A5017553729- RNA modifications and cancer
- Covalent Organic Framework Applications
- Cancer-related molecular mechanisms research
- Metal-Organic Frameworks: Synthesis and Applications
- Electrocatalysts for Energy Conversion
- Climate change and permafrost
- Acute Ischemic Stroke Management
- Cryospheric studies and observations
- Advanced Nanomaterials in Catalysis
- Winter Sports Injuries and Performance
- Fuel Cells and Related Materials
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- TGF-β signaling in diseases
- Systemic Lupus Erythematosus Research
- Lipid metabolism and disorders
- Stroke Rehabilitation and Recovery
- Immune Cell Function and Interaction
- Body Composition Measurement Techniques
- Advanced Fiber Optic Sensors
- Advanced battery technologies research
- Photoacoustic and Ultrasonic Imaging
- Vitamin D Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Central South University
2021-2025
Shandong Provincial Hospital
2024-2025
Shandong First Medical University
2024-2025
Xiangya Hospital Central South University
2025
Peking Union Medical College Hospital
2019-2024
Cardiff University
2024
Beijing Friendship Hospital
2024
Harbin Medical University
2024
Shanghai Jiao Tong University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Herein, an approach is reported for fabrication of Co-Nx -embedded 1D porous carbon nanofibers (CNFs) with graphitic carbon-encased Co nanoparticles originated from metal-organic frameworks (MOFs), which further explored as a bifunctional electrocatalyst both oxygen reduction reaction (ORR) and evolution (OER). Electrochemical results reveal that the prepared by pyrolysis at 1000 °C (CoNC-CNF-1000) exhibits excellent catalytic activity toward ORR favors four-electron process outstanding...
This study was initiated to screen for marine bacterial agents biocontrol Magnaporthe grisea, a serious fungal pathogen of cereal crops. A strain, isolated from the cold seep in deep sea, exhibited strong growth inhibition against M. and strain identified designated as Bacillus sp. CS30. The corresponding antifungal were purified by acidic precipitation, sequential methanol extraction, Sephadex LH-20 chromatography, reversed phase high-performance liquid chromatography (RP-HPLC), two peaks...
Abstract G protein-coupled receptors (GPCRs) are important drug targets that mediate various signaling pathways by activating proteins and engaging β-arrestin proteins. Despite its importance for the development of therapeutics with fewer side effects, underlying mechanism controls balance between these modes GPCRs remains largely unclear. Here, we show assembly into dimers oligomers can influence mode platelet-activating factor receptor (PAFR). Single-particle analysis results PAFR form at...
Abstract Timely restoration of blood supply after myocardial ischemia is imperative for the treatment acute infarction but causes additional ischemia/reperfusion (MI/R) injury, which has not been hitherto effectively targeted by interventions MI/R injury. Hence, development advanced nanomedicine that can reduce apoptosis cardiomyocytes while protecting against in vivo utmost importance. Herein, a redox‐responsive and emissive TPE‐ss covalent organic framework (COF) nanocarrier integrating...
Covalent organic frameworks (COFs) have garnered enormous attention in anti-cancer therapy recently. However, the intrinsic drawbacks such as poor biocompatibility and low target-specificity greatly restrain full clinical implementation of COF. Herein, we report a biomimetic multifunctional COF nanozyme, which consists AIEgen-based (TPE-s COF) with encapsulated gold nanoparticles (Au NPs). The nanozyme was co-cultured HepG2 cells until cell membrane fused lipophilic TPE-s COF-Au@Cisplatin....
Abstract Gallbladder cancer is a rare but fatal malignancy. However, the mechanisms underlying gallbladder carcinogenesis and its progression are poorly understood. The function of m6A modification regulators was still unclear for cancer. current study seeks to investigate YTH RNA‐binding protein 1 (YTHDF1) in Transcriptomic analysis immunochemical staining YTHDF1 tissues revealed upregulation compared paracancerous tissues. Moreover, promotes proliferation assays, Transwell migration...
In this study, adenosine triphosphate (ATP)-related compounds and free amino acids were determined to study the changes of water-soluble flavor substances in grass carp meat during steaming for 18 min. Sensory assessment, electronic tongue, equivalent umami concentration (EUC) value, taste active value (TAV) also performed obtain best quality steamed meat. The results showed that presented by nucleotides three parts was better within 9 bitter dorsal red significantly decreased at 6 min...
Abstract Macrophage activation participates in the pathogenesis of pulmonary inflammation. As a coenzyme, vitamin B6 (VitB6) is mainly involved metabolism amino acids, nucleic glycogen and lipids. We have previously reported that AMP‐activated protein kinase (AMPK) produces anti‐inflammatory effects both vitro vivo. Whether VitB6 via AMPK prevents inflammation remains unknown. The model acute pneumonia was induced by injecting mice with lipopolysaccharide (LPS). determined measuring levels...
Background. The screening and early detection of colorectal cancer (CRC) still remain a challenge due to the lack reliable effective serum biomarkers. Thus, this study is aimed at identifying biomarkers CRC that could be used distinguish from healthy controls. Methods. A prospective 1 : 2 individual matching case-control was performed which included 50 control subjects 98 patients. Untargeted metabolomic profiling conducted with liquid chromatography tandem mass spectrometry (LC-MS/MS)...
Abstract With the development of biotherapeutic field, biomacromolecules with definite curative and small side effects have gradually become a hot spot in research new drugs. However, use as drug candidates pose some technical difficulties related to their medicinal properties, mainly stability vivo transport delivery. Currently, diverse nanodrug delivery systems been used deliver because they can maintain stability, significantly increase bioavailability, improve targeted distribution...
Covalent organic frameworks (COFs) have revealed enormous application prospects for cancer therapeutics recently, but their assembly systems face considerable challenges, such as the codelivery of hydrophobic and hydrophilic protein drugs with different physicochemical properties in vivo delivery release, well endosomal/lysosomal escape drugs. To address these issues, we leveraged high specific surface area, lipotropism, structural tunability boronate ester-linked COFs (COF-1) construction...