A5102935916- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Advanced Sensor and Energy Harvesting Materials
- Atherosclerosis and Cardiovascular Diseases
- Terahertz technology and applications
- Reproductive System and Pregnancy
- Biochemical Analysis and Sensing Techniques
- Synthesis and properties of polymers
- Cytokine Signaling Pathways and Interactions
- melanin and skin pigmentation
- IL-33, ST2, and ILC Pathways
- Electrospun Nanofibers in Biomedical Applications
- Endometriosis Research and Treatment
- Systemic Sclerosis and Related Diseases
- Cutaneous lymphoproliferative disorders research
- Spectroscopy and Chemometric Analyses
- Mycobacterium research and diagnosis
- Reproductive Physiology in Livestock
- Advanced Chemical Sensor Technologies
- Monoclonal and Polyclonal Antibodies Research
- Adhesion, Friction, and Surface Interactions
- Clostridium difficile and Clostridium perfringens research
- Vasculitis and related conditions
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2023-2025
Beijing Institute of Fashion Technology
2024
Henan University of Technology
2024
Henan Provincial Eye Hospital
2024
Dalian University of Technology
2024
Obstetrics and Gynecology Hospital of Fudan University
2008
Discoid lupus erythematosus (DLE) and systemic (SLE) are both types of lupus, yet the characteristics, differences between them not fully understood. Here we show single-cell RNA sequencing data cutaneous lesions from DLE SLE patients skin tissues healthy controls (HCs). We find significantly higher proportions T cells, B cells NK in than SLE. Expanded CCL20
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas regulatory (Tfr) inhibit Tfh-mediated GC responses. Aberrant activation Tfh contributes substantially to pathogenesis autoimmune diseases, such as systemic lupus erythematosus (SLE). Nonetheless, molecular mechanisms mitigating excessive cell differentiation not fully understood. Herein we demonstrate that adenovirus E4 promoter-binding protein (E4BP4) mediates a feedback loop and...
Abstract Background Lupus erythematosus (LE) is a spectrum of autoimmune diseases. Due to the complexity cutaneous LE (CLE), clinical skin image‐based artificial intelligence still experiencing difficulties in distinguishing subtypes LE. Objectives We aim develop multimodal deep learning system (MMDLS) for human‐AI collaboration diagnosis subtypes. Methods This multi‐centre study based on 25 institutions across China assist subtypes, other eight similar diseases and healthy subjects. In...
Cotton fiber fabric with practicability and functionality attracts much attention plays an important role in many occasions. However, its surface contains hydroxyl groups to show a hydrophilicity, leading easy adhesion stains limit the application. In this work, polyglycidyl methacrylate (PGMA) was used as oily flexible matrix graphene oxide (GO) particles were filler. PGMA/GO composite modified fabrics hydrophobicity, self-cleaning feature wear resistance prepared by constructing coatings....
The variety and content of high-quality proteins in sunflower seeds are higher than those other cereals. However, can suffer from abnormalities, such as breakage deformity, during planting harvesting, which hinder the development seed industry. Traditional methods manual sensory machine sorting highly subjective cannot detect internal characteristics seeds. spectral imaging technology has facilitated application terahertz waves quality inspection seeds, owing to its advantages...
Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) potentially implicated in vitiligo development and progression. It was recently discovered metabotropic glutamate receptor 4 (mGluR4) can modulate Th17-mediated adaptive immunity. However, the influence mGluR4 on melanogenesis melanocytes has yet to be elucidated. In present study, we primarily cultured mouse bone marrow-derived...