A5101493507- Genomics and Chromatin Dynamics
- ECG Monitoring and Analysis
- Estrogen and related hormone effects
- Magnetic and transport properties of perovskites and related materials
- Enzyme Structure and Function
- Sepsis Diagnosis and Treatment
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Phonocardiography and Auscultation Techniques
- Imbalanced Data Classification Techniques
- Biopolymer Synthesis and Applications
- Machine Learning in Materials Science
- Inflammasome and immune disorders
- Magnetic properties of thin films
- Thermal Expansion and Ionic Conductivity
- Mollusks and Parasites Studies
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Anomaly Detection Techniques and Applications
- HIV-related health complications and treatments
- Tryptophan and brain disorders
- Topic Modeling
- Calcium signaling and nucleotide metabolism
- COVID-19 diagnosis using AI
Case Western Reserve University
2023-2025
Tongji University
2024
Shanghai Institute of Pollution Control and Ecological Security
2024
Sichuan Agricultural University
2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Qilu Hospital of Shandong University
2023
State Key Laboratory for Innovation and Transformation of Luobing Theory
2023
The Affiliated Hospital to Changchun University of Chinese Medicine
2023
Shanxi Academy of Medical Sciences
2023
Fiber-shaped stretchable strain sensors with small testing areas can be directly woven into textiles. This paves the way for design of integrated wearable devices capable obtaining real-time mechanical feedback various applications. However, a simple fiber that undergoes uniform distribution during deformation, it is still big challenge to obtain high sensitivity. Herein, new strategy, surface redistribution, reported significantly enhance sensitivity fiber-shaped sensors. A method transient...
The oestrogen receptor (ER or ERα), a nuclear hormone that drives most breast cancer1, is commonly activated by phosphorylation at serine 118 within its intrinsically disordered N-terminal transactivation domain2,3. Although this modification enables oestrogen-independent ER function, mechanism has remained unclear despite ongoing clinical trials of kinase inhibitors targeting region4–6. By integration small-angle X-ray scattering and magnetic resonance spectroscopy with functional studies,...
Spin-orbit-torque (SOT) symmetry in a heavy-metal--ferromagnet bilayer forbids the deterministic switching of perpendicular magnetization. Traditionally, an external magnetic field-exchange bias-tilted anisotropy is introduced to break symmetry, which not suitable for practical applications. Here, we propose SOT by introducing longitudinal composition gradient $\mathrm{Cu}\text{\ensuremath{-}}\mathrm{Pt}$ heavy metal. We demonstrate perpendicularly magnetized $\mathrm{Co}/\mathrm{Ni}$...
Abstract Objective . Cardiovascular disease is a major threat to health and one of the primary causes death globally. The 12-lead ECG cheap commonly accessible tool identify cardiac abnormalities. Early accurate diagnosis will allow early treatment intervention prevent severe complications cardiovascular disease. Our objective develop an algorithm that automatically identifies 27 abnormalities from databases. Approach Firstly, series pre-processing methods were proposed applied on various...
Comorbidity among cancer patients is prevalent and influential to prognosis after operation. Limited data are available on comorbidity evaluations in with intrahepatic cholangiocarcinoma (ICC). This study aimed assess the distribution ICC adapt Charlson Index (CCI) or age-adjusted CCI (ACCI) for survival prediction.The cohort included 268 treated curative surgery from January 2000 December 2007 at Department of Liver Surgery, Zhongshan Hospital. The association between index overall (OS)...
In PhysioNet/Computing in Cardiology Challenge 2020, we developed an ensembled model based on SE-ResNet to classify cardiac abnormalities from 12-lead electrocardiogram (ECG) signals.We employed two residual neural network modules with squeeze-and-excitation blocks learn the first 10-second and 30-second segments of used external open-source data for validation fine-tuning during development phase.We designed a multi-label loss emphasize impact wrong predictions training.We built rule-based...
Abstract Collateral circulation is essential for blood resupply to the ischemic heart, which dictated by contractile phenotypic restoration of vascular smooth muscle cells (VSMC). Here we investigate whether S-nitrosylation AMP-activated protein kinase (AMPK), a key regulator VSMC phenotype, impairs collateral circulation. In rats with growth and development, nitroglycerin decreases coronary flow (CCBF), inhibits restoration, increases myocardial infarct size, accompanied reduced AMPK...
Poultry farming is an indispensable part of global agriculture, playing a crucial role in food safety and economic development. Managing preventing diseases vital task the poultry industry, where semantic segmentation technology can significantly enhance efficiency traditional manual monitoring methods. Furthermore, has achieved excellent results on extensively manually annotated datasets, facilitating real-time poultry. Nonetheless, model encounters limitations when exposed to new...
Clinical performance audits are routinely performed in Emergency Medical Services (EMS) to ensure adherence treatment protocols, identify individual areas of weakness for remediation, and discover systemic deficiencies guide the development training syllabus. At present, these by manual chart review, which is time-consuming laborious. In this paper, we report a weakly-supervised machine learning approach train named entity recognition model that can be used automatic EMS clinical audits. The...
PTGES3, also known as p23, is a molecule chaperone of Hsp90 that involved in the pathogenesis malignant tumors. Increasing studies have shown PTGES3 plays nonnegligible role tumor development. However, analysis pan-cancer has not been performed yet.We explored 33 types tumors and depicted potentialimmune-related pathways among them. Using multiple databases includingTCGA, LinkedOmics, GDSC, TIMER, we made comprehensive to explore whether there was an interaction between prognosis, DNA...
Abstract Protein intrinsic disorder is coupled to a range of biological phenomena, from gene regulation cancer progression. Phosphorylation the estrogen receptor (ER) at Ser118 through its disordered N-terminal domain (NTD) activates transcriptional function, but it challenging rationalize how this modification regulates ER activity. Using biophysical approaches small-angle X-ray scattering and nuclear magnetic resonance spectroscopy, we demonstrate that phosphorylation triggers long-range...
Abstract Background Combined with the increasing life expectancy, chronic medical conditions have gradually become dominant cause of death and disability, multimorbidity became an increasingly serious public health challenge. However, most existing studies focused on coexistence specific diseases or relatively few diseases. Given one person may multiple at same time, we applied Charlson Comorbidity Index (CCI) to systematically evaluate one’s 10-year mortality. In this study, explored...
The occurrence of linear cholesterol-recognition motifs in alpha-helical transmembrane domains has long been debated. Here, we demonstrate the ability a genetic algorithm guided by coarse-grained molecular dynamics simulations—a method coined evolutionary (Evo-MD)—to directly resolve sequence which maximally attracts cholesterol for single-pass (TMDs). We illustrate that landscape attraction membrane proteins is characterized sharp, well-defined global optimum. Surprisingly, this optimal...
The objective of this study is to the sedative and hypnotic effects compatibility Schisandra chinensis (SC) Polygala tenuifolia (PT) on insomnia mice its mechanisms. 160 SPF KM were divided into 8 groups with 20 each group (10 female 10 male mice), including control, model, estazolam, SC, PT, SC-PT 1:1, 1:2, 2:1 group. Insomnia model was established intraperitoneal injection P-chlorophenylalanine (PCPA) for 3 days. investigated by sleep time induced pentobarbital sodium, levels GABA, DA,...
To characterise gout patients at high risk of hospitalisation and to develop a web-based prognostic model predict the likelihood gout-related hospital admissions. This was retrospective single-centre study 1417 presenting emergency department (ED) with flare between 2015 2017 1-year look-back period. The dataset randomly divided, 80% forming derivation remaining validation cohort. A multivariable logistic regression used determine from in coefficients for variables statistically significant...