A5101481010- Immune Cell Function and Interaction
- Nitric Oxide and Endothelin Effects
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Mast cells and histamine
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- Inflammasome and immune disorders
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Multicomponent Synthesis of Heterocycles
- Angiogenesis and VEGF in Cancer
- Biomarkers in Disease Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Quinazolinone synthesis and applications
- Clusterin in disease pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Hebei University of Chinese Medicine
2023
Third Xiangya Hospital
2013-2022
Central South University
2009-2022
Second Xiangya Hospital of Central South University
2013-2022
Third People 's Hospital of Liaoyang
2017
Virginia Commonwealth University Medical Center
2009
Discoid lupus erythematosus (DLE) and systemic (SLE) are both types of lupus, yet the characteristics, differences between them not fully understood. Here we show single-cell RNA sequencing data cutaneous lesions from DLE SLE patients skin tissues healthy controls (HCs). We find significantly higher proportions T cells, B cells NK in than SLE. Expanded CCL20
Macrophage-associated inflammation and keratinocytes excessive proliferation inflammatory cytokines secretion induced by stimulation play an important role in the progression of psoriasiform dermatitis. However, how these two types cells communicate remains obscure.
Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role the pathogenesis of coronary artery disease (CAD). However, mechanism remains unclear. Regulatory factor X1 (RFX1) transcription regulating epigenetic modifications. In this study, we investigated whether RFX1 and modifications mediated by contributed to overexpression TLR4 monocytes. Compared with those controls, mRNA protein were downregulated was upregulated CD14+ monocytes obtained from...
Systemic lupus erythematosus (SLE) is an autoimmune disease that characterized by lymphocytic infiltration and overproduction of autoantibodies, leading to significant morbidity mortality. However, the pathogenesis this disorder has not yet been completely elucidated. It reported CD70, a B cell costimulatory molecule encoded gene TNFSF7 (tumor necrosis factor ligand superfamily member 7), overexpressed in CD4+ T cells from patients with SLE due demethylation its promoter. We aimed...
Previous studies have shown the regulatory effect of nitric oxide (NO) on endotoxin-induced tissue factor (TF) in endothelial cells. Asymmetric dimethylarginine (ADMA), a major endogenous NO synthase (NOS) inhibitor, could inhibit production vivo and vitro. ADMA its hydrolase dimethylaminohydrolase (DDAH) recently been thought as novel system production. The aim present study was to determine whether DDAH/ADMA pathway is involved lipopolysaccharide (LPS) TF expression Human umbilical vein...
Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (C min ) provide a reliable basis for reasonable application VRC. Methods: A total 918 VRC C from 231 patients was collected quantified using high-performance liquid chromatography in this study. The genotypes CYP2C19 , CYP3A4 CYP3A5 were detected by DNA sequencing assay. effects different coadministration investigated. Furthermore, with...
Natural killer (NK) cells are a potent weapon against tumor and viral infection. Finding active compounds with the capacity of enhancing NK cell effector functions will be effective to develop new anti-cancer drugs. In this study, we initially screened 287 commercially available by co-culturing peripheral blood mononuclear (PBMCs). We found that five compounds, namely, Daphnetin, MK-8617, LW6, JIB-04, IOX1, increased IFN-γ + ratio in presence IL-12. Further studies using purified human...
Our previous study showed that hypermethylation of dimethylarginine dimethylaminohydrolase 2 contributes to homocysteine-induced apoptosis human umbilical vein endothelial cells. Epigallocatechin-3-gallate is a green tea-derived phenol which has been proved beneficial on atherosclerosis. It was demonstrated epigallocatechin-3-gallate inhibits DNA methyltransferase activity and reactivates methylation-silenced genes in cancer The aim this address whether could induce demethylation the gene,...
Coronary artery disease (CAD) is a chronic inflammatory caused by development of atherosclerosis (AS), which the leading cause mortality and disability. Our study aimed to identify differentially expressed genes (DEGs) in CD14+ monocytes from CAD patients compared with those non-CAD controls, might pave way diagnosis treatment for CAD.The RNA-sequencing (RNA-seq) was performed BGISEQ-500, followed analyzing R package screening DEGs. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Trace element iron affects T cell biology, but the knowledge about role of in regulating Treg expansion is limited. cells play an important keeping peripheral tolerance, increasing a promising therapeutic method for SLE. Here we showed that deficiency promotes by reducing ROS accumulation, improving disease progression pristane-induced lupus. Increased oxidative stress inhibits differentiation inducing apoptosis. Our data suggest altering metabolism preventing oxidation-induced death, which...
Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role systemic lupus erythematosus (SLE) skin lesions remains unclear. Targeted oxidized lipid metabolomics analysis using liquid chromatography-mass spectrometry (LC-MS) was performed to quantify oxysterols lesions. Immunohistochemical staining and single-cell sequencing data confirmed upregulation oxysterol-encoding enzymes CH25H CYP7B1. The impact on fibroblast-mediated PBMCs chemotaxis...
Monocyte chemoattractant protein 1 (MCP1) affects the chemotaxis of monocytes and is a key chemokine closely related to development atherosclerosis (AS). Compared with healthy controls, coronary heart disease (CAD) patients show significantly upregulated plasma concentrations mRNA expression MCP1 in CD14+ monocytes. However, specific regulatory mechanism overexpression AS still unclear. Our previous research indicated that there was no significant difference H3K4 H3K27 tri-methylation...
The aim of this study was to investigate the effect demethylbellidifolin (DMB), a major xanthone compound Swertia davidi Franch, on nitroglycerin (NTG) tolerance. In in vivo portion study, pretreatment Sprague-Dawley rats with NTG (10 mg/kg) for 8 days caused tolerance depressor NTG. This evident because (150 µg/kg, i. v.) almost completely abolished tolerant rats. could be diminished by treatment DMB. vitro exposure aortic rings µM) 30 min vasodilating is substantial right shift...