A5039435227- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Metal-Organic Frameworks: Synthesis and Applications
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Single-cell and spatial transcriptomics
- Nuclear Receptors and Signaling
- MXene and MAX Phase Materials
- Advanced Glycation End Products research
- Biological Stains and Phytochemicals
Cleveland Clinic Lerner College of Medicine
2025
Cleveland Clinic
2024-2025
Neurological Surgery
2022-2024
Northwestern University
2022-2024
Boston Children's Museum
2023
Boston Children's Hospital
2023
The University of Texas MD Anderson Cancer Center
2023
North Dakota State University
2017-2021
Dakota State University
2017-2020
China Pharmaceutical University
2016-2019
Glioblastoma (GBM) is one of the most aggressive tumors in adult central nervous system. We previously revealed that circadian regulation glioma stem cells (GSCs) affects GBM hallmarks immunosuppression and GSC maintenance a paracrine autocrine manner. Here, we expand mechanism involved angiogenesis, another critical hallmark, as potential basis underlying CLOCK's pro-tumor effect GBM. Mechanistically, CLOCK-directed olfactomedin like 3 (OLFML3) expression results hypoxia-inducible factor...
Abstract Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs migration lactate dehydrogenase inhibitor stiripentol emerges as the top hit. Combined profiling functional studies demonstrate A (LDHA)-directed extracellular signal-regulated kinase (ERK) pathway activates yes-associated protein 1 (YAP1)/ signal transducer...
Abstract The symbiotic interactions between cancer stem cells and the tumor microenvironment (TME) are critical for progression. However, molecular mechanism underlying this symbiosis in glioblastoma (GBM) remains enigmatic. Here, we show that circadian locomotor output cycles kaput (CLOCK) its heterodimeric partner brain muscle ARNT-like 1 (BMAL1) glioma (GSC) drive immunosuppression GBM. Integrated analyses of data from transcriptome profiling, single-cell RNA sequencing, TCGA datasets,...
Glioblastoma (GBM) is a hypoxic and "immune-cold" tumor containing rich stromal signaling molecules cell populations, such as proteases immunosuppressive tumor-associated macrophages (TAMs). Here, we seek to profile characterize the potential that may contribute GBM immunosuppression. Legumain (LGMN) emerges key protease highly enriched in TAMs transcriptionally upregulated by hypoxia-inducible factor 1-alpha (HIF1α). Functionally, increased LGMN promotes TAM polarization via activating...
The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-related diseases in traditional Chinese medicine. In recent years, celastrol (a natural compound from the root of vine) has attracted great interest its potential anticancer activities. free radical nitric oxide (NO) known to play a critical role colorectal cancer growth by promoting tumour angiogenesis. However, how influences NO pathway and mechanism against largely unknown. this study, we...
We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation 8-HOA from COX-2-catalyzed peroxidation, which turn inhibits cell growth and migration. However, delivery naked remains a formidable challenge due to its "off-target" effect. In this study, we employed RNA nanotechnology for specific D5D-siRNA xenograft colon tumors using 3WJ nanoparticles. When targeting module, i.e., EpCAM aptamer, was...
Abstract GRS is a drug combination of three active components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula ShengMai preparations, widely used traditional Chinese medicine for treatment cardiovascular diseases in clinic. The present study explores cardioprotective effects on myocardial ischemia/reperfusion (MI/R) injury compared with preparations investigates underlying mechanisms. significantly attenuated MI/R exhibited similar efficacy as...
Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydroxyoctanoic (8-HOA), resulting in inhibition of colon and pancreatic cancers. However, effect siRNA on lung cancer is still unknown. In this study, incorporating epithelial cell adhesion molecule (EpCAM) aptamer validated into innovative three-way...
Major advances in cancer control can be greatly aided by early diagnosis and effective treatment its pre-invasive state. Lung (small cell non-small cell) is a leading cause of cancer-related deaths among both men women around the world. A lot research attention has been directed toward diagnosing treating lung cancer. common method based on COX-2 (cyclooxygenase-2) inhibitors. This because commonly overexpressed also abundance enzymatic product prostaglandin E2 (PGE2). Instead using...
Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously identified lysyl oxidase (LOX) olfactomedin like-3 (OLFML3) as essential macrophage chemokines, respectively, GBM. Here, single-cell transcriptomics multiplex sequential immunofluorescence followed by functional studies demonstrate that negatively correlate with the GBM microenvironment. LOX inhibition PTEN-deficient...
Tumor-associated macrophages (TAMs) are the most prominent immune cell population in glioblastoma (GBM) tumor microenvironment (TME) and play critical roles promoting progression immunosuppression. Here we identified that TAM-derived legumain (LGMN) exhibited a dual role regulating biology of TAMs GBM cells. LGMN promoted macrophage infiltration cell-autonomous manner by activating GSK3b-STAT3 pathway. Moreover, activated integrin aV-AKT-P65 signaling to drive proliferation survival....
Background and purpose Hemorrhagic transformation ( HT ) is a major complication of acute ischaemic stroke that potentially related to clinical deterioration. The objective this study was assess whether chronic hyperglycemia predictive factor in patients with anterior stroke. Methods Patients were included study. Hemoglobin A1c (HbA1c) measured the morning after hospitalization. detected by computed tomography scans or gradient echo magnetic resonance imaging performed 4 (±2) days onset....
YiQiFuMai Powder Injection (YQFM) is widely used in clinical practice for the treatment of heart failure (HF). However, its functional molecular mechanism remains to be fully uncovered. Our present study aimed elucidate impact YQFM and underlying mechanisms on coronary artery ligation (CAL)-induced HF. results exhibited that significantly mitigated CAL-induced HF via meliorating left ventricular contractile function reducing serum content creatine kinase MB (CK-MB), aspartate...
Abstract Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs migration lactate dehydrogenase (LDH) inhibitor stiripentol (an FDA-approved anti-seizure drug for Dravet Syndrome) emerges as the top hit. Combined profiling functional studies demonstrate LDHA-directed ERK pathway activates YAP1/STAT3 transcriptional co-activators...
Major advances in cancer control can be greatly aided by early diagnosis and effective treatment its pre-invasive state. Lung (small cell non-small cell) is a leading cause of cancer-related death among both men women around the world. A lot research attention has been attracted to diagnosing treating lung cancer. common method based on COX-2 (Cyclooxygenase-2) inhibitors. This because commonly over expressed also abundance enzymatic product Prostaglandin E2 (PGE2). Instead using traditional...