A5049770875- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Sirtuins and Resveratrol in Medicine
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Photodynamic Therapy Research Studies
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Advanced Nanomaterials in Catalysis
- Histone Deacetylase Inhibitors Research
- Luminescence and Fluorescent Materials
- Micro and Nano Robotics
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Luminescence Properties of Advanced Materials
- Advanced Drug Delivery Systems
South China University of Technology
2017-2025
Guangzhou Medical University
2020-2025
Guangzhou First People's Hospital
2020-2025
Shanghai Children's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Peking University
2014-2022
Shanghai Pulmonary Hospital
2018-2021
Tongji University
2018-2021
University of Shanghai for Science and Technology
2020
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2020
Significance Beyond its canonical functions in processes such as cell-cycle arrest, apoptosis, and senescence, the tumor suppressor p53 has been increasingly implicated metabolism. Here, vitro vivo studies establish a role for gluconeogenesis through previously unidentified mechanism involving ( i ) direct activation of gene encoding NAD-dependent deacetylase sirtuin 6 (SIRT6), ii SIRT6-dependent deacetylation nuclear exclusion forkhead box protein O1 (FoxO1), iii down-regulation...
Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although autophagy regulation machinery has been widely studied, key epigenetic control still remains unknown. Here we report that methyltransferase EZH2 (enhancer zeste 2 polycomb repressive complex subunit) epigenetically represses several negative regulators MTOR (mechanistic target rapamycin [serine/threonine kinase]) pathway, such as TSC2, RHOA, DEPTOR, FKBP11, RGS16 GPI....
SIRT7 plays a critical role in dissembling and deactivating ATM when DNA damage repair is completed.
Drug delivery systems with remotely controlled drug release capability are rather attractive options for cancer therapy. Herein, a reactive oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NPCe6/DOX was explored to realize by light-activated size shrinkage. The encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) self-assembled from an innovative ROS-sensitive polymer TK-PPE the assistance of amphiphilic copolymer poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL). Under 660...
The simple integration of chemotherapeutic drugs and photosensitizers (PSs) into the same nanocarriers only achieves a combination chemo-photodynamic therapy but may not confer synergistic effects.The boosted intracellular release during photodynamic (PDT) process is necessary to achieve cascade amplified therapeutic effects therapy.Methods: In this study, we explored an innovative hyperbranched polyphosphate (RHPPE) containing singlet oxygen (SO)-labile crosslinker boost drug PDT...
Effectively activating macrophages that can engulf cancer cells is a promising immunotherapeutic strategy but remains major challenge due to the expression of "self" signals (e.g., CD47 molecules) by tumor prevent phagocytosis. Herein, we explored siRNA-assisted assembly for simultaneous delivery siRNA and mitoxantrone hydrochloride (MTO·2HCl) via PLGA-based nanoparticles. The suppressed signal silencing gene, while MTO induced surface exposure calreticulin (CRT) provide an "eat-me" signal....
Immunotherapy has revolutionized the therapeutic modalities of cancer treatment but is severely limited by a low objective response rate and risk immune-related side effects. Herein, an injectable supramolecular hydrogel developed for local delivery
Abstract Developing precise nanomedicines to improve the transport of anticancer drugs into tumor tissue and final action site remains a critical challenge. Here, we present bioorthogonal in situ assembly strategy for prolonged retention within areas act as drug depots. After extravasating site, slightly acidic microenvironment induces exposure cysteine on nanoparticle surface, which subsequently undergoes reaction with 2-cyanobenzothiazole group another neighboring nanoparticle, enabling...
5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination remain unclear.Here, we report that NAD + -dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due 5-FU exposure rendering colorectal cancer cells sensitive radiation.We found SIRT7 downregulation was mediated via Tat-binding Protein 1 (TBP1) proteasome-dependent pathway.Specifically, TBP1 dephosphorylated at tyrosine 381...
Abstract Genomic instability is an underlying hallmark of cancer and closely associated with defects in DNA damage repair (DDR). Chromatin relaxation a prerequisite for DDR, but how chromatin accessibility regulated remains elusive. Here we report that the histone deacetylase SIRT6 coordinates remodeler CHD4 to promote response damage. Upon damage, rapidly translocates sites, where it interacts recruits CHD4. Once at displaces heterochromatin protein 1 (HP1) from H3 lysine 9 trimethylation...
Linker histone H1 has a key role in maintaining higher order chromatin structure and genome stability, but how functions these processes is elusive. Here, we report that acetylation of lysine 85 (K85) within the globular domain critical post-translational modification regulates organization. H1K85 dynamically acetylated by acetyltransferase PCAF response to DNA damage, this effect counterbalanced deacetylase HDAC1. Notably, an acetylation-mimic mutation (H1K85Q) alters binding nucleosome...
Small interfering RNA (siRNA) shows excellent pharmaceutical prospects in treating diverse life-threatening diseases. Photodynamic therapy (PDT) is a clinically employed noninvasive treatment method that can trigger selective damage toward targeted tissue and cells. However, insufficient delivery of siRNA photosensitizer to cancer cells remarkably hindered the application PDT cancer. In this study, unique reactive oxygen species (ROS)-activatable polyplex, which consists PEGylated cationic...
The passive diffusion performance of nanocarriers results in inefficient drug transport across multiple biological barriers and consequently cancer therapy failure. Here, a magnetically driven amoeba-like nanorobot (amNR) is presented for whole-process active transport. amNR actively extravasated from blood vessels penetrated into deep tumor tissue through deformation effect. Moreover, the acidic microenvironment uncovers masked targeting ligand to achieve cell uptake. Furthermore, rapidly...
The abnormal activation of epidermal growth factor receptor (EGFR) drives the development non-small cell lung cancer (NSCLC). EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with who have an EGFR mutation. However, free administration inadequate response vivo, only ∼3% demonstrating a complete clinical response. Consequently, we designed biomimetic nanoparticle (CMNP@Osi) comprising polymeric core...
Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in regulation various cellular processes and resisting stresses, such as hypoxia, low glucose levels, DNA damage. Interestingly, SIRT7 linked to control glycolysis, suggesting role metabolism. Given important roles SIRT7, it critical clarify how activity potentially regulated. It has been reported that some transcriptional post-transcriptional regulatory mechanisms are involved. However, little...
Rationale: PEGylation of nanocarriers could extend blood circulation time and enhance tumor accumulation via the enhanced permeability retention (EPR) effect.Unfortunately, PEG moiety suppresses cell internalization nanocarriers, resulting in limited therapeutic efficiency (known as dilemma).Designing stimuli-responsive shell-detachable which detach corona from desired tissues response to local environment, is an appealing approach overcome dilemma, but nanocarrier applications are also by a...
With the rapid growth in wearable electronics sensing devices, flexible devices that monitor human body have shown great promise personalized healthcare. In study, high-quality GaN pn junction microwire arrays with different aspect ratios and large-area uniformity are fabricated through an easy, repeatable fabrication process. The piezoelectric coefficient (d33 ) of increases from 7.23 to 14.46 pm V-1 increasing ratio, which is several times higher than bulk material. Furthermore,...