A5102797547- Cancer therapeutics and mechanisms
- Plant biochemistry and biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Microbial Natural Products and Biosynthesis
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Cancer Mechanisms and Therapy
- Essential Oils and Antimicrobial Activity
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Connexins and lens biology
- Axial and Atropisomeric Chirality Synthesis
- MicroRNA in disease regulation
- Bryophyte Studies and Records
- Bioactive Natural Diterpenoids Research
- Neurological Disease Mechanisms and Treatments
- Viral Infections and Outbreaks Research
- Acute Lymphoblastic Leukemia research
- Traditional Chinese Medicine Analysis
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
First Affiliated Hospital of Henan University
2019-2025
Hebei Agricultural University
2024
Sun Yat-sen University
2024
Shandong University
2020-2021
Guizhou Normal University
2017
Xiamen University
2016
Kobe University
2008
Emory University
2003
Emory Eye Center
2003
Abstract The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays crucial role in execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify molecular chaperone Hsp90 as novel MLKL-interacting protein. We show associates with required for stability. Moreover, find also regulates stability upstream RIP3 kinase. Interference function 17AAG inhibitor...
Reportedly, long non-coding RNAs (lncRNAs) are implicated in hepatocellular carcinoma (HCC) progression, yet little is known concerning the biological functions of TTN antisense RNA 1 (TTN-AS1) HCC. In this study, quantitative real-time polymerase chain reaction (qRT-PCR) was performed for detecting TTN-AS1, SPOCK1 mRNA, and miR-139-5p expressions HCC cells tissues. After TTN-AS1 overexpressed or knocked down cells, CCK-8 5-Ethynyl-2ʹ-deoxyuridine (EdU) assays were carried out examining cell...
Actinomycin (Act) V, an analogue of Act D, presented stronger antitumor activity and less hepatorenal toxicity than D in our previous studies, which is worthy further investigation. We hereby report that V induces apoptosis via mitochondrial PI3K/AKT pathways colorectal cancer (CRC) cells. V-induced was characterized by dysfunction, with loss mitochondria membrane potential (MMP) cytochrome c release, then activated cleaved caspase-9, caspase-3, PARP, revealing it related to the pathway,...
The infection behavior of Japanese pear scab pathogen Venturia nashicola race 1 was studied ultrastructurally in acibenzolar-S-methyl (ASM)-pretreated susceptible (cv. Kousui) leaves to determine the mechanism ASM-induced resistance. On ASM-pretreated leaf surfaces, (conidial germination and appressorial formation) similar that on distilled water (DW)-pretreated prior cuticle penetration by pathogen. However, after penetration, differentiated found epidermal pectin layers middle lamellae...
Little is known about the interactions of bryophytes with their pathogens compared those flowering plants. This study used moss Physcomitrella patens and fungal pathogen Botrytis cinerea to investigate interaction at ultrastructural level. Infection behaviour B. in tissues was observed for 1–7 days after inoculation. Some appressoria directly penetrated P. cytoplasm through leaf cell walls, others entered intercellular spaces leaves infected cytoplasm. hyphae were sclerenchyma cells stems...
In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (Total_score) and C log P CPs are higher than that catalpol, which show the maybe served potential lead compounds new antiaging drugs. Furthermore, maximum Total_score isomers in one group is often not molecule with minimum energy structure. These GSH-Px only affected by energy, but also...
Abstract Catalpol has gained increasing attention for its potential contributions in controlling glycolipid metabolism and diabetic complications, which makes used as a very promising scaffold seeking new anti-diabetic drug candidates. Acylation derivatives of catalpol crotonate (CCs) were designed ligands glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surfex-Docking method. hexacrotonate (CC-6) was synthesized microwave assisted method characterized by FT-IR, NMR,...
A series of C10-position imidazole-modified catalpol derivatives are specifically designed and synthesized for serving as potential pancreatic cancer inhibitors, which characterized by 1 H NMR, 13 C NMR high-resolution mass spectrometry (HRMS). They were evaluated the 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) test on two human cells PANC-1, BxPC-3 normal cell HPDE6-C7, showed significant inhibitory effected growth PANC-1 BxPC-3, especially 91.6% efficacy 73.1%...
The high toxicity of actinomycin D (Act D) severely limits its use as a first-line chemotherapeutic agent in the clinic. Actinomycin V V), an analog Act D, exhibited strong anticancer activity our previous studies. Here, we provide evidence that has less hepatorenal than vitro and vivo, associated with reactive oxygen species (ROS) pathway. Compared to considerably stronger sensitivity for cancer cells human normal liver LO-2 embryonic kidney 293T using MTT...
Phytochemical investigation on the extract of endophytic fungus Tolypocladium sp. SHJJ1 resulted in identification a pair previously undescribed pyridoxatin atropisomers [1 (M/P)] and three new indole diterpenoids (3∼5), together with known [2 ten (6∼15). Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, quantum chemical calculations, X-ray diffraction. Among natural products, that two rapidly interconverting are third example to...
<title>Abstract</title> <bold>Background</bold> Plant salt tolerance is controlled by complex metabolic pathways. Gamma-aminobutyric acid (GABA) can act as a signaling molecule and metabolite to enhance plant tolerance. However, it not clear which pathway gene plays major role in the defense system under continuous influence of stress. The transcriptome data analysis 33 samples tomato (<italic>Solanum lycopersicum</italic> L.) seedling leaves 175 mmol·L<sup>−1</sup> stress for 0-96 h showed...
Abstract Catalpol hexapropionate (CP-6) was designed and synthesized as anti-aging drug. In order to investigate the behavior of CP-6 in simulated gastric juice, ultra-high performance liquid chromatography–electrospray ionization–high resolution mass spectrometry used determinate components produced conditions. Six metabolites were identified with possible metabolic processes proposed. Hydrolysis may be main pathways. The relative contents its determined using their extractive ion...
Wnt signaling has been implicated in the development and metastasis of colorectal cancer (CRC), as well poorer outcomes. Thus, targeting Wnt/β-catenin pathway is expected to be a promising treatment option for therapy advanced metastatic CRC. A new N-sulfonylamidine derivative (26ag) confirmed suppress growth tumor cells by inhibiting C-met, showing strong anti-cancer activity. In this paper, we test effectiveness 26ag suppressing CRC cell proliferation, invasion, migration. regard,...
Abstract Objective The objective of this study was to investigate potential mechanisms Yanghe Decoction ( , YHD) in treating soft tissue sarcoma (STS) and arteriosclerosis obliterans (ASO) based on the use network pharmacology. Methods Candidate compounds targets were identified through TCM Systems Pharmacology database a comprehensive literature search. Related STS ASO collected GeneCards database, DisGeNET Drugbank database. Furthermore, STRING 11.0 used determine protein–protein...
The conformational features of drugs are important with respect to their biological activity. In this report, we confirmed the solid-state conformation 1-(4′-azido-2′-deoxy-2′-fluoro-β-d-arabinofuranosyl) cytosine using single-crystal X-ray crystallography and conformations three 2′-deoxy-2′-fluoro-4′-substituted nucleosides in solution Altona-Haasnoot’s equations Nuclear Overhauser effect spectroscopy (NOESY). Furthermore, compared preferred these thermodynamics cycles obtain more evidence...