A5038975486- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Silk-based biomaterials and applications
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Musculoskeletal synovial abnormalities and treatments
- Reconstructive Surgery and Microvascular Techniques
- Advanced Glycation End Products research
- Collagen: Extraction and Characterization
- Bone Tumor Diagnosis and Treatments
- Titanium Alloys Microstructure and Properties
- Spinal Cord Injury Research
- Bone Metabolism and Diseases
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Nerve injury and regeneration
- Peroxisome Proliferator-Activated Receptors
Second Affiliated Hospital of Jilin University
2004-2025
Jilin University
2014-2024
First Hospital of Jilin University
2017
In recent years, there has been increasing interest in using biomimetic materials for bone tissue engineering. However, the high immunogenicity and low mechanical properties of limit their applications vivo. As an essential component extracellular matrix tissue, collagen is ideal because it easily degrades strong plasticity immunogenicity. pure alone does not yield satisfactory experimental results. Therefore, engineering scaffolds are often prepared together with other bioactive to better...
Abstract Objective This study aims to investigate the effects of a quadriceps isometric contraction exercise method in treatment knee osteoarthritis ( OA ). Methods A total 250 patients with confirmed diagnosis were enrolled. The randomly divided into an test group (128 patients) and traditional control (122 patients). Quadriceps was used group, local physiotherapy oral nonsteroidal anti‐inflammatory drugs group. Knee joint function evaluated visual analog scale VAS ) score Western Ontario...
The treatment of tendon/ligament-to-bone injury is a long-standing research challenge in orthopedics and bone tissue engineering. Orderly healing the fibrocartilage layer mineralized crucial for treating tendon-bone interface injuries. We designed three-dimensional printed porous titanium scaffold composite system with thermosensitive collagen hydrogel loaded transforming growth factor β3 (TGF-β3), formulated sustained slow release TGF-β3 at constant rate. In vitro, exhibited good...
Recombinant human-like collagen (RHLC) was blended with fibroin to prepare a novel biocompatible film as scaffold material for hepatic tissue engineering applications. Solution blending used incorporate RHLC silk enhance the blend films biocompatibility and hydrophilicity while maintaining elasticity. FTIR XRD analysis indicated that hydrogen bonds had formed between RHLC, SEM microscopy data confirmed homogeneous microstructures were still retained after introduction of fibroin. Contact...
BACKGROUND:We explored the application of 3-dimensional (3D) printing technology in treating giant cell tumors (GCT) proximal tibia. A tibia block was designed and produced through 3D technology. We expected that this 3D-printed would fill bone defect after en-bloc resection. Importantly, block, combined with a standard knee joint prosthesis, provided attachments for collateral ligaments knee, which can maintain stability. MATERIAL AND METHODS:A computed tomography (CT) scan taken both...
Tumor resection and treatment of trauma-related regional large bone defects have major challenges in the field orthopedics. Scaffolds that treat are focus tissue engineering. 3D printing porous titanium alloy scaffolds, prepared via electron beam melting technology, possess customized structure strength. The addition a growth factor coating to scaffold introduces specific form biological activation. Vascular endothelial (VEGF) is key angiogenesis osteogenesis vivo . We designed...
The repair of severe bone defects is a great challenge in orthopedics. Although autologous grafting remains the gold standard for treatment defects, trauma, infection, and other problems associated with this procedure have limited its use clinical practice. Three-dimensional (3D) printing technology increasingly being used to produce advanced tissue engineering scaffolds bionic structure optimal mechanical strength promote regeneration. However, addition excellent osteogenic induction,...
Three-dimensionally printed porous titanium alloys prepared using the electron beam melting (EBM) technology have customized structures and a low elastic modulus. They can promote repair of bone defects. Growth factors enhance biological activity plants in vivo, morphogenetic protein 9 (BMP9) is key factor for osteogenesis. The purpose this study was to evaluate implant EBM with temperature-sensitive collagen mixed recombinant human (rh) BMP9 as composite scaffold be continuously provided...
Tissue engineering technologies offer new treatment strategies for the repair of peripheral nerve injury, but cell loss between seeding and adhesion to scaffold remains inevitable. A thermosensitive collagen hydrogel was used as an extracellular matrix in this study combined with bone marrow mesenchymal stem cells construct tissue-engineered composites vitro. Dynamic culture performed at oscillating frequency 0.5 Hz 35° swing angle above below horizontal plane. The results demonstrated that...
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide. However, the pathogenesis OA unclear. Therefore, this study was conducted to characterize implicated genes OA. The gene expression profiles GSE82107 GSE55235 were downloaded from Gene Expression Omnibus database. Altogether, 173 differentially expressed including 68 upregulated 105 downregulated in patients with selected based on criteria <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The purpose of this study was to evaluate the hepatocellular compatibility and assess inflammatory response a novel hybrid scaffold poly(L-lactide) (PLLA) fibroin. obtained by freezing lyophilizing blend fibroin microspheres PLLA solution. FTIR scanning electron microscopy (SEM) analysis indicated that were on surface scaffold. Compared scaffold, SEM laser confocal microscope (LSCM) analyses showed human carcinoma HepG2 cells had spread proliferated much more in MTT...
Purpose Although proximal row carpectomy, wrist arthrodesis and even total arthroplasty were developed to treat disease using bone cartilage of the wrist, severe complicated defects caused by ferocious trauma tumors remain a stubborn problem for surgeons. Development application three-dimensional (3D) printing technology may provide possible solutions. Design/methodology/approach Computed tomography (CT) data three cases with either or tumor collected converted into models. Prostheses...
Iatrogenic spinal cord injury (SCI) is the most devastating complication of spine surgery, which usually results in permanent and serious disabilities patients.Improvement visualization discrimination critical for accuracy safety during surgery; however, to date, there no suitable technology fulfill this clinical need.Here, we first show an efficient rapid fluorescence imaging rabbit by epidural administration a nerve-highlighting fluorophore, i.e. (E, E)-1,4-bis(p-aminostryl)-2-methoxy...
Osteoarthritis (OA) poses a growing threat to the health of global population. Accumulation advanced glycation end-products (AGEs) has been shown upregulate expression degradative enzymes such as matrix metalloproteinases (MMPs) and disintegrin metalloproteinase with thrombospondin motifs (ADAMTS) in chondrocytes, which leads excessive degradation type II collagen aggrecan articular extracellular (ECM). In present study we investigated effects GLP-1 agonist lixisenatide, widely used diabetes...
Tantalum and porous tantalum are ideal materials for making orthopedic implants due to their stable chemical properties excellent biocompatibility. However, utilization is still affected by loosening, infection, peripheral inflammatory reactions, which sometimes ultimately lead implant removal. An bone should have exceptional biological activity, can improve the surrounding microenvironment enhance repair. Recent advances in surface functionalization produced various strategies developing...
ABSTACT The purpose of this study is to research the morphologies and functional characteristics cell-scaffold complex in vitro constructed under dynamic culture conditions. BMSCs were isolated from long bones Fischer344 rats, performed amplification third generation as seed cells, together with thermosensitive collagen hydrogel (TCH) cell adhesion matrix, poly-L-lactic acid (PLLA) scaffold, construct complex. complexes experiment group control then static culture. After 7 d culture, 2...