A5100737903- Virus-based gene therapy research
- CAR-T cell therapy research
- Gut microbiota and health
- Cancer Research and Treatments
- Phytochemicals and Antioxidant Activities
- Fermentation and Sensory Analysis
- Cytomegalovirus and herpesvirus research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant nutrient uptake and metabolism
- Plant biochemistry and biosynthesis
- Immune cells in cancer
- Ecology and Vegetation Dynamics Studies
- Plant Molecular Biology Research
- Extracellular vesicles in disease
- Plant Gene Expression Analysis
- Liver Disease Diagnosis and Treatment
- Identification and Quantification in Food
- Alcohol Consumption and Health Effects
- Zeolite Catalysis and Synthesis
- Ginseng Biological Effects and Applications
- Leaf Properties and Growth Measurement
- Mesoporous Materials and Catalysis
- Catalytic Processes in Materials Science
- Veterinary Orthopedics and Neurology
- Remote Sensing and Land Use
China Tobacco
2022-2025
Xiamen University
2020-2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Institute of Process Engineering
2024
Tianjin University of Science and Technology
2019-2023
Wuhan University
2021-2023
Southern Medical University
2019-2023
Dongguan People’s Hospital
2006-2023
Beijing Forestry University
2022
Background Oncolytic viruses (OVs) are capable to inflame the tumor microenvironment (TME) and elicit infiltrating tumor-specific T cell responses. However, OV treatment negatively alters cancer-immune set point in tumors attenuate antitumor immune response, which suggests necessity of dissecting landscape virus-treated developing novel strategies maximize potential OVs. The aim this study is investigate effect single-chain variable fragment (scFv)-armed OVs targeting PD-1 on TME, ultimately...
Oncolytic virotherapy can lead to systemic antitumor immunity, but the therapeutic potential of oncolytic viruses in humans is limited due their insufficient ability overcome immunosuppressive tumor microenvironment (TME). Here, we showed that locoregional upregulated expression PD-L1 TME, which was mediated by virus-induced type I and II IFNs. To explore PD-1/PD-L1 signaling as a direct target tissue, developed novel immunotherapeutic herpes simplex virus (HSV), OVH-aMPD-1, expressed...
Vinegar extract inhibited alcohol-induced ROS generation and inflammation. modulated gut microbiota improved intestinal homeostasis, which could be used as a novel manipulator against liver damage.
ZSM-5 zeolite is a kind of high-value-added porous aluminosilicate zeolite. The use the coal gasification slag utilization process by-product desilication liquid as silicon raw material to replace current materials such water glass will help reduce production costs and achieve high-value solid waste. zeolites for volatile organic compounds (VOCs) adsorption were prepared by one-step hydrothermal method using solution from main source sodium source. effects crystallization reaction time,...
Abstract Stomata play important roles in gas and water exchange leaves. The morphological features of stomata pavement cells are highly plastic regulated during development. However, it is very laborious time-consuming to collect accurate quantitative data from the leaf surface by manual phenotyping. Here, we introduce LeafNet, a tool that automatically localizes stomata, segments (to prepare them for quantification), reports multiple parameters variety epidermal images, especially...
Nuclear Factor Y (NF-Y) represents a group of transcription factors commonly present in higher eukaryotes, typically consisting three subunits: NF-YA, NF-YB, and NF-YC. They play crucial roles the embryonic development, photosynthesis, flowering, abiotic stress responses, other essential processes plants. To better understand genome-wide NF-Y domain-containing proteins, protein physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure,...
Abstract Extracellular vesicles (EVs) mediate intercellular communication via transferring proteins and other biological molecules have been recently investigated as biomarkers of disease. Sensitive specific are required for lung cancer diagnosis prognosis. The present study screens abnormal EV in non‐small cell (NSCLC) using a quantitative proteomics strategy involving LC‐MS/MS to identify ideal NSCLC diagnosis. EVs enriched from the sera early advanced patients healthy controls culture...
Rosa rugosa is a famous Chinese traditional flower with high ornamental value and well environmental adapt ability. The cultivation of new colorful germplasms to improve monotonous color could promote its landscape application. However, the mechanism formation in R. remains unclear. In this study, combined analyses chemical transcriptome were performed representative colors. Among identified anthocyanins, cyanidin 3,5- O -diglucoside (Cy3G5G) peonidin (Pn3G5G) two dominant anthocyanins...
Vinegar is used as fermented condiment and functional food worldwide. contains many nutrients bioactive components, which exhibits health benefits. In this study, the potential effects of Shanxi aged vinegar (SAV) on gut microbiome metabolome were explored in normal mice. The levels inflammatory factors significantly decreased SAV-treated Immunoglobulin, NK cells CD20 expression increased after SAV administration. addition, intake altered microbiota structure by up-regulating Verrucomicrobia,
Zhenjiang aromatic vinegar (ZAV) is a kind of traditional fermented food worldwide. In this study, the changes physicochemical properties, total phenolic content (TPC), flavonoid (TFC), and antioxidant activity (TAA) were evaluated during brewing process ZAV. addition, correlation between compound contents activities was investigated aging (AP) The results showed that acids, non-volatile amino nitrogen increased gradually process. Reducing sugar decreased sharply at early fermentation stage...
Wolfberry (Lycium barbarum L.) is a nutritious and medicinal fruit, deeply processed products of wolfberry needs to be improved. In this study, nutrition, bioactive compounds, hepaprotective activity were explored in vinegar (WFV). The contents nutrients including total sugar protein WFV samples 2.46 0.27 g/100 mL, respectively. Total phenolic flavonoid 2.42 mg GAE/mL 1.67 RE/mL, p-Hydroxybenzoic acid m-hydroxycinnamic the main polyphenols WFV. antioxidant 20.176 mM Trolox/L (ABTS), 8.614...
Wolfberry (Lycium barbarum L.), as a kind of functional fruit, has various nutritional and bioactive components, which exhibit healthy benefits. However, wolfberry is not easy to preserve, the intensive processing needs be developed. In present study, changes in phytochemical compounds, well antioxidant properties wolfberry, were evaluated brewed processes. We found that sugar contents significantly decreased, total acids values increased during fermentation The fat low fruit vinegar after...
The pectin methylesterases (PMEs) play multiple roles in regulating plant development and responses to various stresses. In our study, a total of 121 PME genes were identified the tobacco genome, which clustered into two groups based on phylogenetic analysis together with Arabidopsis members. investigations gene structure conserved motif indicated that exon/intron organizations relatively each group. Additionally, several stress-related elements promoter region these genes. survey...
The genetic diversity of 16 patchouli populations by random amplified polymorphic DNA (RAPD), morphology and chemical composition was presented in this paper. Polymorphism RAPD primers the percentage bands revealed with were 79.21 78.40%, respectively, which indicated a high level existed among Pogostemon cablin (Blanco) populations. A dendrogram based on analysis showed most from same or adjacent regions classified together. High polymorphism morphological parameters found among...
To analyze the clinical features of traumatic annular ciliochoroidal detachment (CCD) with ultrasound biomicroscopy (UBM) images, to investigate surgical outcomes ciliary body suturing and prognostic factors.Forty-two patients CCD who had undergone were enrolled for complete ocular examinations, including visual acuity (VA), slitlamp microscopy, tonometer, indirect ophthalscopy UBM. Comparisons performed among baseline follow-ups, morphologic alterations on UBM images analyzed between pre-...