A5029421861- Advanced Optimization Algorithms Research
- Optimization and Variational Analysis
- Sparse and Compressive Sensing Techniques
- Axon Guidance and Neuronal Signaling
- Iterative Methods for Nonlinear Equations
- Cell Adhesion Molecules Research
- Matrix Theory and Algorithms
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Advanced Control Systems Optimization
- Monoclonal and Polyclonal Antibodies Research
- Weed Control and Herbicide Applications
- Plant Stress Responses and Tolerance
- Lipid Membrane Structure and Behavior
- Nanoparticles: synthesis and applications
- Photosynthetic Processes and Mechanisms
- Metaheuristic Optimization Algorithms Research
- Hippo pathway signaling and YAP/TAZ
- Pesticide and Herbicide Environmental Studies
- Genomics, phytochemicals, and oxidative stress
- Allelopathy and phytotoxic interactions
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- Plant-Microbe Interactions and Immunity
- RNA Interference and Gene Delivery
Shanghai Institute of Organic Chemistry
2022-2025
Chinese Academy of Sciences
1996-2025
South China Agricultural University
2022-2024
Jiangxi University of Traditional Chinese Medicine
2009-2024
Soochow University
2012-2024
Ministry of Agriculture and Rural Affairs
2024
Nanjing Agricultural University
2013-2024
Hengyang Normal University
2023
Chengdu University
2020-2023
Huanggang Normal University
2015-2023
Iron oxide nanoparticles (IONPs) are frequently used in biomedical applications, yet their toxic potential is still a major concern. While most studies of biosafety focus on cellular responses after exposure to nanomaterials, little reported analyze reactions the surface as source cytotoxicity. Here we report that different intracellular microenvironment which IONPs located leads contradictive outcomes abilities produce free radicals. We first verified pH-dependent peroxidase-like and...
Malignant gliomas are the most common primary intracranial tumors with a dismal prognosis. Previous investigations by our group demonstrated radiosensitizing effect of silver nanoparticles (AgNPs) on glioma cells in vitro. The goal present study was to evaluate efficacy intratumoral administration AgNPs combination single dose ionizing radiation at clinically relevant MV energies for treatment C6 glioma-bearing rats. (10 or 20 μg/10 μl) were stereotactically administered day 8 after tumor...
Abstract Filopodia, dynamic membrane protrusions driven by polymerization of an actin filament core, can adhere to the extracellular matrix and experience both external cell-generated pulling forces. The role such forces in filopodia adhesion is however insufficiently understood. Here, we study induced overexpression myosin X, typical for cancer cells. lifetime positively correlates with presence IIA filaments at bases. Application tips through attached fibronectin-coated laser-trapped beads...
Nuclear speckles (NSs) are nuclear biomolecular condensates that postulated to form by macromolecular phase separation, although the detailed underlying forces driving NS formation remain elusive. SRRM2 and SON 2 non-redundant scaffold proteins for NSs. How each individual protein governs assembly of network functional relationship between largely unknown. Here, we uncover immiscible multiphases within functionally independent, specifically regulating alternative splicing subsets mRNA...
Abstract The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) rigid glass (RGD-glass), matrix force-dependent signals block Dab2, an clathrin-mediated endocytosis, not recruited to activated integrin-beta3 clusters RGD-glass; however, it integrin-mediated adhesions membranes....
The distribution of methicillin-resistant Staphylococcus aureus (MRSA) clones is dynamic and geographically unique. To understand the changing epidemiology MRSA infections in China, we performed a prospective, multicity surveillance study with molecular typing phenotypic analysis to determine association major prevalent their antimicrobial resistance profiles. A total 517 S. isolates collected between January 2009 March 2012 from six cities China were subjected antibiogram typing, including...
Significance Cell receptors are neither uniformly distributed nor activated across plasma membrane. However, very little is known about how their spatial arrangement affects cellular response to receptor signaling. EphA2 a tyrosine kinase whose activation depends on binding of EphrinA1 ligands the opposing cell, and signaling plays an important role in cancer metastasis. In adherent cells, integrin adhesions key element regulate cell–matrix interactions cell migration. our understanding...
Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it experimentally challenging selectively manipulate receptor clustering without altering other biochemical aspects cellular system. Here, we develop a microfabrication strategy produce substrates displaying mobile and immobile ligands that are separated by roughly 1 µm, thus experience an identical cytoplasmic signaling state, enabling...
Recently identified palmitoylation of PD-L1 is essential for immune regulation. To elucidate the underlying molecular mechanism, we performed giant plasma membrane vesicle (GPMV) experiments, μs-scale all-atom dynamics (MD) simulations, fluorescence resonance energy transfer (FRET) and killing experiments. GPMV experiments indicated that enhanced its lipid raft affinity. MD simulations revealed dramatically different orientation states in liquid-ordered (Lo, raft) compared to...
In open economy, development of foreign trade greatly impacts GDP growth. Adopt modern testing methods like unit root, timeseries cointegration analysis and error correction model for researching the causalities between including total export import with collected 28year statistical data east China from 1981 to 2008, growth China. The result suggests that there exist long term or short termcausality as well export, is reason growth, but no evidence can prove exists stationary causality GDP....
Network security is a complex and systematic project. The intrusion detection system the first line of defense against network security. Snort famous in field open source software. It widely used prevention domain world. In this paper, we explain how implements detection, which includes building compiling environment analysizing work-flow rule tree. This paper will provide valuable reference for study Snort.
The reconstitution of Nipah virus fusion activation provides new insights into the dynamics viral entry glycoproteins.
Abstract As a reducing substance, ascorbic acid functioned well in abiotic and biotic stress. However, the regulatory mechanism of drought resistance is rarely known pak choi. Here we found gene BcSRC2 containing C2 domain that responds to ABA signal regulation Silencing reduces content In Arabidopsis, overexpression promotes accumulation increases tolerance. Meanwhile, transcriptome analysis between WT BcSRC2-overexpressing choi suggests acid-related genes are regulated. interacts with...
Epidermal growth factor receptor (EGFR) is overexpressed in a variety of human malignancies, including pancreatic cancer, breast colon and non-small cell lung cancer. Overexpression EGFR predictive marker therapeutic response several lines evidence suggest that an excellent target for tumor therapy. However, the effective antitumor capacity EGFR-specific T cells against EGFR-overexpressing has not been fully elucidated. In our previous study, we identified anti-EGFR single-chain variable...