A5047692322- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Insect-Plant Interactions and Control
- Chronic Lymphocytic Leukemia Research
- Cell death mechanisms and regulation
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Cell Image Analysis Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Research and Splicing
- Galectins and Cancer Biology
- Advanced Fluorescence Microscopy Techniques
- Ubiquitin and proteasome pathways
- Viral Infections and Outbreaks Research
- Cardiac Fibrosis and Remodeling
First Affiliated Hospital of Zhengzhou University
2024
Xiamen University
2016-2023
South China Agricultural University
2014-2015
Synonymous codon usage bias (SCUB) is an inevitable phenomenon in organismic taxa, generally referring to differences the occurrence frequency of codons across different species or within genome same species. SCUB happens various degrees under pressure from nature selection, mutation and other factors ways. It also attaches great significance gene expression evolution, however, a systematic investigation towards Bombyx mori (B. mori) has not been reported yet. Moreover, it still indistinct...
Abstract The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays crucial role in execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify molecular chaperone Hsp90 as novel MLKL-interacting protein. We show associates with required for stability. Moreover, find also regulates stability upstream RIP3 kinase. Interference function 17AAG inhibitor...
The analysis of codon usage is a good way to understand the genetic and evolutionary characteristics an organism. However, there are only few reports related with domesticated silkworm, Bombyx mori (B. mori). Hence, B. was analyzed here reveal constraint factors it could be helpful improve bioreactor based on mori. A total 1,097 annotated mRNA sequences from were analyzed, revealing weak bias. It also shows that gene expression level GC content, amino acids higher general average...
Abstract Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective clinical therapies to block the metastatic cascade. A need develop novel specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that Salmonella YB1, an engineered oxygen-sensitive strain, potently inhibits a broad range cancers. This process requires both IFN-γ and NK cells, as absence greatly reduces, whilst depletion cells in vivo completely abolishes,...
Background Oncolytic viruses (OVs) are capable to inflame the tumor microenvironment (TME) and elicit infiltrating tumor-specific T cell responses. However, OV treatment negatively alters cancer-immune set point in tumors attenuate antitumor immune response, which suggests necessity of dissecting landscape virus-treated developing novel strategies maximize potential OVs. The aim this study is investigate effect single-chain variable fragment (scFv)-armed OVs targeting PD-1 on TME, ultimately...
Background and Aims: NASH-HCC is inherently resistant to immune checkpoint blockade, but its tumor microenvironment largely unknown. Approach Results: We applied the imaging mass cytometry construct a spatially resolved single-cell atlas from formalin-fixed paraffin-embedded tissue sections patients with NASH-HCC, virus-HCC (HBV-HCC HCV-HCC), healthy donors. Based on 35 biomarkers, over 750,000 individual cells were categorized into 13 distinct cell types, together expression of key...
Aquilaria sinensis (Lour.) Gilg is an important medicinal woody plant producing agarwood, which widely used in traditional Chinese medicine. High-throughput sequencing of chloroplast (cp) genomes enhanced the understanding about evolutionary relationships within families. In this study, we determined complete cp genome sequences for A. sinensis. The size was 159,565 bp. This included a large single-copy region 87,482 bp, small 19,857 and pair inverted repeats (IRa IRb) 26,113 bp each. GC...
T cell exhaustion is important to protect the host from immunopathology during chronic viral infection, but it also impairs anti-tumor immunity (1-5). A fundamental unresolved question whether and how determined at onset of TCR signaling (6-8). Here we report an unexpected role Themis, a TCR-proximal molecule (9), in exhaustion. Chronic infection mice usually leads survival host. Surprisingly, Themis T-cell conditional knockout died severe CD8(+)-dependent lung showing Themis' importance...
Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature B or T lymphocytes. Extensive studies have suggested involvement angiogenesis signaling in ALL progression and resistance to treatment. Thus, targeting with anti-angiogenic drugs may be promising approach for In this study, we investigated the effectiveness Apatinib, novel receptor tyrosine kinase inhibitor selectively VEGFR-2 cells. cell lines were treated different...
To investigate the clinical features and prognosis of childhood acute lymphoblastic leukemia (ALL) with
Major histocompatibility complex (MHC) class II-reactive CD8+ T cells are found in humans and animals, but little is known about their identity, development, function. In this study, we discover a group of reactive to both MHC I II molecules II-deficient mice. We clone cell receptors (TCRs) analyze development wild-type thymocytes bearing those TCRs purged by negative selection. the absence II, they develop into mature cells. When encountering periphery, undergo robust activation...
Abstract SHP-1 (Src homology region 2 domain-containing phosphatase 1) is a well-known negative regulator of T cells, whereas its close homolog SHP-2 the long-recognized main signaling mediator PD-1 inhibitory pathway. However, recent studies have challenged requirement in signaling, and follow-up further questioned alternative idea that may replace absence. In this study, we systematically investigate role alone or jointly with CD8+ cells series gene knockout mice. We show although...
Molecular pathways controlling emigration of mature thymocytes from thymus to the periphery remain incompletely understood. Here, we show that T cell–specific ablation glycogen synthase kinase 3 (GSK3) led severely impaired thymic egress. In absence GSK3, β-catenin accumulated in cytoplasm, where it associated with and activated Akt, leading phosphorylation degradation Foxo1 downregulation Klf2 S1P1 expression, thereby preventing thymocytes. A cytoplasmic membrane-localized excluded nucleus...