A5100355713- Spinal Cord Injury Research
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Hepatitis B Virus Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pregnancy and Medication Impact
- Tryptophan and brain disorders
- Molecular Sensors and Ion Detection
- Endoplasmic Reticulum Stress and Disease
- Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Ubiquitin and proteasome pathways
- Aortic Disease and Treatment Approaches
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Mesenchymal stem cell research
- Metal-Organic Frameworks: Synthesis and Applications
The University of Texas MD Anderson Cancer Center
2021-2025
Florida State University
2011-2025
Shanghai Medical College of Fudan University
2025
Wuhan University
2025
Northeast Agricultural University
2024
Affiliated Hospital of Guizhou Medical University
2020-2024
Guiyang Medical University
2020-2024
The University of Texas Health Science Center at Houston
2024
Cleveland Clinic
2024
Shenzhen University
2024
Abstract Dysregulation of R-loop homeostasis is closely related to various human diseases, including cancer. However, the causality aberrant R-loops in tumor progression remains unclear. In this study, using single-cell RNA-sequencing datasets from lung adenocarcinoma (LUAD), we constructed an scoring model characterize state according identified regulators EGFR mutations, tissue origins, and TNM stage. We then evaluated relationships score with microenvironment (TME) treatment response....
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) through direct lysis of infected lung epithelial cells, which releases damage-associated molecular patterns and induces a pro-inflammatory cytokine milieu causing systemic inflammation. Anti-viral anti-inflammatory agents have shown limited therapeutic efficacy. Soluble CD24 (CD24Fc) blunts the broad inflammatory response induced by via binding to extracellular high...
A dual-dyes-encapsulated white-light emitting naphthalene-based Zr-MOF was synthesized and employed as fluorescent sensor for detecting inorganic ions with quenching or colorimetric detection mode.
While over half of all spinal cord injuries (SCIs) occur in the cervical region, majority preclinical studies have focused on models thoracic injury. However, these two levels are anatomically distinct-with region possessing a greater vascular supply, grey-white matter ratio and sympathetic outflow relative to region. As such, there exists significant knowledge gap secondary pathology at following SCI. In this study, we characterized systemic plasma markers inflammation time (1, 3, 7, 14, 56...
Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously identified lysyl oxidase (LOX) olfactomedin like-3 (OLFML3) as essential macrophage chemokines, respectively, GBM. Here, single-cell transcriptomics multiplex sequential immunofluorescence followed by functional studies demonstrate that negatively correlate with the GBM microenvironment. LOX inhibition PTEN-deficient...
Following spinal cord injury (SCI) there are drastic changes that occur in the microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal barrier disruption. Vascular growth factor-A (VEGF-A) is a pleiotropic factor recognized for its pro-angiogenic properties; however, VEGF has recently been shown to provide neuroprotection. We hypothesized delivery of AdV-ZFP-VEGF – an adenovirally delivered bio-engineered zinc-finger transcription promotes endogenous VEGF-A...
Phagocytosis involves the engulfment and enzymatic degradation of particulate objects by phagocytes in a compartment called phagosome. The mechanisms for natural phagocytic such as proteins peptides are not well understood. To explore this, we developed novel method using microparticles made and/or poly(N-isopropylacrylamide) (PNIPAM) via microfabrication. These were fed to phagocytes, presence fluorescently labeled fragments phagosome-derived vesicles (PDVs) was characterized. Using...
Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Despite available antiviral strategies, the therapeutic eradication HBV from infected cells remains challenging. Recent studies have highlighted role dual-specificity tyrosine-regulated kinases (DYRKs) in innate immunity against viruses and HCC; however, function DYRK4 unknown. Here, we report that efficiently inhibited replication both vitro vivo. Mechanistically, demonstrate direct...
Abstract Background: Gastric cancer exhibits diverse malignant cell states that contribute to intratumor heterogeneity (ITH), a fundamental factor drive tumor progression, metastasis, and treatment resistance. While previous single-cell RNA sequencing (scRNA-seq) studies have provided novel insights into ITH in gastric cancer, they are often constrained by small sample sizes limited transcriptional coverage. Methods: In this study, we curated, annotated, integrated scRNA-seq datasets from 21...
Although the increased expression of members chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to spinal cord, a complete picture cellular origins and function this NG2 has yet be made. Using cord (SCI) mouse model, we describe that some infiltrated bone marrow-derived macrophages (BMDMΦ) are early contributors NG2/CSPG4 secretion SCI. We demonstrate for first time lesion-related form debris generated from damaged myelin...
Introduction Spinal cord injury (SCI) is a severe central nervous system that leads to significant sensory and motor impairment. Copper, an essential trace element in the human body, plays vital role various biological functions strictly regulated by copper chaperones transporters. Cuproptosis, novel type of metal ion-induced cell death, distinct from iron deprivation. Copper deprivation closely associated with mitochondrial metabolism mediated protein fatty acid acylation. Methods In this...
The outbreak of a novel coronavirus (COVID-19) with symptoms that mimic bronchitis and other chest infections has created need for quick diagnosis to prevent disease spread. Traditionally, computed tomography (CT) been used as the primary method identify infection staging virus. While effective, repeated use ionizing radiation, particularly in susceptible patient populations, can add risk is monitored through full recovery. Sonography may be viable alternative monitoring COVID-19. In...
Spinal cord injury (SCI) is associated with an increased susceptibility to infections, such as pneumonia, which the leading cause of death in these patients. This phenomenon referred SCI immune deficiency syndrome (SCI-IDS), and has been shown be more prevalent after high-level transection preclinical models. Despite high prevalence contusion SCIs, effects this etiology have not studied context SCI-IDS. Compared involve a complete loss supraspinal input lead disinhibition spinally-generated...
Spinal cord injury (SCI) triggers a complex cascade of events, including myelin loss, neuronal damage, neuroinflammation, and the accumulation damaged cells debris at site. Infiltrating bone marrow derived macrophages (BMDMϕ) migrate to epicenter SCI lesion, where they engulf cell abundant become pro-inflammatory foamy (foamy Mϕ), participate facilitate progression SCI. This study aimed elucidate cellular molecular mechanisms underlying functional changes in Mϕ their potential implications...
Spinal cord injuries (SCI) cause serious neurological impairment and psychological, economic, social consequences for patients their families. Clinically, more than 50% of SCI affect the cervical spine1. As a consequence primary injury, cascade secondary mechanisms including inflammation, apoptosis, demyelination occur finally leading to tissue scarring development intramedullary cavities2,3. Both represent physical chemical barriers cell transplantation, integration, regeneration....
Transplantation of fetal spinal cord cells (FSCC) can promote regeneration injured cord, while Schwann (SC) and some growth factors have a similar effect. However, the synergistic effects optimal combination these modalities not yet been evaluated. In current study, efficiency cell therapy FSCC and/or SC, with/without (nerve factor [NGF] brain-derived neurotrophic [BDNF]) was examined, with aim establishing an optimized protocol for injury.One hundred twenty adult rats were randomly divided...