A5043141171- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Chemical Synthesis and Characterization
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Groundwater and Isotope Geochemistry
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Biology and Fertility
- Lipoproteins and Cardiovascular Health
- Reproductive System and Pregnancy
- Traumatic Brain Injury and Neurovascular Disturbances
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Ferroptosis and cancer prognosis
- Chronic Kidney Disease and Diabetes
Meizhou City People's Hospital
2023-2025
Peking University
2003-2024
Peking University Third Hospital
2016-2024
Guangdong Provincial Academy of Building Research Group
2023
Abstract Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of proteome. Thus, deep and unbiased proteomic analysis circulating holds promise for discovering disease biomarkers as well revealing mechanisms. We established workflow simple, deep, reproducible proteome both serum small EVs enriched fractions by ultracentrifugation plus 4D-data-independent acquisition mass spectrometry (4D-DIA-MS). In our...
Human urine-derived stem cells (USCs) protect rats against kidney ischemia/reperfusion (I/R) injury. Here we investigated the role of USCs exosomes (USCs-Exos) in protecting tubular endothelial and miRNA transfer kidney. USCs-Exos were isolated verified by morphology specific biomarkers. USC-Exos played a protective human proximal epithelial (HK-2) exposed to hypoxia/reoxygenation (H/R). rich miR-216a-5p, which targeted phosphatase tensin homolog (PTEN) regulated cell apoptosis through Akt...
Background: Common polymorphisms within the apolipoprotein E (APOE) gene are rs429358 and rs7412, which result in three major alleles (ɛ2, ɛ3, ɛ4) six genotypes (E2/E2, E2/E3, E3/E3, E3/E4, E4/E4, E2/E4).Although APOE have been suggested to be associated with development of diabetic nephropathy (DN), their potential association remains unclear different regions.This study aims unveil genetic effects on DN susceptibility serum lipid profiles southern Chinese population.Methods: A total 306...
Abstract Aim Pregnancy is a hypercoagulability state, the aim of this study was to observe changes thrombin–antithrombin complex (TAT), thrombomodulin (TM), tissue plasminogen activator‐inhibitor (tPAI‐C) and plasmin‐α2–antiplasmin (PIC) during pregnancy establish trimester‐specific reference intervals for Chinese healthy pregnant women. Methods In total 190 women (first trimester 59 cases, second 60 cases third 71 cases) were recruited in North China. TAT, TM, tPAI‐C PIC processed on Sysmex...
The lithium concentrations in the geothermal waters of Wumishan Formation carbonate reservoir China Xiong’an New Area are over 1 mg/L and even higher than those granite reservoirs some areas China. It is still unknown which most important factors controlling study area. This article selected analysis test data 32 water samples obtained recent years from area combined them with hydrochemical other regions to enrichment mechanism results indicate that lithology, pH, water–rock interaction...
Obstetric antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis or recurrent fetal loss. In this study, we aim to explore the pathological mechanism of OAPS. Herein, carried out data-independent acquisition (DIA) mass spectrometry quantitative proteomic analysis serum samples from OAPS patients and healthy controls. A set 93 differentially expressed proteins was identified, including 75 upregulated 18 downregulated compared with levels in Those are enriched...
Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disorder with severe life-threatening complications shown during pregnancy. It has been reported that the increase in CD16+CD56dim natural killer (NK) cells peripheral blood are risk factors for recurrent miscarriages, but this expression of NK OAPS patients not reported, and mechanism clearly illustrated. In study, we compared distributional profiles different cell subsets expressions cell-activating receptors healthy women. Our...
ABSTRACT Toward the end of 2022, cessation China's “dynamic zero‐COVID policy” had led to a notable outbreak SARS‐CoV‐2 infections and substantial number severe cases deaths were reported, which raised serious concerns. Concurrently, our study identified significant increase in incidence indeterminate results from Interferon‐γ Release Assay (IGRA) among hospitalized patients during this period. Peripheral T cells these individuals unable produce measurable levels IFN‐γ upon stimulation with...
Objective To investigate the application of combined detection three serum markers, anti-cyclic citrullinated peptide antibody (anti-CCP), rheumatoid factor (RF), anti-keratin antibodies (AKA), for diagnosis arthritis. Methods This was a prospective study.Serum samples were randomly obtained from 137 RA patients, 265 other autoinmmune diease and 111 normal controls.All volunteers outpatients or inpatients Peking University Third Hospital January 2011 to September 2013.Levels AKA,...