A5101871195- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Genetic and rare skin diseases.
- Nail Diseases and Treatments
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Immune Response and Inflammation
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Spondyloarthritis Studies and Treatments
- Cancer and Skin Lesions
- Hematopoietic Stem Cell Transplantation
- Skin Diseases and Diabetes
- Rheumatoid Arthritis Research and Therapies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hair Growth and Disorders
- Body Image and Dysmorphia Studies
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Huazhong University of Science and Technology
2021-2024
Union Hospital
2021-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Union Hospital
2023
University of Pennsylvania
1999-2008
Center for Rheumatology
1998-2006
UConn Health
1998
Abstract It has been proposed that the “normal” stimulation of immune system occurs from interactions with environmental stimuli, whether infectious or dietary, is necessary for initiation and/or continuation autoimmunity. We tested this hypothesis by deriving a group MRL-lpr mice into germfree (GF) environment. At 5 mo age, no differences between GF and conventional were noted in lymphoproliferation, flow cytometric analysis lymph node cells (LN), histologic kidneys. Autoantibody levels...
Abstract MRL/lpr mice develop a spontaneous systemic lupus erythematosus-like autoimmune syndrome due to dysfunctional Fas receptor, with contributions from other less well-defined genetic loci. The removal of B cells by manipulation not only prevents autoantibody formation, but it also results in substantially reduced T cell activation and kidney inflammation. To determine whether depletion administration Abs is effective an intact immune system established disease, we screened several...
Chronic graft-vs-host (cGVH) disease induced by the transfer of Ia-incompatible spleen cells from one normal mouse strain (such as B6.C-H2(bm12)/KhEg (bm12)) to another C57BL/6) causes an autoimmune syndrome resembling systemic lupus erythematosus (SLE). The role host-derived T in this response is not obvious. Previous reports suggested that host might serve down-regulate syndrome. To address issue more definitively, we used CD4 knockout (KO) or CD8KO C57BL/6 (B6) mice recipients...
Abrogation of peripheral tolerance in transgenic mice that express a uniform B-cell receptor may create powerful tool to examine the molecular mechanisms underlie autoimmune response B cells. Here we report processes induce systemic lupus erythematosus-like syndrome normal mice, namely chronic graft vs host reaction, trigger autoimmunity well-established model cell tolerance. The induction reaction carry both rearranged Ag receptors specific for hen egg lysozyme and expressing chronically...
Chronic graft-vs-host (cGVH) disease is induced in nonautoimmune mice by the transfer of alloreactive T cells that recognize foreign MHC class II. It closely resembles systemic lupus erythematosus, with antinuclear Abs and immune-mediated nephritis. Recent work has implicated TLRs, particularly TLR9, recognition certain autoantigens vitro vivo. To explore further role TLR9 autoimmunity, we cGVH C57BL/6 (B6) lacking including B6 expressing anti-DNA-encoding IgH transgenes 3H9 or 56R...
Abstract Mouse bone marrow (BM) stromal cell conditioned medium (CM) from our long-term lymphoid culture system selectively induces the in vitro proliferation and presumptive differentiation of pre-pro-B cells (B220+, HSA−, TdT− or TdT+, cμ−) adult rat, mouse, human BM. However, responsible growth factor(s) has not yet been identified. Inasmuch as IL-7 is one cytokines most closely associated with early B-lineage development, we utilized BM adherent lines gene-deleted (−/−) mice combination...
B cell autoreactivity is a component of chronic graft versus host (GVH) disease in humans and mice. Chronic GVH driven by I-A disparity results loss tolerance Ig/sHEL tolerant In these mice, anergy characterized down-modulation sIgM mediated intracellular retention the endoplasmic reticulum (ER) and/or block post-ER processing IgM receptors. Here, we report that induces selective increase micro chain trafficking to surface receptors cells bind HEL self-antigen. The was detectable as early 6...
Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association SLE enable early prediction of treatment targets the future. In total, 185 SLE-diagnosed patients were enrolled categorized into two groups: those without involvement. After conducting logistic regression analysis differentiating factors, we concluded that tumor necrosis factor-alpha (TNF-α) an independent...
Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation fibroblasts, leading to a global healthcare burden. However, effective treatments fibrotic remain limited, their pathological mechanisms require further investigation. This study aims investigate common biomarkers therapeutic targets in two major diseases, namely, keloid systemic sclerosis (SSc), bioinformatics analysis. Methods: The (GSE92566) SSc (GSE95065)...
摘要： 【摘要】 抗黑素瘤分化相关基因5（MDA5）抗体阳性皮肌炎是皮肌炎的一种特殊类型，临床表现具有特征性，通常肌炎症状轻，易伴发急进性肺间质病变，预后差，发病机制尚不清楚，可能与遗传环境因素有关。本文总结近年来抗MDA5抗体阳性皮肌炎治疗进展，为临床治疗提供新思路。
摘要： 【摘要】 N6-甲基腺苷（m6A）修饰可通过影响RNA的稳定性、核运输、翻译效率、剪接及降解影响基因表达。目前研究表明，m6A修饰与黑素瘤的增殖、转移及免疫治疗抵抗等生物学行为相关，具体机制仍待研究。该文综述了m6A RNA甲基化修饰的调控及其在黑素瘤中的生物学行为及机制。