A5100642240- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Ferroptosis and cancer prognosis
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Respiratory and Cough-Related Research
- Inflammasome and immune disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Acupuncture Treatment Research Studies
- Cancer, Lipids, and Metabolism
- Vitamin C and Antioxidants Research
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Diabetic Foot Ulcer Assessment and Management
- NF-κB Signaling Pathways
- Traditional Chinese Medicine Analysis
- Cell death mechanisms and regulation
- Vitamin D Research Studies
- Ginger and Zingiberaceae research
- Mechanisms of cancer metastasis
- Air Quality and Health Impacts
- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- Carbohydrate Chemistry and Synthesis
First Affiliated Hospital of Zhengzhou University
2025
Chinese PLA General Hospital
2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2024
Chinese People's Liberation Army
2024
Community Health Center
2018-2022
Shanghai Medical Information Center
2015-2020
Dalian Medical University
2019
Shenzhen University Health Science Center
2019
Qilu Hospital of Shandong University
2012
Institute of Nutrition, Metabolism and Diabetes
2012
Asthma is a chronic airway inflammatory disease and acupuncture frequently used in patients suffering from asthma clinic. However, the regulatory mechanism of treatment not fully elucidated. We sought to investigate effectiveness on associated mechanism. An ovalbumin (OVA)-induced mouse model was established effect hyperresponsiveness (AHR), mucus hypersecretion inflammation assessed. Tandem mass tag (TMT)-based quantitative proteomics analysis lung tissue bioinformatics were performed. Our...
Abstract Refractory periapical periodontitis, which is a persistent infection after root canal treatment, still has no effective treatment. Its most common pathogen Enterococcus faecalis . Here, the precursor of phytosteroids, dioscin, introduced to fight against inflammation induced by The findings suggest that dioscin inhibits nuclear transport NF‐κB and expression reactive oxygen species (ROS) lipoteichoic acid from decrease in mRNA protein levels NLRP3, Caspase‐1, IL‐1β observed treated...
Previous studies have indicated that allergens such as house dust mites (HDM) in the environment can induce allergic asthma. Ferroptosis is a newly discovered form of regulatory cell death characterized by aberrant lipid peroxidation and accumulation reactive oxygen species (ROS) cells. However, whether ferroptosis participates pathological process asthma remains to be elucidated. The present study used HDM-induced mouse model determine effect HDM exposure on its underlying mechanisms....
Objective: Polygonum multiflorum Thunb. (PM) is a commonly used tonic herb known to cause idiosyncratic drug-induced liver injury (IDILI). This study explored the detoxification effects and potential mechanisms of action Paeoniae Radix Alba (PRA) on PM-induced IDILI. Methods: Network pharmacology analysis was utilized predict related targets "PRA-PM-innate immunity.” A non-hepatotoxic lipopolysaccharide (LPS) IDILI model evaluate PRA by measuring function indicators, pathological...
Abstract Foot ulcerations in patients with diabetes are common and severe, typically caused by infection chronic inflammation. Poor blood circulation neuropathy impair the body's ability to heal wounds effectively, creating a conducive environment for ulcers. Excessive reactive oxygen species contribute ulcer development damaging cellular structures hindering wound healing. The administration of antioxidants can protect cells from oxidative damage promote recovery. Antioxidants such as...
Acupuncture is an effective therapeutic method in asthma treatment traditional Chinese medicine. Here, we evaluated the effect of acupuncture on airway hyperresponsiveness (AHR) and associated inflammatory changes as well Th17 Treg activity ovalbumin- (OVA-) induced experimental asthma. Our results revealed that significantly inhibited AHR, lung inflammation, mucus secretion mice. Furthermore, a decrease lymphocytes eosinophils neutrophils was observed bronchoalveolar lavage fluid (BALF)...
Background Bronchial asthma is a chronic airway inflammatory disease which has three main pathological features: hyperresponsiveness (AHR), remodelling, and inflammation. Acupuncture known to be an effective integrative medical therapy that been used in the treatment of several diseases, including bronchial asthma. The aim current study was evaluate effects acupuncture on inflammation regulation IL-33/ST2 pathway mouse model Methods murine established by both injection inhalation ovalbumin...
Nucleoside diphosphate kinase 4 (NME4) is abnormally expressed in a variety of cancer types. However, the function NME4 gene non‑small cell lung (NSCLC) remains to be elucidated. In order investigate role NSCLC, present study detected expression Cancer Genome Atlas database, and BEAS‑2B, NCI‑H1299 A549 lines. was significantly overexpressed NSCLC tissues Furthermore, lentivirus‑mediated knockdown vector infection, proliferation, cycle, apoptosis, colony formation MTT assays were conducted...
Drug-induced liver injury (DILI), a type of acute inflammation, has sparked significant concern owing to its unpredictability and severity. Psoraleae Fructus (PF), an edible Chinese herb widely used in traditional medicine (TCM), causes injury. Therefore, the elucidation mechanism underlying PF-induced search for more effective means detoxification using herbal compatibility become urgent issue. This study evaluated hepatoprotective effects Paeoniae Radix Alba (PRA), medicine, on explored mechanisms.
To determine the expression of Bruton's tyrosine kinase (BTK) in refractory periapical periodontitis and analyze relationship between BTK bone resorption periodontitis. The mechanism is also discussed. OneArray Plus microarray was used to screen for genes related Real-time PCR detect tissues. A model established by sealing E.faecalis into pulp rats. establish a LTA infection osteoclasts, destruction during analyzed. results showed that we found 1787 two samples different. After validating...
Background Group 2 innate lymphoid cells (ILC2s) are known to serve important functions in the pathogenesis of allergic airway inflammation. Studies have shown that acupuncture has an anti-inflammatory effect airways. However, how treatment affects immunity, especially with regard function ILC2s ovalbumin (OVA)-induced inflammation, is poorly understood. Methods BALB/c mice were injected and subsequently challenged OVA ± treated manual acupuncture. At end experimental course, lung was...
To observe the effect of Bruton's tyrosine kinase (BTK) on proliferation and differentiation osteoclasts to explore mechanism BTK bone destruction in periapical periodontitis.After RAW264.7 cells induced with 100 ng·L⁻¹ receptor activator for nuclear factor-κB ligand (RANKL) 5 days, osteoclast induction was confirmed by light microscopy, tartrate-resistant acid phosphatase (TRAP) staining, quantitative real-time PCR (RT-qPCR). Then, BTK-small interfering RNA (BTK-siRNA) transfected into...
Abstract Background: Studies have indicated that allergens such as house dust mites (HDM) in the environment could induce allergic asthma. Ferroptosis is a newly discovered regulatory cell death characterized by aberrant lipid peroxidation and accumulation of reactive oxygen species (ROS) cells. However, whether ferroptosis participates pathological progress asthma remains to be elucidated. In this study, we used HDM-induced mouse model determine effect HDM exposure on underlying mechanisms....