A5101543556- Cancer Cells and Metastasis
- Soil Carbon and Nitrogen Dynamics
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Regulation of Appetite and Obesity
- Pluripotent Stem Cells Research
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Forest ecology and management
- Colorectal Cancer Surgical Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Apelin-related biomedical research
- Biochemical Analysis and Sensing Techniques
- Ubiquitin and proteasome pathways
- Nitric Oxide and Endothelin Effects
- Gastroesophageal reflux and treatments
- Soil erosion and sediment transport
- Esophageal Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- CRISPR and Genetic Engineering
Nanchang University
2016-2024
Huawei Technologies (China)
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Guangxi University
2022-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
Second Affiliated Hospital of Nanchang University
2016-2023
First Affiliated Hospital of Zhengzhou University
2020-2023
Dongguan People’s Hospital
2012-2022
First Affiliated Hospital of Nanchang University
2019-2022
First Affiliated Hospital Zhejiang University
2018-2022
Systemic inflammatory parameters, such as the elevator PLR (platelet-lymphocyte ratio), NLR (neutrophil-lymphocyte ratio) and platelet count (PLT), have been found to be associated with prognosis in gastric cancer; however, these results, especially those relating PLR, remain inconsistent. So we aimed evaluate prognostic role of cancer by conducting presenting findings this meta-analysis.We conducted a systematic literature search PubMed, Embase Cochrane Library value cancer. The quality...
Activation of leukemia inhibitor factor (LIF)/Stat3 or Wnt/β-catenin signaling promotes mouse embryonic stem cell (mESC) self-renewal. A myriad downstream targets have been identified in the individual signal pathway, but their common remain largely elusive. In this study, we found that LIF/Stat3 and pathways converge on Sp5 to promote mESC Forced expression can reproduce partial effects mimics most features maintain undifferentiated mESCs. Moreover, is able convert epiblast cells a naïve...
Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype, we identified trifluoperazine (TFP) as compound interferes with this phenotype conversion. TFP causes loss radiation-induced Nanog mRNA expression, activation GSK3 consecutive posttranslational...
Abstract Climate warming and anthropogenic nitrogen (N) loads are two major global change components interactively affecting carbon cycling. However, the effects of N forms amounts on temperature sensitivity (Q 10 ) soil organic matter (SOM) mineralization remain incomplete. With this goal, was sampled after 23 years mineral (or) fertilization, then incubated for one year at 10, 20, 30°C. For first time, we compared four approaches (Equal Equal C, 1‐C pool, 2‐C pool model) to evaluate Q SOM...
Glioblastoma is the deadliest brain tumor in adults, and standard of care consists surgery followed by radiation treatment with temozolomide. Overall survival times for patients suffering from glioblastoma are unacceptably low indicating an unmet need novel options.Using patient-derived HK-157, HK-308, HK-374, HK-382 lines, GL261 orthotopic mouse models glioblastoma, HK-374 xenografts, we tested effect dopamine receptor antagonist quetiapine on self-renewal vitro vivo. A possible resistance...
Atherosclerotic cardiovascular disease (ASCVD) is one of the biggest threats to public health worldwide. It shows a trend high incidence rate and younger age. Abnormal lipid metabolism main risk factor. The residual remnant cholesterol (RC) has been studied recently. However, distribution with gender age rarely reported. Data were collected from laboratory information system September 1, 2022, through March 31, 2023. TC, HDL-C, LDL-C measured using Roche cobas 8000 c701 automatic biochemical...
Abstract Diabetic kidney disease (DKD) is one of the most common complications diabetes, and cause end-stage renal disease, for which no effective therapies are yet available. RNA-binding proteins (RBPs) play a pivotal role in epigenetic regulation; tristetraprolin (TTP) human antigen R (HuR) competitively bind cytokine mRNAs, exert contrasting effects on RNA stability, drive inflammation. However, RBPs’ roles diabetes-related glomerulopathy poorly understood. Herein, we investigated whether...
It is widely accepted that aldehyde dehydrogenase (ALDH) activity a signature of breast cancer stem cells, and high has been reported to be associated with poor clinical outcome. The aim this study was assess the expression members ALDH family isozymes in tissues evaluate implications results. We analyzed paraffin-embedded tumor tissue from 160 patients cancer. Immunohistochemistry (IHC) staining performed on slides using antibodies against different members. collated IHC results patient...
Abstract Aims/Introduction Angiotensin‐(1–7) (Ang‐[1–7]), recognized as a new bioactive peptide in the renin–angiotensin system, shows biological and pharmacological properties diabetic cardiovascular diseases. The leptin‐induced p38 mitogen‐activated protein kinase (MAPK) pathway has been reported to contribute high glucose (HG)‐induced injury. In present study, we showed mechanism of how Ang‐(1–7) can protect against HG‐stimulated injuries H9c2 cells. Materials Methods cells were treated...
It is well established that breast cancer stem cells (BCSCs) play an essential role in tumor invasion for both local and distant metastasis. The aim of this study was to establish whether BCSCs could act as a prognostic clinical marker. We analyzed tissues from 161 patients. Dual immunohistochemistry immunofluorescence were performed on all the slides, we relationship between EpCAM(-)/CD49f(+) key factors. Univariate survival analysis using Kaplan-Meier method showed presence significantly...
// Zheng-Shui Xu 1, # , Hua Cheng 2, Yuhong Xiao 3, Jia-Qing Cao 2 Fei Wen-Ji Jia-Qi Ying Jun Luo 4, * and Wei 1 Department of General Surgery, Xi'an N0.4 Hospital, 710000 Xi'an, Shanxi, China The Second Affiliated Hospital Nanchang University, 330006 Nanchang, Jiangxi, 3 Clinical Medical College, 4 Rehabilitation Medicine, These authors contributed equally to this study share first authorship corresponding Correspondence to: Xu, email: xu_wei111@126.com Luo, luojun1786@163.com Keywords:...
Abstract The objective of the study was to identify mechanism action for a radiation mitigator gastrointestinal (GI) acute syndrome (ARS), identified in an unbiased high-throughput screen. We used mice irradiated with lethal dose and treated daily injections 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine its effects on key pathways involved intestinal stem cell (ISC) maintenance. RNASeq, quantitative reverse transcriptase-polymerase chain reaction, immunohistochemistry were performed engaged...
Cancer is frequently associated with tumor-related anemia, and many chemotherapeutic agents impair hematopoiesis, leading to impaired quality of life for affected patients. The use erythropoiesis-stimulating has come under scrutiny after prospective clinical trials using recombinant erythropoietin correct anemia reported increased incidence thromboembolic events cancer-related deaths. Furthermore, previous preclinical reports indicated expansion the pool breast cancer-initiating cells when...