A5006971248- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- GDF15 and Related Biomarkers
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Tissue Engineering and Regenerative Medicine
- Circadian rhythm and melatonin
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- COVID-19 diagnosis using AI
- Macrophage Migration Inhibitory Factor
- PARP inhibition in cancer therapy
- Melanoma and MAPK Pathways
- Coronary Interventions and Diagnostics
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- Stress Responses and Cortisol
- Galectins and Cancer Biology
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Qilu Hospital of Shandong University
2014-2023
State Key Laboratory for Innovation and Transformation of Luobing Theory
2023
People's Hospital of Cangzhou
2022
Shandong University
2013-2021
National Natural Science Foundation of China
2012
Abstract Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement cardiac function via regulating autophagy remains unclear. We investigated mechanisms underlying resveratrol‐mediated protection against heart failure mice, with focus role of sirtuin 1 ( SIRT 1) autophagic flux. Diabetic cardiomyopathy mice was induced by streptozotocin STZ ). Long‐term resveratrol treatment improved...
Abstract Heart failure with preserved ejection fraction (HFpEF) is associated endothelial dysfunction. We have previously reported that statins prevent dysfunction through inhibition of microRNA-133a (miR-133a). This study to investigate the effects and underlying mechanisms on HFpEF. Here, we show upregulate expression a circular RNA (circRNA-RBCK1) which co-transcripted ring-B-box-coiled-coil protein interacting kinase C-1 (RBCK1) gene. Simultaneously, increase activator 2 alpha (AP-2α)...
Background . Myocardial infarction (MI) is a major cause of morbidity and mortality in the world. Tongxinluo (TXL) traditional Chinese compound prescription which has cardioprotective functions. The present study was aimed to determine effect TXL on postischemic cardiac dysfunction remodeling elucidate underlying mechanisms. Methods Results MI performed by ligation left anterior descending coronary artery (LAD) male adult mice. Mice were randomly divided into four groups: (1) sham group...
Background It has been demonstrated that Tongxinluo (TXL), a traditional Chinese medicine compound, improves ischemic heart disease in animal models via vascular endothelial growth factor (VEGF) and nitric oxide synthase (eNOS). The present study aimed to investigate whether TXL protects against pressure overload–induced failure mice explore the possible mechanism of action. Methods Results Transverse aortic constriction (TAC) surgery was performed induce failure. Cardiac function evaluated...
Abstract Macrophage activation participates in the pathogenesis of pulmonary inflammation. As a coenzyme, vitamin B6 (VitB6) is mainly involved metabolism amino acids, nucleic glycogen and lipids. We have previously reported that AMP‐activated protein kinase (AMPK) produces anti‐inflammatory effects both vitro vivo. Whether VitB6 via AMPK prevents inflammation remains unknown. The model acute pneumonia was induced by injecting mice with lipopolysaccharide (LPS). determined measuring levels...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019 and rapidly spread to other provinces China as well countries. In this study, 262 patients diagnosed with moderate SARS-CoV-2 pneumonia Wuhan, China, were analyzed. Data compared between survivors nonsurvivors. Of all the patients, 23 (8.8%) died 239 (91.2%) discharged. median age was 63.5 years 46.9% of male. main complaints fever (83.6%), cough (63.4%), fatigue (49.2%) surviving group, while there more...
Abdominal aortic aneurysm (AAA) is a common vascular degenerative disease. PARP-1 (poly[ADP-ribose] polymerase 1) nuclear enzyme, which plays critical role in diseases. We hypothesized that inhibition might have protective effects on AAA. In vivo, Ang II (angiotensin II) was continuously infused by micropump for 28 days to induce AAA mice. vitro, endothelial cells and smooth muscle were stimulated 24 hours. infusion increased expression activity successfully induced formation partly with...
Cardiac fibrosis is a key factor to determine the prognosis in patient with myocardial infarction (MI). The aim of this study investigate whether transcriptional paired-related homeobox 2 (Prrx2) regulates Wnt5a gene expression and role following MI. MI surgery was performed by ligation left anterior descending coronary artery. remodelling assessed measuring interstitial Masson staining. Cell differentiation examined analysis alpha-smooth muscle actin (α-SMA). Both Prrx2 expressions were...
Objectives Endothelial progenitor cells (EPCs) can be used to repair tissues after myocardial infarction (MI) but EPC activators have adverse reactions. Rehmannia glutinosa is a herb in traditional Chinese medicine, which promote bone-marrow proliferation and protect the ischemic myocardium. We investigated effects of extract (RGE) on EPCs rat model MI. Methods A total 120 male Wistar rats were randomized 2 groups (n = 60 each) for treatment: high-dose RGE (1.5 g·kg−1·day−1 orally) 8 weeks,...
Abstract Cellular therapeutic neovascularization has been successfully performed in clinical trials for patients with ischaemia diseases. Despite the vast knowledge of cardiovascular disease and circadian biology, role clock regulating angiogenesis myocardial infarction ( MI ) remains poorly understood. In this study, we aimed to investigate underlying mechanisms Period 2 (Per2) endothelial progenitor cell EPC function. Flow cytometry revealed lower circulating proportion per2 −/− than...
Abstract Collateral circulation is essential for blood resupply to the ischemic heart, which dictated by contractile phenotypic restoration of vascular smooth muscle cells (VSMC). Here we investigate whether S-nitrosylation AMP-activated protein kinase (AMPK), a key regulator VSMC phenotype, impairs collateral circulation. In rats with growth and development, nitroglycerin decreases coronary flow (CCBF), inhibits restoration, increases myocardial infarct size, accompanied reduced AMPK...
Cardiomyocyte apoptosis is a characteristic of variety cardiac diseases, including myocardial infarction (MI). Krüppel-like factor 15 (KLF15) transcription Krüppel family that plays an important part in cardiovascular diseases. However, the function and underlying mechanism KLF15 MI remain unknown. The expression was downregulated both ischemic myocardium mice model hypoxia-treated neonatal rat ventricular myocytes (NRVCs). overexpression mediated by adeno-associated virus significantly...
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Angiotensin (Ang) IV possesses many biological properties that are not yet completely understood. Therefore, we investigated the function mechanism Ang in AMI vivo vitro conditions. was performed by ligation left anterior descending coronary artery (LAD) male C57 mice. continuously infused minipump 3 d before for 33 d. The neonatal rat ventricular myocytes (NRVCs) were stimulated with cultured under...
Objective: Vascular dementia is the second leading cause of dementia, which strongly associated with diabetes. Ectopic expression miR-133a in endothelial cells involved dysfunction Whether berberine, as a natural product Coptis chinensis, improves vascular induced by diabetes remains unknown.Methods: Diabetes and subsequent were rats injecting streptozotocin (50 mg/kg/day) for five consecutive days. The was determined fluorescence situ hybridization. learning memory evaluated step-down,...
Objectives Chronic psychological stress is associated with an increased risk of atherosclerosis in humans. Experimental studies using various models have yielded controversial results. This study investigated the effects unpredictable chronic mild (UCMS) on atherogenesis New Zealand white rabbits. Methods Rabbits were fed a cholesterol-enriched (1%) diet for 4 to 16 weeks, or without concomitant UCMS treatment. Atherosclerosis was assessed abdominal aorta by serial sectioning and...
Background In the clinic, variations in circadian rhythm are evident patients with cardiovascular disease, and risk of events increases when rhythms disrupted. this study, we focused on role gene period2 (per2) mobilization function endothelial progenitor cells (EPCs) vitro vivo after myocardial infarction (MI) mice. Methods Results MI was produced by surgical ligation left anterior descending coronary artery mice without per2 deficiency. Trans-thoracic echocardiography used to evaluate...
A major side effect of statin, a widely used drug to treat hyperlipidemia, is skeletal myopathy through cell apoptosis. The aim this study investigate the roles microRNA in statin-induced injury.Apolipoprotein E knockout (ApoE-/-) mice were administered with simvastatin (20 mg/kg/day) for 8 weeks. Exercise capacity was evaluated by hanging grid test, forelimb grip strength, and running tolerance test.In cultured muscle cells, statin increased levels miR-1a but decreased mitogen-activated...
The aim of the present study was to elucidate significance secreted protein acidic and cysteine rich (SPARC) expression in non-small cell lung cancer (NSCLC) terms clinicopathology, immune-cell infiltration survival prognosis. A meta-analysis bioinformatics analysis were performed using studies retrieved with PubMed, Web Science, Wanfang Data Chinese National Knowledge Infrastructure databases. suggested that, compared normal tissues, SPARC elevated NSCLC tissues. not significantly...
Qindan capsule (QC), a traditional Chinese medicine compound, has been used to treat hypertension in the clinic for over 30 years. It is still not known about effects of QC on pressure overload-induced cardiac remodeling. Hence, this study aims investigate hypertrophy, fibrosis, and heart failure mice determine possible mechanisms. Transverse aortic constriction (TAC) surgery was induce hypertrophy C57BL/6 mice. Mice were treated with or losartan 8 weeks after TAC surgery. Cardiac function...
Backgrounds: Cardiac fibrosis is a key factor to determine the prognosis in patient with myocardial infarction (MI). Activation of Wnt signaling by transforming growth β (TGF-β) contributes cell differentiation fibroblasts cardiac remodeling. However, molecular mechanisms how protein family 5a (Wnt5a) upregulated post-ischemic heart are still mostly unclear. The aim this study investigate whether paired-related homeobox 2 (Prrx2), as transcriptional factor, regulates Wnt5a gene expression...