A5102890269- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Catalytic C–H Functionalization Methods
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Catalytic Cross-Coupling Reactions
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- X-ray Diffraction in Crystallography
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Genetics, Bioinformatics, and Biomedical Research
- CAR-T cell therapy research
- Silk-based biomaterials and applications
- Skin and Cellular Biology Research
- Phagocytosis and Immune Regulation
Sun Yat-sen University
2023-2025
Fourth Affiliated Hospital of China Medical University
2019-2024
China Medical University
2019-2024
Second Affiliated Hospital of Zhejiang University
2024
Xiamen University
2021-2024
Harbin Medical University
2022-2024
Beijing Forestry University
2024
Chinese PLA General Hospital
2017-2024
Harbin Institute of Technology
2023-2024
Peking University Third Hospital
2019-2023
Abstract After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty and other substances facilitate their unlimited proliferation. As such, the metabolism of is intricately linked survival progression cancer cells. Consequently, targeting presents a promising strategy inhibit growth cell development. This review describes uptake, metabolism, transport in its pivotal role biosynthesis more. Furthermore, we have also summarized...
The treatment of bone defects has plagued clinicians. Exosomes, the naturally secreted nanovesicles by cells, exhibit great potential in defect regeneration to realize cell-free therapy. In this work, we successfully revealed that human umbilical cord mesenchymal stem cells-derived exosomes could effectively promote proliferation, migration, and osteogenic differentiation a murine calvariae preosteoblast cell line vitro. Considering long period regeneration, exert reparative effect exosomes,...
Abstract Long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually because of the great importance different cancers. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is a novel lncRNA and reported to promote multiple cancer progression. However, biological roles NEAT1 hepatocellular carcinoma (HCC) not cleared nowadays. In present research, level was found be upregulated HCC by The Cancer Genome Atlas. addition, expression negatively correlated with survival rate...
Timely lysosome escape is of paramount importance for endocytosed nanomedicines to avoid premature degradation under the acidic and hydrolytic conditions in lysosomes. Herein, we report an exciting finding that phenylboronic acid (PBA) modification can greatly facilitate cylindrical polymer brushes (CPBs). On basis our experimental results, speculate mechanism associated with specific interactions PBA groups lysosomal membrane proteins hot shock proteins. The featured advantage over known...
Pd-catalyzed cross-coupling reactions have achieved tremendous accomplishments in the past decades. However, C(sp3)-hybridized nucleophiles generally remain as challenging coupling partners due to their sluggish transmetalation compared C(sp2)-hybridized counterparts. While a single-electron-transfer-based strategy using had made significant progress recently, fewer breakthroughs been concerning traditional two-electron mechanism involving nucleophiles. In this report, we present series of...
Nuclear speckles (NSs) are nuclear biomolecular condensates that postulated to form by macromolecular phase separation, although the detailed underlying forces driving NS formation remain elusive. SRRM2 and SON 2 non-redundant scaffold proteins for NSs. How each individual protein governs assembly of network functional relationship between largely unknown. Here, we uncover immiscible multiphases within functionally independent, specifically regulating alternative splicing subsets mRNA...
Tumor cells are known to release large numbers of exosomes containing active substances that participate in cancer progression. Abnormally expressed long noncoding RNAs (lncRNAs) have been confirmed regulate multiple processes associated with tumor However, the mechanism by which lncRNAs affect exosome secretion remains unclear.The underlying mechanisms RNA LINC00511 (LINC00511) regulation multivesicular body (MVB) trafficking, secretion, invadopodia formation, and invasion were determined...
A novel trifluoromethylation of (hetero)arenes and polarized alkenes using simple trifluoroacetic anhydride (TFAA) as the low price CF3 source under photoredox catalysis was developed without additives such bases, hyperstoichiometric oxidant, or auxiliaries. The reaction showed excellent tolerance, including to some important natural products prodrugs, even on gram scale extended ketones. This protocol provides a practical utilization TFAA. Several perfluoroalkylations...
Background: MicroRNAs (miRNAs) have emerged as key players in various human biological processes, including tumorigenesis. Here, we investigated the roles of miR-375 pathogenesis oral squamous cell carcinoma (OSCC). Methods: We performed quantitative real-time PCR (qRT-PCR) to detect expression OSCC tissues and corresponding normal epithelial analyze correlation with metastasis patient’s survival. Then, effects on proliferation, cycle, apoptosis radiosensitivity cells were determined by...
The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications reaction, ipso-alkylation-terminated reactions with β-H-containing reactants not been realized date. Herein, we report alkylation-terminated carbagermatranes (abbreviated as alkyl-Ge) nucleophiles. reactivity alkyl-Ge and alkyl-B(OH)2 in this is discussed. This approach...
MicroRNA (miR)-150-5p has been investigated in many studies, while the role of exosomal miR-150-5p from bone arrow mesenchymal stromal cells (BMSCs) on cerebral ischemia/reperfusion (I/R) injury is not fully explored. This research aims to probe effects BMSCs I/R via regulating B-cell translocation gene 2 (TLR5). Bone marrow stem cell-derived exosomes (BMSCs-Exo) were isolated and identified. The middle artery occlusion (MCAO) rat model was established treated by BMSCs-Exo. Then, functional...