A5023709490- Spinal Cord Injury Research
- Nerve injury and regeneration
- RNA Research and Splicing
- Animal Virus Infections Studies
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve Injury and Rehabilitation
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Advanced Fluorescence Microscopy Techniques
- Virus-based gene therapy research
- Tissue Engineering and Regenerative Medicine
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- SARS-CoV-2 and COVID-19 Research
- Silicon Nanostructures and Photoluminescence
King's College London
2022
University of Bucharest
2014-2021
University of Hong Kong
2017-2021
Abstract Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective clinical therapies to block the metastatic cascade. A need develop novel specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that Salmonella YB1, an engineered oxygen-sensitive strain, potently inhibits a broad range cancers. This process requires both IFN-γ and NK cells, as absence greatly reduces, whilst depletion cells in vivo completely abolishes,...
Abstract Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical role in preventing inflammation resolution by blocking the conversion pro-inflammatory immune cells to pro-repair phenotype rodent models SCI. We demonstrate enzymatic digestion CSPG glycosaminoglycans enhances cell clearance reduces protein gene expression profiles at key time points. Analysis...
When spinal roots are torn off from the cord, both peripheral and central nervous system get damaged. As motoneurons lose their axons, they start to die rapidly, whereas target muscles atrophy due denervation. In this kind of complicated injury, different processes need be targeted in search for best treatment strategy. study, we tested glial cell-derived neurotrophic factor (GDNF) fetal lumbar cell transplantation effectiveness prevent motoneuron death muscle after root avulsion delayed...
The Coronavirus Disease 2019 (COVID-19) pandemic is unlikely to abate until sufficient herd immunity built up by either natural infection or vaccination. We previously identified ten linear immunodominant sites on the SARS-CoV-2 spike protein of which four are located within RBD. Therefore, we designed two linkerimmunodominant site (LIS) vaccine candidates composed RBD (RBD-ID) all 10 whole (S-ID). They were administered subcutaneous injection and tested for immunogenicity in vivo protective...
This report is the first research study that aims to explore molecular mechanisms involved in vitro pulmonary cytotoxicity triggered by long-term exposure silicon-based quantum dots (QDs). Human lung fibroblasts (MRC-5 cell line) were exposed 5 µg/mL QDs for weeks and concentration was increased up 40 during next 4 weeks. Cell viability population doubling level calculated based on Trypan blue staining. The expression levels of proteins established Western blotting telomeres’ length...
There is currently very little research regarding the dynamics of subcellular degenerative events that occur in central nervous system response to injury. To date, multi-photon excitation has been primarily used for imaging applications; however, it recently selectively disrupt neural structures living animals. However, understanding complicated processes and essential underlying molecular pathways involved these dynamic necessary studying process promotes neuronal regeneration. In this...