A5004016396- Pancreatic function and diabetes
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Diabetes Management and Research
- Vitamin K Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hormonal Regulation and Hypertension
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Nigella sativa pharmacological applications
- Infectious Diseases and Tuberculosis
- Cell death mechanisms and regulation
- Bacterial Identification and Susceptibility Testing
- Click Chemistry and Applications
- Cannabis and Cannabinoid Research
- Neuroendocrine Tumor Research Advances
- Neuroscience of respiration and sleep
- Virus-based gene therapy research
- Renal Transplantation Outcomes and Treatments
- Cardiovascular and Diving-Related Complications
- Bioactive Compounds and Antitumor Agents
- Immunotherapy and Immune Responses
- Renin-Angiotensin System Studies
- Lung Cancer Research Studies
University of Missouri
2022-2024
Center of Molecular Immunology (Cuba)
2023
Institute of Child Health
2023
University of Missouri Health System
2022-2023
Cell Biotech (South Korea)
2023
Biocat
2023
Erciyes University
2015
Leprosy is a chronic bacterial disease caused by Mycobacterium leprae . patients have been found to defects in T cells activation, which critical the clearance of bacilli. Treg cell suppression mediated inhibitory cytokines such as IL10, IL-35 and TGF-β its frequency higher leprosy patients. Activation overexpression programmed death 1 (PD-1) receptor considered one pathways inhibit T-cell response human leprosy. In current study we address effect PD-1 on Tregs function immuno-suppressive...
Thymoquinone (TQ) is the active ingredient of Nigella sativa which has a therapeutic potential in cancer therapy and prevention. In this study, TQ been shown to induce specific cytotoxicity apoptosis inhibit wound healing triple-negative breast cell line. also inhibited growth mouse tumor model. Moreover, paclitaxel (Pac) combination culture mice. Genes involved TQ-Pac-mediated were studied using focused real-time PCR arrays. After bioinformatic analysis, genes apoptosis, cytokine, p53...
Abstract Most pancreatic islets are destroyed immediately after intraportal transplantation by an instant blood-mediated inflammatory reaction (IBMIR) generated through activation of coagulation, complement, and proinflammatory pathways. Thus, effective mitigation IBMIR may be contingent on the combined use agents targeting these pathways for modulation. CD47 thrombomodulin (TM) two molecules with distinct functions in regulating coagulation responses. We previously reported that islet...
Purpose: Angiotensin converting enzyme inhibitors (ACEI) and type I angiotensin receptor blockers (ARB) have been shown to exert significant effects on bone tissue via a local renin-angiotensin-aldosterone system (RAS). The aim of our study was delineate their influences fracture healing process. Methods: Sixty adult male Wistar Albino rats were divided into three groups. After undergoing surgical femoral fixation, the ACEI group received 10 mg/kg Enalapril, ARB Losartan Control did not...
The instant blood-mediated inflammatory reaction (IBMIR) is initiated by innate immune responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin (TM) a multifaceted modulator. In this study, we report the generation of chimeric form thrombomodulin with streptavidin (SA-TM) for transient display on surface islets modified biotin to mitigate IBMIR. SA-TM protein expressed in insect cells showed expected structural and functional features. converted C into...
Alloreactive T-effector cells (Teffs) are the major culprit of acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation. Ex vivo nonspecific depletion T from donor graft impedes engraftment and posttransplant immune reconstitution. Teffs upregulate Fas after activation undergo ligand (FasL)-mediated restimulation-induced death (RICD), an important mechanism homeostasis. We targeted RICD as a means to eliminate host-reactive in for prevention aGVHD. A...
Murine intrahepatic islet transplantation is a clinically relevant but technically challenging surgical procedure because of frequent lethal postoperative bleeding. Here, we describe protocol for mouse pancreatic isolation, purification, and culture. Besides, also through the ileocolic vein. Intrahepatic vein, as opposed to traditional perfusion via main portal has advantage improving recovery after surgery may facilitate survival function in preclinical settings. For complete details on use...
This study was to determine the virulence encoding genes, and antibiotic resistance patterns of Staphylococcus aureus isolates, which were isolated from nasal samples chest clinic patients.The in-patients (431) out-patients (1857) in Kayseri Training Research Hospital's Chest Clinic, Kayseri, Turkey, cultured on CHROMagar (Biolife, Italiana) S. aureus, subcultured sheep blood agar for isolation aureus. Disc diffusion method used antimicrobial susceptibility testing. The occurrence...
Abstract The direct modulation of T cell responses is an emerging therapeutic strategy with the potential to modulate undesired immune including, autoimmune disease, and allogeneic cells transplantation. We have previously demonstrated that poly(lactide‐co‐glycolide) particles were able indirectly through antigen‐presenting (APCs). In this report, we investigated design nanoparticles can directly interact by coating membranes from APCs onto form membrane‐coated (MCNPs). Proteins within APCs,...
Propose: Instant blood-mediated inflammatory reaction (IBMIR) causes significant peri-transplant islet damage following intraportal transplantation. IBMIR is initiated and perpetuated by a cascade of cellular soluble innate immune responses, including high-mobility group box 1, tissue factor, macrophage chemoattractant protein-1, interleukin-1β. Thrombomodulin (TM) regulates coagulation suppresses functions neutrophils macrophages while CD47 inhibits phagocytosis macrophages, reducing...
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Abstract Acute GVHD initiated by donor T cells is a barrier to allogeneic bone marrow transplantation. Pan cell elimination from the graft associated with failure of stem engraftment and delayed immune reconstitution. upregulate Fas receptor on their surface following activation become susceptible FasL-mediated apoptosis. The objective this study was target Fas-mediated apoptosis for preferential alloreactive cells. We previously reported novel form FasL protein chimeric streptavidin...
Abstract Intraportal infusion of islets initiates an innate immune response termed instant blood-mediated inflammatory reaction (IBMIR) that is responsible for significant islet mass peritransplant. We herein used thrombomodulin (TM) as a multifaceted regulator to mitigate IBMIR prevent the destruction in minimal syngeneic intraportal transplantation model. A novel form TM molecule chimeric with streptavidin (SA-TM) was produced insect cells and characterized structure attachment...
Introduction: The instant blood mediated immune reaction (IBMIR) orchestrated by innate responses is responsible for substantial loss of islet mass following intraportal transplantation. Thrombomodulin (TM) a multifaceted modulator that blocks mediators coagulation, complement activation, and phagocytosis as major culprits IBMIR. In this study, we assessed the efficacy novel form TM in mitigating IBMIR minimal syngeneic transplantation model. Methods: A chimeric gene containing extracellular...